GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 760-67-8 |
| Chemical name | 2-Ethylhexanoyl chloride |
| Substance ID | 23A5035 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Category 4 |
H227 |
P370+P378 P403+P235 P210 P280 P501 |
A flash point of 69 degrees C [closed-cup] (Lange (16th, 2005)) is > 60 degrees C and <= 93 degrees C, therefore, it corresponds to Category 4. | |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | Containing neither chemical groups related to explosibility nor those related to self-reactivity. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition point of 225 degrees C (Hommel (1996)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound that contains oxygen and chlorine which are not chemically bonded to elements other than carbon. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |  |
H302 |
P301+P312 P264 P270 P330 P501 |
On the basis of an LD50 value of 1410 mg/kg for rats (US EPA guidelines, GLP compliance) (IUCLID (2000)), it was classified in Category 4. |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | On the basis of an LD50 value of >2010 mg/kg for rabbits (US EPA guidelines, GLP compliance) (IUCLID (2000)), it was classified as "Not classified" in JIS classification (corresponding to Category 5 or "Not classified" in UN GHS classification). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 2 |  |
H330 |
P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
On the basis of LD50 values of 1.583 to 3.583 mg/L/4h for rats (238 to 539 ppm/4h) (OECD TG403, GLP compliance) (IUCLID (2000)), it was classified in Category 2. Besides, a reference value of gasses as vapour with hardly included mist was applied because the test concentrations (238 to 539 ppm) are lower than 90 % of the saturated vapour pressure concentration (2468 ppm). |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Category 2 | |
H330 |
P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
On the basis of LD50 values of 1.26 mg/L/1h (0.32 mg/L/4h) (GLP compliance) and <2.3 mg/L/1h (<0.575 mg/L/4h) for rats (both IUCLID (2000)), it was classified in Category 2. Besides, a reference value of mists was applied because there is information that both tests were conducted on aerosols (IUCLID (2000)). |
| 2 | Skin corrosion/irritation | Category 1 |  |
H314 |
P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
It was classified in Category 1 from a result as "corrosive" in a test using rabbits (OECD TG404, GLP compliance) (IUCLID (2000)). Besides, another rabbit test reports that necrosis was observed 72 hours and 7 days after application (Directive 84/449/EEC B.4, GLP compliance) (IUCLID (2000)). |
| 3 | Serious eye damage/eye irritation | Category 2A | |
H319 |
P305+P351+P338 P337+P313 P264 P280 |
Two tests using rabbits (OECD TG405, GLP compliance and Directive 84/449/EEC B.5, GLP compliance) both result in "irritating" (IUCLID (2000)), and eye irritation properties of this substance is described as "moderate to severely irritating to the eye" (SIAP (2008)), therefore it was classified in Category 2A. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | No data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, an Ames test reports a negative result in an in vitro test (OECD TG471) (IUCLID (2000)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
| 8 | Specific target organ toxicity - Single exposure | Category 2 (respiratory system) |  |
H371 |
P309+P311 P260 P264 P270 P405 P501 |
An inhalation exposure test to rats reports that all animals died within 3.5 hours of exposure at a dose of 2.3 mg/L and severe irritant to a respiratory tract was observed in pathological findings (IUCLID (2000)). The above dose corresponds to Category 1 or Category2 from total mortality, but it was classified in Category 2 (respiratory system) in accordance with Guidance because the data are from List 2 and do not meet decision criteria 1b3) (OECD TG and GLP). Besides, a reference value of mists was applied because there is information that the above test was conducted on aerosols (IUCLID (2000)). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | No data. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | No data. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/7/13 Addition of Rationale for the classification |