GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 6485-40-1 |
| Chemical name | L-Carvone |
| Substance ID | 23A5068 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | It is a liquid at normal temperatures (Merck (14th, 2006)). |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | It is a liquid at normal temperatures (Merck (14th, 2006)). |
| 5 | Gases under pressure | Not applicable | - | - | - | It is a liquid at normal temperatures (Merck (14th, 2006)). |
| 6 | Flammable liquids | Category 4 |
H227 |
P370+P378 P403+P235 P210 P280 P501 |
It was classified in Category 4 because it is estimated to be > 60 degrees C and <= 93 degrees C in a prescribed test from data as 88 degrees C (Lange (16th, 2005)) and 92 degrees C (GESTIS (Access on June. 2011)) in unknown test methods. | |
| 7 | Flammable solids | Not applicable | - | - | - | It is a liquid at normal temperatures (Merck (14th, 2006)). |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | There is a chemical group present in the molecule associated with a self-reactive property (unsaturated bond), but the classification is not possible due to no data. |
| 9 | Pyrophoric liquids | Classification not possible | - | - | - | No data. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | It is a liquid at normal temperatures (Merck (14th, 2006)). |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound that does not contain fluorine or chlorine but contains oxygen which is not chemically bonded to elements other than carbon. |
| 14 | Oxidizing solids | Not applicable | - | - | - | It is a liquid at normal temperatures (Merck (14th, 2006)). |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |  |
H302 |
P301+P312 P264 P270 P330 P501 |
On the basis of an LD50 value of 1640 mg/kg for rats (JECFA 718 (1991)), it was classified in Category 4. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | It is a liquid at normal temperatures (Merck (14th, 2006)). |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - |
Lack of data. Besides, a 48-hour closed patch test in which humans were exposed to concentrations of 1 % (-)-carvone in petrolatum reports that no irritation was observed (JECFA 718 (1991)). |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | No data. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - |
It is reported that users of toothpaste and chewing gum containing this substance often showed contact allergy, and 15 out of 541 patients showed a positive reaction to this substance and a positive reaction was doubted in 12 patients (HSDB (2002)), and three out of 33 patients tested for contact allergy to toothpaste experienced a positive allergic response in a patch-test using carvone (JECFA 718 (1991)). On the other hand, it is reported that a maximization test to this substance carried out on 25 volunteers produced no sensitization reactions. Therefore, it was classified as "Classification not possible" due to insufficient data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, in vitro test results as "negative" in an Ames test and "equivocal" in a chromosomal aberration test using Chinese hamster ovary cells are reported (JECFA 944 (1999)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - |
Lack of data. Besides, a carcinogenicity test in which mice were given d-carvone for 2 years reports that no increases in tumor incidences were observed in mice administered d-carvone (NTP TR 381 (1990)). |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | No data. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - |
Lack of data. Besides, some reports serum cholesterol and triacylglycerol increases in oral administration of 500 mg/kg/day to rats for 14 days (converted to a 90-day equivalent: 78 mg/kg/day) (JECFA 718 (1991)), growth depression and testicular atrophy in diet administration of 1.0 % (500 mg/kg/day) for 16 weeks (JECFA 718 (1991)), and no adverse effects in diet administration of 0.25 % (125 mg/kg) for 1 year (JECFA 718 (1991)), but it was classified as "Classification not possible" because L-body or D-body is unknown about the test substance and details of results are unknown. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | No data. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/7/13 Addition of Rationale for the classification |