GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 542-76-7 |
| Chemical name | beta-Chloropropiononitrile |
| Substance ID | 23A5032 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Category 4 |
|
H227 |
P370+P378 P403+P235 P210 P280 P501 |
A flash point of 76 degrees C [closed cup] (Sax (11th, 2004)), which is > 60 degrees C and <= 93 degrees C, corresponds to Category 4. |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Classification not possible | - | - | - | No data. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound that contains chlorine which is not chemically bonded to elements other than carbon. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |  |
H301 |
P301+P310 P264 P270 P321 P330 P405 P501 |
On the basis of an LD50 value of 100 mg/kg for rats (PATTY (5th, 2001)), it was classified in Category 3. Besides, there is an LD50 value of 9 mg/kg for mice (PATTY (5th, 2001)). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - |
Lack of data. Besides, PATTY reports that exposure to the vapor of 0.01 mL in a 1-L beaker killed all mice in 18 hours. (PATTY (5th, 2001)) |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | No data. |
| 3 | Serious eye damage/eye irritation | Category 2B |
|
H320 |
P305+P351+P338 P337+P313 P264 |
All of redness and chemosis in conjunctiva observed 1 hour after application and corneal opacity observed 1 day after application in a test in which instillation of 0.1 mL of an undiluted test substance was dosed into eyes of 3 rabbits (OECD TG405, GLP) disappeared in 3 days. It was classified in Category 2B because 2 out of 3 animals had an average score (a calculated value) of 1 in corneal opacity after 24, 48 and 72 hours although MMAS (corresponding to AOI) was 13.7 which is not higher than 15 (ECETOC TR48 (1998)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | No data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, an Ames test in an in vitro test reported a positive result (NTP DB (2000)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system) |  |
H370 |
P307+P311 P260 P264 P270 P321 P405 P501 |
Because doses of LD50 values which are 100 mg/kg for rats and 9 mg/kg for mice on the basis that symptoms are those of deep anesthesia with no demonstrable pathology after oral administration to rats or mice correspond to Category 1 in guidance values, it was classified in Category 1 (central nervous system). Besides, HSDB says, "it can be metabolized to cyanide." (HSDB (2003)) There is information that the main effects of acute cyanide exposure are central nervous system and cardiovascular system, and symptoms are tachypnea, headache, vertigo, weak pulse, cardiac arrhythmia, vomiting, stupor, convulsions, and coma (ATSDR (2006), CICADs 61 (2004)). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - |
No data. Besides, HSDB says, "it can be metabolized to cyanide." (HSDB (2003)) and chronic exposure to cyanide in occupational setting causes a variety of symptoms affecting the central nervous system such as fatigue, dizziness, headaches, paresthesias of extremities, syncopes, hemiparesis, hemianopia, decreases in visual acuity, and psychomotor ability (ATSDR (2006), CICADs 61 (2004)). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | No data. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/8/17 Addition of Rationale for the classification |