GHS Classification Result

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GENERAL INFORMATION

Item Information
CAS number 2634-33-5
Chemical name 1,2-Benzothiazolin-3-one
Substance ID 23A5100
Fiscal year of classification conducted FY2011
Classifier(s) (Ministries) Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
New/Revised New
Download in Excel format Excel file

REFERENCE INFORMATION

Item Information
Guidance used for classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition)
Definitions / Abbreviations (Excel file) Definitions / Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Explosives Not applicable - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - "Solids" according to GHS definition.
3 Aerosols Not applicable - - - Not an aerosol product.
4 Oxidizing gases Not applicable - - - "Solids" according to GHS definition.
5 Gases under pressure Not applicable - - - "Solids" according to GHS definition.
6 Flammable liquids Not applicable - - - "Solids" according to GHS definition.
7 Flammable solids Classification not possible - - - No data.
8 Self-reactive substances and mixtures Not applicable - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - "Solids" according to GHS definition.
10 Pyrophoric solids Classification not possible - - - No data.
11 Self-heating substances and mixtures Classification not possible - - - No data.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - "Solids" according to GHS definition.
14 Oxidizing solids Not applicable - - - An organic compound that contains oxygen which is not chemically bonded to elements other than carbon or hydrogen.
15 Organic peroxides Not applicable - - - An organic compound that does not contain -O-O- structure.
16 Corrosive to metals Classification not possible - - - No established test method suitable for solid substances.

HEALTH HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Acute toxicity (Oral) Category 4

Warning
H302
P301+P312
P264
P270
P330
P501
All of 3 LD50 values for rats (900 to 1200 mg/kg, 670 mg/kg (males), and 784 mg/kg (females)) (DFGMAK-Doc. 2 (1991)) correspond to Category 4.
1 Acute toxicity (Dermal) Not classified - - - It was classified as "Not classified" from an LD value of > 2000 mg/kg bw due to no deaths in the administration of 2000 mg/kg to rats (DFGMAK-Doc. 2 (1991)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - "Solids" according to GHS definition.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - No data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - No data.
2 Skin corrosion/irritation Category 2

Warning
H315
P302+P352
P332+P313
P264
P280
P321
P362
In a skin irritation test in which 0.1 mL of preparation including 73.1% of this substance was applied to rabbits for 4 hours or 1 hour, it was assessed as an irritant in a 4-hour application. (DFGMAK-Doc. 2 (1991)).
On the other hand, in an occlusive test applied a solution of 500 to 1000 ppm in propylene glycol to 10 human volunteers for 24 hours, mild and visible redness of the skin shown in four persons and three persons reversed in 6 persons after 72 hours.
Furthermore, the second application after 1 to 2 weeks reported that eight persons showed slightly severe dermal reactions (erythema and papules). (DFGMAK-Doc. 2 (1991))
From the above test results on animals and humans, it was classified in Category 2.
Besides, it is classified in R38 in EU classification.
3 Serious eye damage/eye irritation Category 1

Danger
H318
P305+P351+P338
P280
P310
From a strong irritant evaluated by application of a concentration of 12.5% to rabbits (DFGMAK-Doc. 2 (1991)) and R41 classified in EU Classification (EC-JRC (ESIS) (Access on July 2011)), it was classified in Category 1.
4 Respiratory sensitization Classification not possible - - - No data.
4 Skin sensitization Category 1A

Warning
H317
P302+P352
P333+P313
P261
P272
P280
P321
P363
P501
This substance was classified as sensitizing from positive responses shown in 5 out of 15 persons (33%) in the last challenge test in a skin sensitization test using human volunteers. (DFGMAK-Doc. 2 (1991))
Also, there are many reports of occupational exposure observed positive responses as a result of skin application tests in workers having a skin disease such as dermatitis. (DFGMAK-Doc. 2 (1991))
It is reported that this substance has allergic effects to animals from a positive rate of 22% to 40% shown in a maximization test in guinea pigs. (DFGMAK-Doc. 2 (1991)).
Furthermore, it is listed as a sensitizing substance in Contact Dermatitis. (Frosch) (Contact Dermatitis (4th, 2006), corresponding to List 1)
From the above knowledge in which especially the positive responses of skin patch tests in humans with occupational exposure were frequently reported, it was classified in Category 1A.
5 Germ cell mutagenicity Not classified - - - From a negative result in a micronucleus test after oral administration in mice (in vivo mutagenicity test) (DFGMAK-Doc. 2 (1991)), it was classified as "Not classified."
Besides, as in vitro tests, both an Ames test and a mouse lymphoma test reported negative results. (DFGMAK-Doc. 2 (1991))
6 Carcinogenicity Classification not possible - - - Lack of data.
Besides, it is reported that a 2-year diet administration test at one concentration (0.1%) in 20 each of male and female rats did not show an increase in the tumor frequency compared to that in a control group without dosing. (DFGMAK-Doc. 2 (1991))
7 Reproductive toxicity Classification not possible - - - It was classified as "Classification not possible" due to unknown details on adverse fetal effects and no indicated specific data on effects on sexual function and fertility in a two-generation test using rats in which parent toxicity at 500 ppm and adverse effects on fetal development and survival at 1000 ppm were reported. (EPA RED (2005))
Besides, an oral administration test in pregnant rats during an organogenetic period reported that neither fetal toxicity nor teratogenicity was observed except decreased fetal body weights and slightly delayed ossification at the dose where general maternal toxicity such as abnormal respiratory noise, reduced weight gain, and reduced food consumption was shown. (DFGMAK-Doc. 2 (1991)).
8 Specific target organ toxicity - Single exposure Category 2 (nervous system)

Warning
H371
P309+P311
P260
P264
P270
P405
P501
Neurotoxicity was observed in an acute oral toxicity test such as piloerection and upward curvature of the spine at 300 mg/kg or higher, and decreased activity, prostration, a decrease in abdominal muscle tonus, reduced righting reflex, and decreased breathing rate at 900 mg/kg.
Because the doses based on the description correspond to Category 2 in Guidance values, it was classified in Category 2 (nervous system).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - In a 90-day diet administration test in rats (0.002 to 0.1%), neither hematological and biochemical changes were observed nor remarkable pathological signs were reported except reduced weights of liver and pituitary in the high-concentration group (0.1%).(DFGMAK-Doc. 2 (1991))
Furthermore, in a 90-day diet administration test in dogs (55 to 495 mg/kg/day), reduced food consumption, reduced weight gain, and mild anemia were shown, but other adverse effects were not observed, and NOEL of 165 mg/kg/day was reported. (DFGMAK-Doc. 2 (1991))
From the above results, it corresponds to "Not classified" in an oral route, but effects in other routes are unknown due to no data.
Therefore, it was classified as "Classification not possible" in specific target organ toxicity (repeated exposures).
10 Aspiration hazard Classification not possible - - - No data.

ENVIRONMENTAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1

Warning
H400
P273
P391
P501
It was classified in Category 1 from LC50 = 0.99 mg/L for crustacea (Mysidopsis bahia) (U.S. EPA: RED, 2005).
11 Hazardous to the aquatic environment (Long-term) Category 1

Warning
H410
P273
P391
P501
Reliable chronic toxicity data were not obtained.
Due to lack of rapid degradability (hardly degradable, a degradation rate by BOD: 0% (the existing chemicals survey program, 2003)), and acute toxicity Category 1, it was classified in Category 1.
12 Hazardous to the ozone layer Classification not possible - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTES:
* Hazard statement or Precautionary statement will show when hovering the mouse over a code of Hazard statement or Precautionary statement.
   Hazard statement and Precautionary statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
   and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.



Updated date:
  2017/1/30 Addition of Rationale for the classification

List of GHS Classification Results