GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 66-76-2 |
| Chemical name | 4,4'-Dihydroxy-3,3'-methylenedi-2H-chromen-2-one |
| Substance ID | 23A5118 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 6 | Flammable liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 7 | Flammable solids | Classification not possible | - | - | - | No data. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 10 | Pyrophoric solids | Classification not possible | - | - | - | No data. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No data. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 14 | Oxidizing solids | Not applicable | - | - | - | An organic compound that does not contain fluorine or chlorine but contains oxygen which is not chemically bonded to elements other than carbon or hydrogen. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No established test method suitable for solid substances. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |  |
H301 |
P301+P310 P264 P270 P321 P330 P405 P501 |
On the basis of an LD50 value of 250 mg/kg bw for rats (HSDB (2003)), it was classified in Category 3. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | No data. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | No data. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | No data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | No data. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - |
Lack of data. Besides, there is one case where a pregnant woman who was dosed this substance during pregnancy (as an anticoagulant medication) delivered a child with a cleft palate (Teratogenic (12th, 2007), corresponding to List 2), and this substance is listed in Chemicals Identified Under California Proposition 65 as Developmentally Toxic (Birth Defects (3rd, 2000), corresponding to List 2), but it was classified as "Classification not possible" due to unknown details in both. |
| 8 | Specific target organ toxicity - Single exposure | Category 2 (blood) |  |
H371 |
P309+P311 P260 P264 P270 P405 P501 |
Bleeding is the major toxicity of this substance used as an anticoagulant medication, and especially, irreversible damage of serious events may result from compression of intracranial, pericardial, nerve sheath, and so on, or from massive internal bleeding (HSDB (2003)). On the basis that "acute clinical effects depend on the site of hemorrhage and include hemoptysis, hematuria, gastrointestinal bleeding, abdominal or back pain (retroperitoneal hemorrhage), hemarthrosis, and cerebrovascular accidents" (HSDB (2003)), it was classified in Category 2 (blood) due to list 2 information. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (blood) | |
H373 |
P260 P314 P501 |
Bleeding is the major toxicity of this substance used as an anticoagulant medication, and especially, irreversible damage of serious events may result from compression of intracranial, pericardial, nerve sheath, and so on, or from massive internal bleeding (HSDB (2003)). A hemorrhagic diathesis was observed in calves fed the hay containing this substance, and the animals showed increased prothrombin and partial thromboplastin times, weakness, stiff gait, tachycardia, tachypnea, hematomata, and sudden deaths. The absence of blood coagulation was seen at necropsy, hemorrhages were observed in most organs, and this substance was detected in the serum (HSDB (2003)). From the above knowledge, it was classified in Category 2 (blood) due to list 2 information. Besides, it is classified in T; R48 in EU classification (EC-JRC (ESIS) (Access on July. 2011)). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 2 | - |
H401 |
P273 P501 |
It was classified in Category 2 from 96-hour LC50 = 5.11 mg/L for fish (Pimephales promelas) (AQUIRE, 2012; HSDB, 2003). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 2 |  |
H411 |
P273 P391 P501 |
Reliable chronic toxicity data are not obtained. Because appropriate data on rapid degradability was not obtained and it was classified in Category 2 in acute toxicity, it was classified in Category 2. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/8/17 Addition of Rationale for the classification |