GHS Classification Result

日本語で表示

GENERAL INFORMATION

Item Information
CAS number 2402-79-1
Chemical name 2,3,5,6-Tetrachloropyridine
Substance ID 23A5058
Fiscal year of classification conducted FY2011
Classifier(s) (Ministries) Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
New/Revised New
Download in Excel format Excel file

REFERENCE INFORMATION

Item Information
Guidance used for classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition)
Definitions / Abbreviations (Excel file) Definitions / Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Explosives Not applicable - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - "Solids" according to GHS definition.
3 Aerosols Not applicable - - - Not an aerosol product.
4 Oxidizing gases Not applicable - - - "Solids" according to GHS definition.
5 Gases under pressure Not applicable - - - "Solids" according to GHS definition.
6 Flammable liquids Not applicable - - - "Solids" according to GHS definition.
7 Flammable solids Classification not possible - - - No data.
8 Self-reactive substances and mixtures Not applicable - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - "Solids" according to GHS definition.
10 Pyrophoric solids Classification not possible - - - No data.
11 Self-heating substances and mixtures Classification not possible - - - No established test method suitable for solid substances with a melting point of 140 degrees C or lower.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - "Solids" according to GHS definition.
14 Oxidizing solids Not applicable - - - An organic compound contains chlorine which is not chemically bonded to elements other than carbon.
15 Organic peroxides Not applicable - - - An organic compound that does not contain -O-O- structure.
16 Corrosive to metals Classification not possible - - - No established test method suitable for solid substances.

HEALTH HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Acute toxicity (Oral) Category 4

Warning
H302
P301+P312
P264
P270
P330
P501
On the basis of LD50 values of 1414 mg/kg (males) and 1182 mg/kg (females) for rats (EPA Health Effects Test Guidelines (1982); GLP) (SIDS (Access on May 2011)), it was classified in Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - No data.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - "Solids" according to GHS definition.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - No data.
1 Acute toxicity (Inhalation: Dusts and mists) Not classified - - - On the basis of an LC0 value of 98 mg/L/4h for rats (US EPA/HPV (2005), corresponding to List 1), it was classified as "Not classified."
Besides, it was considered to be a test by dust because the test concentration (56 mg/L) is above the saturated vapour pressure concentration (0.234 mg/L).
2 Skin corrosion/irritation Not classified - - - Only a very slight effect (slight hyperemia), which was observed by 3 to 10 times applications of an undiluted test substance to rabbit belly skin for 14 days, disappeared in a few days. It was assessed as not irritating. (US EPA/HPV (2005))
On the basis of the result of the assessment, it was classified as "Not classified."
3 Serious eye damage/eye irritation Not classified - - - On the basis that a very slight prominence of conjunctival capillaries, which was observed after application of an undiluted test substance to eyes of one rabbit, almost disappeared within one hour and was assessed as not irritating (US EPA/HPV (2005)), it was classified as "Not classified."
4 Respiratory sensitization Classification not possible - - - No data.
4 Skin sensitization Classification not possible - - - Because a skin sensitization test using guinea pigs (Maguire method), which concluded that this substance did not cause a delayed contact hypersensitivity in guinea pigs, all of which did not show skin reactions after a challenge (positive rate 0% (0/10)) (US EPA/HPV (2005)), was not a test method approved by OECD, it was classified as "Classification not possible."
5 Germ cell mutagenicity Not classified - - - On the basis of a negative result in a micronucleus test using bone marrow cells after an oral administration to mice (in vivo somatic cell mutagenicity test) (US EPA/HPV (2005)), it was classified as "Not classified."
Besides, a negative in an Ames test is reported as an in vitro test (US EPA/HPV (2005)).
6 Carcinogenicity Classification not possible - - - No data.
7 Reproductive toxicity Classification not possible - - - A reproduction/ developmental toxicity screening test in rats found increased liver weights and centrilobular hypertrophy of hepatocytes in parent animals as general toxicities, but no adverse effects on sexual function and fertility including mating, gestation and fertility and no adverse effects on a fetal development such as litter size, neonatal growth or survival (US EPA/HPV (2005)).
However, it was classified as "Classification not possible" because data on fetal developmental toxicity including teratogenicity were insufficient due to no fetal data at the end of a gestation period.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects)

Warning
H336
P304+P340
P403+P233
P261
P271
P312
P405
P501
On the basis that some animals of all dose group showed lethargy, loss of coordination, and palpebral closure in oral administration of 500 to 2000 mg/kg to rats (LD50 value: 1182 to 1414 mg/kg) and all survivors appeared normal within four days after administration (US EPA/HPV (2005)), it was classified in Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - In a 91-day diet administration test in rats, increased weights of kidney, liver, and spleen were found, and mild degeneration (hyaline droplet) in the kidney in males at doses of 10 to 100 mg/kg/day was observed as the only histopathological change.
However, a NOAEL was reported to be 100 mg/kg/day in this test, because these changes in the kidney, which were specific to male rats, had no toxicological significance to humans, and increased weights in organs, which were not accompanied by histopathological changes, were considered to be no toxicological significance (US EPA/HPV (2005)).
Accordingly, it corresponds to "Not classified" in an oral route, but it was classified as "Classification not possible" in specific target organ toxicity (repeated exposures) because effects in other routes are unknown due to no data.
10 Aspiration hazard Classification not possible - - - No data.

ENVIRONMENTAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - H401
P273
P501
From 96-hour LC50 = 1.5 mg/L for fish (Oncorhynchus mykiss) (SIDS, 2002), it was classified in Category 2.
11 Hazardous to the aquatic environment (Long-term) Category 2
H411
P273
P391
P501
If chronic toxicity data are used, then it is classified in Category 2 due to non-rapidly degradable (BIOWIN) and 21-day NOEC = 0.31mg/L for crustacea (Daphnia magna) (SIDS, 2002).
If acute toxicity data are used for a trophic level for which chronic toxicity data are lacking, then it is classified in Category 2 due to non-rapidly degradable (BIOWIN) and 96-hour LC50 = 1.5 mg/L for fish (Oncorhynchus mykiss) (SIDS, 2002).
From the above results, it was classified in Category 2.
12 Hazardous to the ozone layer Classification not possible - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTES:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
   and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.



Updated date:
2016/10/13 Addition of Rationale for the classification

List of GHS Classification Results