Item | Information |
---|---|
CAS number | 541-42-4 |
Chemical name | Isopropyl nitrite |
Substance ID | 23A5111 |
Fiscal year of classification conducted | FY2011 |
Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
New/Revised | New |
Download in Excel format | Excel file |
Item | Information |
---|---|
Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition) |
Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not classified | - | - | - |
Because a marketed product contains a stabilizer, the classification "Not classified" is conceivable, though it contains a chemical group (N-O) associated with explosive properties. Besides, the sub-categorization is not possible because a pure form is an unstable substance (Many alkyl nitrites are thermally unstable and may readily decompose or explode on heating. Methyl nitrite explodes more violently than ethyl nitrite. Lower alkyl nitrites have been known to decompose and burst the container, even in refrigerated storage.) (Bretherick (7th, 2007)). |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | It is a liquid at normal temperatures (Dictionary of Organic Compounds (1985)). |
3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
4 | Oxidizing gases | Not applicable | - | - | - | It is a liquid at normal temperatures (Dictionary of Organic Compounds (1985)). |
5 | Gases under pressure | Not applicable | - | - | - | It is a liquid at normal temperatures (Dictionary of Organic Compounds (1985)). |
6 | Flammable liquids | Category 2 |
H225 |
P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
A flash point of < 10 degrees C [closed cup] (Bretherick (7th, 2007)), which is < 23 degrees C, and an initial boiling point of 39 degrees C (Merck (14th, 2006)), which is > 35 degrees C, correspond to Category 2. | |
7 | Flammable solids | Not applicable | - | - | - | It is a liquid at normal temperatures (Dictionary of Organic Compounds (1985)). |
8 | Self-reactive substances and mixtures | Type G | - | - | - |
Because a marketed product contains a stabilizer, the classification "Type G" is conceivable, though it contains a chemical group (N-O) associated with explosive properties. Besides, the sub-categorization is not possible because a pure form is an unstable substance (Many alkyl nitrites are thermally unstable and may readily decompose or explode on heating. Methyl nitrite explodes more violently than ethyl nitrite. Lower alkyl nitrites have been known to decompose and burst the container, even in refrigerated storage.) (Bretherick (7th, 2007)). |
9 | Pyrophoric liquids | Classification not possible | - | - | - | No data. |
10 | Pyrophoric solids | Not applicable | - | - | - | It is a liquid at normal temperatures (Dictionary of Organic Compounds (1985)). |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Classification not possible | - | - | - | An organic compound does not contain fluorine or chlorine but contains oxygen which is chemically bonded to nitrogen atoms, but the classification is not possible due to no data. |
14 | Oxidizing solids | Not applicable | - | - | - | It is a liquid at normal temperatures (Dictionary of Organic Compounds (1985)). |
15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
16 | Corrosive to metals | Classification not possible | - | - | - | No established test method suitable for liquid substances with a low boiling point. |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible | - | - | - | No data. |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | No data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | It is a liquid at normal temperatures (Dictionary of Organic Compounds (1985)). |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - |
Lack of data. Besides, an LC50 value of 1250 mg/m3/4h (343 ppm/4h) for rats (RTECS (2006)) was reported, but it is classified as "Classification not possible" due to the data from List 3 and unknown details. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | No data. |
2 | Skin corrosion/irritation | Classification not possible | - | - | - | No data. |
3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | No data. |
4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
4 | Skin sensitization | Classification not possible | - | - | - | No data. |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | No data. |
6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
8 | Specific target organ toxicity - Single exposure | Category 1 (cardiovascular system, blood system, nervous system) |
H370 |
P307+P311 P260 P264 P270 P321 P405 P501 |
There is information about nitrites that inhalation of high concentration relaxes smooth muscle, and the consequent intense peripheral vasodilation produces flushing, a fall in blood pressure, and a reflex increase in heart rate to maintain perfusion of vital organs (NIDA Research Monograph 83 (1988)), and that nervous system symptoms such as a headache, dizziness, ataxia, syncope, sedative action, a sense of weakness are observed (meeting material of the Committee on Designated Substances, Pharmaceutical Affairs and Food Sanitation Council, MHLW (2006)), therefore, it was classified in Category 1 (cardiovascular system, nervous system). Furthermore, effects of this substance on blood are also indicated from the information that nitro compounds such as nitrate and nitrite cause methemoglobinemia to animals (PATTY (5th, 2001)), side effects of medical isopentyl nitrite includes methemoglobinemia, cyanosis, and hemolytic anemia (Ethical pharmaceuticals (2010)), and butyl nitrites have a feature of methemoglobin formation in mice (NIDA Research Monograph 83 (1988)), therefore, it was classified in Category 1 (blood system). |
|
9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | No data. |
10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible | - | - | - | No data. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible | - | - | - | No data. |
12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
2016/8/17 Addition of Rationale for the classification |