Item | Information |
---|---|
CAS number | 13547-70-1 |
Chemical name | 1-Chloro-3,3-dimethyl-2-butanone |
Substance ID | 23A5042 |
Fiscal year of classification conducted | FY2011 |
Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
New/Revised | New |
Download in Excel format | Excel file |
Item | Information |
---|---|
Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition) |
Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | "Liquids" according to GHS definition. |
3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
6 | Flammable liquids | Category 4 |
|
H227 |
P370+P378 P403+P235 P210 P280 P501 |
A flash point of 67 degrees C [closed cup] (MSDS (Sigma-Aldrich) (2011)), which is > 60 degrees C and <= 93 degrees C, corresponds to Category 4. |
7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition point of 516 degrees C (IUCLID (2000). |
10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | It contains oxygen and chlorine which are not chemically bonded to elements other than carbon. |
14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
H301 |
P301+P310 P264 P270 P321 P330 P405 P501 |
On the basis of an LD50 value of 250 mg/kg for rats (IUCLID (2000)), it was classified in Category 3. | |
1 | Acute toxicity (Dermal) | Category 3 |
H311 |
P302+P352 P280 P312 P322 P361 P363 P405 P501 |
On the basis of an LD50 value of 270 mg/kg for rats (IUCLID (2000)), it was classified in Category 3. | |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | "Liquids" according to GHS definition. |
1 | Acute toxicity (Inhalation: Vapours) | Category 2 |
H330 |
P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
On the basis of an LC50 value for rats: 138 ppm in a 4-hour exposure (OECD TG 403; GLP) (IUCLID (2000)), it was classified in Category 2. Besides, a reference value of gasses as a vapour with hardly included mist was applied because the LC50 value (138 ppm) is lower than 90 % of the saturated vapour pressure concentration (3868 ppm). |
|
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | No data. |
2 | Skin corrosion/irritation | Category 2 |
H315 |
P302+P352 P332+P313 P264 P280 P321 P362 |
On the basis of a "highly irritating" result in an occlusive test applied to rabbit skins for 4 hours (US-EPA-TSCA Health Effects Testing Guidelines and US-EPA-FIFRA, Pesticide Assessment Guidelines; GLP compliance) (IUCLID (2000)), it was classified in Category 2. Besides, details of a test which reported that an occlusive application to rabbit auricular skins for 1 to 8 hours resulted in corrosive (IUCLID (2000)) are unknown. |
|
3 | Serious eye damage/eye irritation | Category 2 |
H319 |
P305+P351+P338 P337+P313 P264 P280 |
On the basis that a test using rabbit reported highly irritating (IUCLID (2000)), it was classified in Category 2. | |
4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
4 | Skin sensitization | Classification not possible | - | - | - | No data. |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | No data. |
6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | No data. |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory tract) |
H372 |
P260 P264 P270 P314 P501 |
In a 4-week inhalation (vapour) exposure test in rats (OEDD TG 412; GLP), the test substance caused respiratory tract irritation symptoms at a concentration of 0.1083 mg/L/6h (converted to a 90-day equivalent value: 0.033 mg/L/6h) such as bradypnea, labored breathing, rale, cyanosis, serous nasal discharge. And pathological signs such as inflammatory changes with a wide area of metaplasia of flat epithelium accompanied by partial cornification complicated by the invasion of round cells in the nasal cavity, paranasal cavity, oropharynx, nasopharynx, pharynx and respiratory tract, and atrophy of olfactory epithelium were reported. And the number of animals with slightly significant subpleural round cell invasion increased slightly. (IUCLID (2000)) Due to the main effects on a nose, oropharynx, pharynx and respiratory tract, and no serious effects on the lung, and the exposure concentration corresponding to Category 1 of a range of Guidance values, it was classified in Category 1 (respiratory tract). |
|
10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible | - | - | - | No data. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible | - | - | - | No data. |
12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
2016/9/2 Addition of Rationale for the classification |