GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 541-02-6 |
| Chemical name | 2,2,4,4,6,6,8,8,10,10-Decamethylcyclopentasiloxane |
| Substance ID | 23A5030 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Category 4 |
H227 |
P370+P378 P403+P235 P210 P280 P501 |
A flash point of 77 degrees C [closed cup] (Merck MSDS (2005)), which is > 60 degrees C and <= 93 degrees C, corresponds to Category 4. | |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition point of 450 degrees C (Merck MSDS (2005)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | It contains a semimetal (Si), but it is conceivable that it does not react vigorously with water from data on water solubility as 17 ppb (Merck (14th, 2008)) and 0.24 mg/L at 25 degrees C (Howard (1997)). |
| 13 | Oxidizing liquids | Classification not possible | - | - | - | An organic compound contains oxygen which is chemically bonded to Si, but the classification is not possible due to no data. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | On the basis of an LD50 value of > 24134 mg/kg for rats (RTECS (2009): the original literature, National Technical Information Service. OTS0572801), it was classified as "Not classified." |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - |
Lack of data. Besides, an LD50 value of > 16 mL/kg mg/kg (15.35 g/kg) for rats (RTECS (2009)) corresponds to "Not classified", but data were from List 3 and the details were unknown. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - |
Because the category cannot be determined from an LC50 value of > 178 ppm/4h (RTECS (2009)): the original literature, National Technical Information Service. OTS0572802), the classification is not possible. Besides, a reference value of gasses as a vapour with hardly included mist was applied because the test concentration (2.7 mg/L) is lower than 90 % of the saturated vapour pressure concentration (4 mg/L). |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - |
Lack of data. Besides, twenty-four-hour application of 500 mg to rabbit skins reported "mild" irritant (RTECS (2009)), but it was classified as "Classification not possible" due to data from List 3 and unknown details. |
| 3 | Serious eye damage/eye irritation | Not classified | - | - | - | On the basis of rate 1, which was observed after 24 hours, on a scale of 1 to 10 (least 1 to highest 10) according to the scale of injury (HSDB (2006)), it was classified as "Not classified." |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | No data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | No data. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - |
A test, in which rats were exposed for 70 days prior to mating, and males continued to be exposed throughout mating, and females continued to be exposed throughout mating and gestation and re-initiated on lactation day 5, reported that no adverse effects were observed in reproductive parameters related to mating, fertility, gestation, and parturition in the F0 and F1 generations, and no exposure-related changes were observed in birth, growth, and neurological behaviors in fetuses (HSDB (2006)). But, it was classified as "Classification not possible" due to no report on fetal examination at the end of gestation, and lack of data on developmental effects including teratogenicity. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | No data. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (lung) |  |
H373 |
P260 P314 P501 |
An rat inhalation test in exposures to vapours at 10 to 160 ppm for 4 weeks or at 26 to 224 ppm for 3 months reported alveolar macrophage accumulation accompanied by an increase in lung weights and interstitial inflammation at 4 weeks at a maximal concentration of 160 ppm (corresponds to 50 ppm = 0.745 mg/L for 90 days) as well as at 3 months at a maximal concentration of 224 ppm (3.40 mg/L), and histopathological evidence indicated the primary target organ following inhalation exposure was the lung (HSDB (2006)). Because the concentration that affected the lung in the 4-week inhalation test corresponds to a range of Category 2 in Guidance values, it was classified in Category 2 (lung). Besides, an increase in liver weights and changes in serum biochemical parameters (an increase in gamma-GT) were observed at the same dose, but they were not used as bases for classification due to lack of histopathological evidence in the liver. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | No data. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/8/17 Addition of Rationale for the classification |