GHS Classification Result

日本語で表示

GENERAL INFORMATION

Item Information
CAS number 14667-55-1
Chemical name 2,3,5-Trimethylpyrazine
Substance ID 23A5055
Fiscal year of classification conducted FY2011
Classifier(s) (Ministries) Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
New/Revised New
Download in Excel format Excel file

REFERENCE INFORMATION

Item Information
Guidance used for classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition）
Definitions / Abbreviations (Excel file) Definitions / Abbreviations
Model Label by MHLW (External link) MHLW Website （in Japanese Only）
Model SDS by MHLW (External link) MHLW Website （in Japanese Only）
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS

Hazard class Classification Symbol
Signal word 		Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - "Liquids" according to GHS definition.
3 Aerosols Not applicable - - - Not an aerosol product.
4 Oxidizing gases Not applicable - - - "Liquids" according to GHS definition.
5 Gases under pressure Not applicable - - - "Liquids" according to GHS definition.
6 Flammable liquids Category 3

Warning
 H226
 P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
 A flash point of 54 degrees C [closed cup] ((MSDS Sigma-Aldrich) (2011)) is >= 23 degrees C and <= 60 degrees C, therefore it corresponds to Category 3.
7 Flammable solids Not applicable - - - "Liquids" according to GHS definition.
8 Self-reactive substances and mixtures Not applicable - - - Containing neither chemical groups related to explosibility nor those related to self-reactivity.
9 Pyrophoric liquids Classification not possible - - - No data.
10 Pyrophoric solids Not applicable - - - "Liquids" according to GHS definition.
11 Self-heating substances and mixtures Classification not possible - - - No data.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - An organic compound that does not contain oxygen, fluorine, or chlorine.
14 Oxidizing solids Not applicable - - - "Liquids" according to GHS definition.
15 Organic peroxides Not applicable - - - An organic compound that does not contain -O-O- structure.
16 Corrosive to metals Classification not possible - - - No data.

HEALTH HAZARDS

Hazard class Classification Symbol
Signal word 		Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4

Warning
 H302
 P301+P312
P264
P270
P330
P501
 On the basis of an LD50 value of 810 mg/kg for rats (JECFA 1032 (2002)), it was classified in Category 4.
1 Acute toxicity （Dermal） Classification not possible - - - No data.
1 Acute toxicity （Inhalation: Gases） Classification not possible - - - No data.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - No data.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - No data.
2 Skin corrosion/irritation Classification not possible - - - No data.
3 Serious eye damage/eye irritation Classification not possible - - - No data.
4 Respiratory sensitization Classification not possible - - - No data.
4 Skin sensitization Classification not possible - - - No data.
5 Germ cell mutagenicity Classification not possible - - - The classification is not possible due to no in vivo test data.
Besides, a negative in an Ames test (JECFA No. 1032 (2002)) and a negative in a chromosome aberration test (Evaluation of effect for the food safety (2005)) as in vitro tests were reported.
6 Carcinogenicity Classification not possible - - - No data.
7 Reproductive toxicity Classification not possible - - - No data.
8 Specific target organ toxicity - Single exposure Classification not possible - - - No data.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - A 90-day diet administration test given only one dose (corresponding to 18 mg/kg bw/day) to rats reports that slight to moderate decreases in body-weight gain in females (not statistically significant) were observed but no other differences were found between test and control groups, and NOELs were 17 mg/kg/day in males and 18 mg/kg/day in females (JECFA 1032 (2002)).
But this dose is in a range of Guidance values, and effects at a high dose are unknown due to no data, therefore it was classified as "Classification not possible" due to lack of data.
10 Aspiration hazard Classification not possible - - - No data.

ENVIRONMENTAL HAZARDS

Hazard class Classification Symbol
Signal word 		Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - No data.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - No data.
12 Hazardous to the ozone layer Classification not possible - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTES:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.



Updated date:
2016/6/29 Addition of Rationale for the classification

List of GHS Classification Results