GHS Classification Result

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GENERAL INFORMATION

Item Information
CAS number 1569-01-3
Chemical name 1-Propoxy-2-propanol
Substance ID 23A5039
Fiscal year of classification conducted FY2011
Classifier(s) (Ministries) Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
New/Revised New
Download in Excel format Excel file

REFERENCE INFORMATION

Item Information
Guidance used for classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition)
Definitions / Abbreviations (Excel file) Definitions / Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Explosives Not applicable - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - "Liquids" according to GHS definition.
3 Aerosols Not applicable - - - Not an aerosol product.
4 Oxidizing gases Not applicable - - - "Liquids" according to GHS definition.
5 Gases under pressure Not applicable - - - "Liquids" according to GHS definition.
6 Flammable liquids Category 3

Warning
H226
P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
A flash point of 48 degrees C [closed cup] (GESTIS (Access on May. 2011)), which is >= 23 degrees C and <= 60 degrees C, corresponds to Category 3.
7 Flammable solids Not applicable - - - "Liquids" according to GHS definition.
8 Self-reactive substances and mixtures Not applicable - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - It is conceivable that it does not ignite at normal temperatures from an auto-ignition temperature of 252 degrees C (MSDS (Sigma-Aldrich) (Access on May. 2011)).
10 Pyrophoric solids Not applicable - - - "Liquids" according to GHS definition.
11 Self-heating substances and mixtures Classification not possible - - - No established test method suitable for liquid substances.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - An organic compound contains oxygen which is not chemically bonded to elements other than carbon or hydrogen.
14 Oxidizing solids Not applicable - - - "Liquids" according to GHS definition.
15 Organic peroxides Not applicable - - - An organic compound that does not contain -O-O- structure.
16 Corrosive to metals Classification not possible - - - No data.

HEALTH HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - On the basis of 4 LD50 values for rats (4370 mg/kg, 2510 mg/kg, 2890 mg/kg and 2800-3000 mg/kg) (all PATTY (5th, 2001)), it was classified as "Not classified" in JIS classification (Category 5 in UN GHS classification).
1 Acute toxicity (Dermal) Not classified - - - On the basis of 4 LD50 values for rabbits (3550 mg/kg, 3810 mg/kg, 2820 mg/kg, 4370 mg/kg) (all PATTY (5th, 2001)), it was classified as "Not classified" in JIS classification (Category 5 in UN GHS classification).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - "Liquids" according to GHS definition.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - No mortality in rats both in an 8-hour exposure to saturated vapour pressure concentration (11.7 mg/L) (converted to a 4-hour exposure equivalent value: 16.5 mg/L) and in 6-hour exposure to saturated vapour pressure concentration (10.8 mg/L) (converted to a 4-hour exposure equivalent value: 13.2 mg/L) were reported. (PATTY (5th, 2001)
Because the category cannot be determined from the reports, it was classified as "Classification not possible."
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - No data.
2 Skin corrosion/irritation Category 2

Warning
H315
P302+P352
P332+P313
P264
P280
P321
P362
On the basis that occlusive applications of 0.5 mL for 4 hours to rabbit skins produced mild to moderate erythema and edema in 4 out of 6 animals, but no necrosis or ulceration (PATTY (5th, 2001)), it was classified in Category 2.
Besides, another test of an occlusive application to rabbits for 24 hours reports slightly irritant (ECETOC TR 95 (2005)), and another reports that severe irritation with persistent fissuring, desquamation, ulceration, and necrosis appeared under more rigorous conditions (PATTY (5th, 2001)).
3 Serious eye damage/eye irritation Category 2A

Warning
H319
P305+P351+P338
P337+P313
P264
P280
Because a reversing time is over 7-day in a test which reported that instillation of 0.005 to 0.1 mL into rabbit eyes caused severe conjunctivitis and a mild diffuse corneal injury which required 3 to 14 days for complete recovery (PATTY (5th, 2001)), it was classified in Category 2A.
Besides, another test using rabbits reported that a moderate to severe irritation, a moderate corneal injury, and slight iritis observed reversed within a week (HSDB (2002)).
4 Respiratory sensitization Classification not possible - - - No data.
4 Skin sensitization Classification not possible - - - No data.
5 Germ cell mutagenicity Classification not possible - - - The classification is not possible due to no in vivo test data.
Besides, negatives in an Ames test and a chromosomal aberration test using rat lymphocyte are reported as in vitro tests (ECETOC TR 95 (2005)).
6 Carcinogenicity Classification not possible - - - No data.
7 Reproductive toxicity Classification not possible - - - In an inhalation test exposed to pregnant rats during an organogenetic period, only observed symptoms of periocular encrustation, microscopic evidence of a corneal ulcer in maternal animals, and poor ossification of proximal phalanges of the hind limb in fetuses, but no maternal or fetal toxicity were reported. (ECETOC TR 95 (2005))
In an inhalation test exposed to pregnant rabbits during an organogenetic period, symptoms of hypoactivity, ataxia, prostration, and emaciation, and a high degree of mortality (27.3%) in a high dose group, but no effects on pregnancy and fetal parameters were observed. (ECETOC TR 95 (2005))
However, it was classified as "Classification not possible" due to lack of data, because there are no data on adverse effects on sexual function and fertility caused by exposures prior to mating.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects)

Warning
H336
P304+P340
P403+P233
P261
P271
P312
P405
P501
On the basis that anesthetization without mortality in an 8-hour inhalation exposure to rats, CNS depression by oral administration of high dose to rats, and comatose within 15 to 30 minutes of dermal application to rabbits were observed (all PATTY (5th, 2001)), it was classified in Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - In an inhalation test exposed to two strains of rats (SD and Fisher 344) for 6 hours a day for 14 weeks, the female Fischer 344 rats showed decreased weight gains in a high concentration group (300 ppm), but both strains showed no difference from a control group in weights, food and water consumption, no abnormalities in necropsy, and no exposure-related changes in a pathological test. (ECETOC TR 95 (2005)).
Three hundred ppm (1.475 mg/L) in the high concentration group, which is above the upper limit in Guidance value (1 mg/L), corresponds to "Not classified" in inhalation exposure, however, effects in other administration routes (oral, dermal) are unknown due to no data.
Therefore, it was classified as "Classification not possible" in specific target organ toxicity (repeated exposures).
10 Aspiration hazard Classification not possible - - - No data.

ENVIRONMENTAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - No data.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - No data.
12 Hazardous to the ozone layer Classification not possible - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTES:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
   and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.



Updated date:
2016/8/17 Addition of Rationale for the classification

List of GHS Classification Results