GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 106-75-2 |
| Chemical name | 2,2'-Oxydiethyl bis(chloroformate) |
| Substance ID | 23A5077 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Not classified | - | - | - | A flash point of 126 degrees C [closed cup] (BUA 82 (1991)) is above 93 degrees C. |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | Containing neither chemical groups related to explosibility nor those related to self-reactivity. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition point of 370 degrees C (IUCLID (2000)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound that contains oxygen and chlorine which are not chemically bonded to elements other than carbon. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |  |
H302 |
P301+P312 P264 P270 P330 P501 |
Both of two LD50 values for rats (389 mg/kg and 1650 mg/kg) (IUCLID (2000)) correspond to Category 4. |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | On the basis of an LD50 value of > 2000 mg/kg for rabbits (SIAP (2000)), it was classified as "Not classified" in JIS classification (equivalent to Category 5 in UN GHS classification or "Not classified"). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Category 2 |  |
H330 |
P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
On the basis of an LC50 value of 1.62 mg/kg/1h = 0.405 mg/L/4h for mice (IUCLID (2000)), it was classified in Category 2. Besides, it was considered to be a test by mist because the LC50 value (1.62 mg/L) was higher than the saturated vapour pressure concentration (0.0166 mg/L). |
| 2 | Skin corrosion/irritation | Category 2 | |
H315 |
P302+P352 P332+P313 P264 P280 P321 P362 |
On the basis of results as "moderately to severely irritating" in a test using rabbits (SIAP (2010)) and as "irritating" in another test using rabbits (IUCLID (2000)), it was classified in Category 2. Besides, it is classified in Xi; R38 in EU classification. |
| 3 | Serious eye damage/eye irritation | Category 1 |  |
H318 |
P305+P351+P338 P280 P310 |
A test using rabbits reports that irritation is as strong as recovery cannot be expected (IUCLID (2000)), and there is information that almost all chloroformates including this substance caused irreversible damage to the eye in animal tests (SIAP (2010)). Therefore, it was classified in Category 1. Besides, it is classified in Xi; R41 in EU classification (EC-JRC (ESIS) (Access on June 2011)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | No data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, an Ames test as an in vitro test reports a negative (IUCLID (2000)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - |
No data. Besides, information that acute toxic effects of the chloroformates are primarily local caustic/irritating effects at the site of contact, clinical findings include bloody/nasal discharge, dyspnea, gasping, and irregular respiration, and hyperaemic, oedematous, red/haemorrhagic lungs were found at necropsy for multiple chloroformates is not definite about this substance. It was classified as "Classification not possible" due to lack of data. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | No data. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | No data. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/7/13 Addition of Rationale for the classification |