GHS Classification Result

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GENERAL INFORMATION

Item Information
CAS number 297-97-2
Chemical name O,O-Diethyl O-(2-pyrazinyl) thiophosphate
Substance ID 23A5102
Fiscal year of classification conducted FY2011
Classifier(s) (Ministries) Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
New/Revised New
Download in Excel format Excel file

REFERENCE INFORMATION

Item Information
Guidance used for classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition）
Definitions / Abbreviations (Excel file) Definitions / Abbreviations
Model Label by MHLW (External link) MHLW Website （in Japanese Only）
Model SDS by MHLW (External link) MHLW Website （in Japanese Only）
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS

Hazard class Classification Symbol
Signal word 		Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - "Liquids" according to GHS definition.
3 Aerosols Not applicable - - - Not an aerosol product.
4 Oxidizing gases Not applicable - - - "Liquids" according to GHS definition.
5 Gases under pressure Not applicable - - - "Liquids" according to GHS definition.
6 Flammable liquids Classification not possible - - - No data.
7 Flammable solids Not applicable - - - "Liquids" according to GHS definition.
8 Self-reactive substances and mixtures Not applicable - - - Containing neither chemical groups related to explosibility nor those related to self-reactivity.
9 Pyrophoric liquids Classification not possible - - - No data.
10 Pyrophoric solids Not applicable - - - "Liquids" according to GHS definition.
11 Self-heating substances and mixtures Classification not possible - - - No established test method suitable for liquid substances.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Classification not possible - - - An organic compound that contains oxygen and the element is chemically bonded to phosphorus (P), but the classification is not possible due to no data.
14 Oxidizing solids Not applicable - - - "Liquids" according to GHS definition.
15 Organic peroxides Not applicable - - - An organic compound that does not contain -O-O- structure.
16 Corrosive to metals Classification not possible - - - No data.

HEALTH HAZARDS

Hazard class Classification Symbol
Signal word 		Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 2

Danger
 H300
 P301+P310
P264
P270
P321
P330
P405
P501
 On the basis of an LD50 value of 11 mg/kg for rats (PIM G001 (1998), equivalent to List 1), it was classified in Category 2.
1 Acute toxicity （Dermal） Category 1

Danger
 H310
 P302+P350
P262
P264
P270
P280
P310
P322
P361
P363
P405
P501
 On the basis of an LD50 value of 11 mg/kg for rats (HSDB (2003)), it was classified in Category 1.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - "Liquids" according to GHS definition.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - No data.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - No data.
2 Skin corrosion/irritation Classification not possible - - - No data.
3 Serious eye damage/eye irritation Classification not possible - - - No data.
4 Respiratory sensitization Classification not possible - - - No data.
4 Skin sensitization Classification not possible - - - No data.
5 Germ cell mutagenicity Classification not possible - - - No data.
6 Carcinogenicity Classification not possible - - - No data.
7 Reproductive toxicity Classification not possible - - - No data.
8 Specific target organ toxicity - Single exposure Classification not possible - - - No data.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - Lack of data.
Besides, "in ninety day feeding tests, rats fed on diets containing 25 - 50 ppm showed moderate depression in growth rate but no abnormal behavioral reactions" (1.25 - 2.5 mg/kg/day) (HSDB (2003)), and "thirty one and 90 day study with dogs fed 0.5 ppm to 25 ppm / thionazin / have been carried out indicating that no deaths occur at these levels" (0.125 - 0.625 mg/kg/day) (HSDB (2003)) are reported.
It was classified as "Classification not possible" because both of the findings are observed at a low dose within a range of guidance values and further details are unknown.
10 Aspiration hazard Classification not possible - - - No data.

ENVIRONMENTAL HAZARDS

Hazard class Classification Symbol
Signal word 		Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - The classification is not possible because appropriate data are not obtained.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - No data.
12 Hazardous to the ozone layer Classification not possible - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTES:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.



Updated date:
2016/7/13 Addition of Rationale for the classification

List of GHS Classification Results