GHS Classification Result

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GENERAL INFORMATION

Item Information
CAS number 112-56-1
Chemical name 2-Butoxyethyl 2-thiocyanoethyl ether
Substance ID 23A5081
Fiscal year of classification conducted FY2011
Classifier(s) (Ministries) Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
New/Revised New
Download in Excel format Excel file

REFERENCE INFORMATION

Item Information
Guidance used for classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition)
Definitions / Abbreviations (Excel file) Definitions / Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Explosives Not applicable - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - It is a liquid at normal temperatures. (CRC (91st, 2010))
3 Aerosols Not applicable - - - Not an aerosol product.
4 Oxidizing gases Not applicable - - - It is a liquid at normal temperatures. (CRC (91st, 2010))
5 Gases under pressure Not applicable - - - It is a liquid at normal temperatures. (CRC (91st, 2010))
6 Flammable liquids Category 3

Warning
H226
P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
A flash point of 51.67 degrees C (125 degrees F) [closed cup] (HSDB (2002)), which is >= 23 degrees C and <= 60 degrees C, corresponds to Category 3.
7 Flammable solids Not applicable - - - It is a liquid at normal temperatures. (CRC (91st, 2010))
8 Self-reactive substances and mixtures Not applicable - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible - - - No data.
10 Pyrophoric solids Not applicable - - - It is a liquid at normal temperatures. (CRC (91st, 2010))
11 Self-heating substances and mixtures Classification not possible - - - No established test method suitable for liquid substances.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - An organic compound contains oxygen which is not chemically bonded to elements other than carbon or hydrogen.
14 Oxidizing solids Not applicable - - - It is a liquid at normal temperatures. (CRC (91st, 2010))
15 Organic peroxides Not applicable - - - An organic compound that does not contain -O-O- structure.
16 Corrosive to metals Classification not possible - - - No data.

HEALTH HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Acute toxicity (Oral) Category 3

Danger
H301
P301+P310
P264
P270
P321
P330
P405
P501
On the basis of an LD50 value of 90 mg/kg bw for rats (HSDB (2002)), it was classified in Category 3.
1 Acute toxicity (Dermal) Category 3

Danger
H311
P302+P352
P280
P312
P322
P361
P363
P405
P501
From an LD50 value of 250mg/kg for rats (RTECS (2003): original literature; World Review of Pest Control. (London, UK) 9, 119, 1970) , classification 'T; R24' in EU classification (EC-JRC (ESIS) (Access on June 2011)), it was classified in Category 3.
Besides, details of a reported LD50 value of 34 mg/kg for rabbits (RTECS (2003)) from List 3 information are unknown.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - It is a liquid at normal temperatures. (CRC (91st, 2010))
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - No data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - No data.
2 Skin corrosion/irritation Classification not possible - - - No data.
3 Serious eye damage/eye irritation Classification not possible - - - No data.
4 Respiratory sensitization Classification not possible - - - No data.
4 Skin sensitization Classification not possible - - - No data.
5 Germ cell mutagenicity Classification not possible - - - The classification is not possible due to no in vivo test data.
Besides, a negative in an Ames test is reported as an in vitro test. (NTP DB (1986))
6 Carcinogenicity Classification not possible - - - No data.
7 Reproductive toxicity Classification not possible - - - No data.
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system)

Warning
H371
P309+P311
P260
P264
P270
P405
P501
There is the information that a main acute poisoning symptom by thiocyanate pesticides is convulsions (HSDB (2002)), and there is the information that a principal systemic reaction by an exposure to aliphatic thiocyanates is probably central nervous depression interrupted by restlessness, hyperpnea, and tonic convulsions (HSDB (2002)).
In animal tests, rats showed coma, cyanosis, dyspnea, and tonic convulsions by oral administration at 90 mg/kg of this substance (DHP (13th, 2002)), and symptoms of tremors, paralysis, spasticity, and opisthotonos in rabbits in various administration routes are reported (HSDB (2002)).
From the above knowledge, all of which are from evaluation documents in List 2, it was classified in Category 2 (central nervous system).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - No data.
10 Aspiration hazard Classification not possible - - - No data.

ENVIRONMENTAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - H401
P273
P501
From 96-hour LC50 = 3.2 mg/L for fish (Oncorhynchus clarkii) (AQUIRE, 2012), it was classified in Category 2.
11 Hazardous to the aquatic environment (Long-term) Category 2
H411
P273
P391
P501
Reliable chronic toxicity data are not obtained.
Due to lack of rapid degradability (BIOWIN), and acute toxicity Category 2, it was classified in Category 2.
12 Hazardous to the ozone layer Classification not possible - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTES:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
   and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.



Updated date:
2016/9/2 Addition of Rationale for the classification

List of GHS Classification Results