GHS Classification Result

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GENERAL INFORMATION

Item Information
CAS number 526-73-8
Chemical name 1,2,3-Trimethylbenzene
Substance ID 23A5029
Fiscal year of classification conducted FY2011
Classifier(s) (Ministries) Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
New/Revised New
Download in Excel format Excel file

REFERENCE INFORMATION

Item Information
Guidance used for classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition)
Definitions / Abbreviations (Excel file) Definitions / Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Explosives Not applicable - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - "Liquids" according to GHS definition.
3 Aerosols Not applicable - - - Not an aerosol product.
4 Oxidizing gases Not applicable - - - "Liquids" according to GHS definition.
5 Gases under pressure Not applicable - - - "Liquids" according to GHS definition.
6 Flammable liquids Category 3

Warning
H226
P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
A flash point of 44 degrees C [closed cup] (HSDB (2008)), which is >= 23 degrees C and <= 60 degrees C, corresponds to Category 3.
7 Flammable solids Not applicable - - - "Liquids" according to GHS definition.
8 Self-reactive substances and mixtures Not applicable - - - Containing neither chemical groups related to explosibility nor those related to self-reactivity.
9 Pyrophoric liquids Not classified - - - It is conceivable that it does not ignite at normal temperatures from an ignition temperature of 470 degrees C (Sax (11th, 2004)).
10 Pyrophoric solids Not applicable - - - "Liquids" according to GHS definition.
11 Self-heating substances and mixtures Classification not possible - - - No established test method suitable for liquid substances.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - An organic compound that does not contain oxygen, fluorine, or chlorine.
14 Oxidizing solids Not applicable - - - "Liquids" according to GHS definition.
15 Organic peroxides Not applicable - - - An organic compound that does not contain -O-O- structure.
16 Corrosive to metals Classification not possible - - - No data.

HEALTH HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - Lack of data.
Besides, a reported LDLo of 8900 mg/kg (RTECS (2009)) corresponds to "Not classified."
But the data are from List 3 with unknown details.
1 Acute toxicity (Dermal) Classification not possible - - - No data.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - "Liquids" according to GHS definition.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - No data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - No data.
2 Skin corrosion/irritation Classification not possible - - - No data.
Besides, there is information that liquid trimethylbenzene was a primary skin irritant (ACGIH (2001)).
3 Serious eye damage/eye irritation Classification not possible - - - No data.
4 Respiratory sensitization Classification not possible - - - No data.
4 Skin sensitization Classification not possible - - - No data.
5 Germ cell mutagenicity Classification not possible - - - The classification is not possible due to no in vivo test data.
Besides, a negative in an Ames test and a false negative in a chromosomal aberration test with CHL cells were reported as an in vitro tests (Report on Toxicity Tests of Chemical Substances, MHLW (2011)).
6 Carcinogenicity Classification not possible - - - No data.
7 Reproductive toxicity Classification not possible - - - No data.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation, Narcotic effects)

Warning
H335
H336
P304+P340
P403+P233
P261
P271
P312
P405
P501
From RD50 (concentrations depressing the respiratory rate to 50%) of 541 ppm for this substance in an inhalation exposure test in mice and description of a respiratory irritant (HSDB (2008)), it was classified in Category 3 (Respiratory tract irritation).
In addition, from an EC50 of 770 ppm for rotarod performance decrements (PATTY (5th, 2001)) and EC50 of 850 ppm for decrements in pain sensitivity (PATTY (5th, 2001)) in inhalation exposure to rats and the information that the acute toxicity of trimethylbenzene is due mainly to effects on the central nervous system (PATTY (5th, 2001)), it was classified in Category 3 (narcotic effects).
Besides, it is reported that neither irritation nor central nervous symptoms were observed in a test exposed 25 ppm to 10 subjects for 2 hours (PATTY (5th, 2001)).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - A 28-day repeated oral administration test in rats reported a decreased weight gain, changes in hematological and biochemical examinations such as prolonged prothrombin time and high total protein, increases in liver and kidney weights in a high dose group at 1000 mg/kg (converted to a 90-day equivalent value: 311 mg/kg/day), and hepatocyte swelling and hyaline droplets in the kidney as pathological signs at doses of 300 mg/kg (converted to a 90-day equivalent value: 93.3 mg/kg/day) or higher (Report on Toxicity Tests of Chemical Substances, MHLW (2011)). However, the changes in the liver were adaptive changes and the changes in kidney were nephropathy specific for male rats, therefore, it corresponds to "Not classified" in an oral route due to no serious adverse effects to human.
On the other hand, a 3-month repeated administration test by inhalation exposures to vapours in rats reported an increase in liver weight and changes in hematological parameters such as a decrease in red blood cells in a high dose group (1.23 mg/L) that was above a range of Guidance values, and an increased number of goblet cells and lesions in lung including interstitial lung parenchyma infiltration in both sexes in a high dose group (HSDB (2008)). However, the classification is not possible because effects around the upper limit in a range of Guidance values (1 mg/L) are unknown.
On the other hand, the classification is not possible in dermal administration due to no data.
From the above, it was classified as "classification not possible" in specific target organ toxicity (repeated exposures).
10 Aspiration hazard Classification not possible - - - No data.

ENVIRONMENTAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - No data.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - No data.
12 Hazardous to the ozone layer Classification not possible - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTES:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
   and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.



Updated date:
2016/10/13 Addition of Rationale for the classification

List of GHS Classification Results