GHS Classification Result

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GENERAL INFORMATION

Item Information
CAS number 41593-38-8
Chemical name Propylene glycol phenyl ether (mixed isomer)
Substance ID 23A5128
Fiscal year of classification conducted FY2011
Classifier(s) (Ministries) Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
New/Revised New
Download in Excel format Excel file

REFERENCE INFORMATION

Item Information
Guidance used for classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition)
Definitions / Abbreviations (Excel file) Definitions / Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Explosives Not applicable - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - "Liquids" according to GHS definition.
3 Aerosols Not applicable - - - Not an aerosol product.
4 Oxidizing gases Not applicable - - - "Liquids" according to GHS definition.
5 Gases under pressure Not applicable - - - "Liquids" according to GHS definition.
6 Flammable liquids Not classified - - - A flash point of 120 degrees C [closed cup] (SIDS (2004)) is above 93 degrees C.
7 Flammable solids Not applicable - - - "Liquids" according to GHS definition.
8 Self-reactive substances and mixtures Not applicable - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - It is conceivable that it does not ignite at normal temperatures from an ignition point of 490 degrees C (SIDS (2004)).
10 Pyrophoric solids Not applicable - - - "Liquids" according to GHS definition.
11 Self-heating substances and mixtures Classification not possible - - - No established test method suitable for liquid substances.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - An organic compound does not contain fluorine or chlorine but contains oxygen which is not chemically bonded to elements other than carbon or hydrogen.
14 Oxidizing solids Not applicable - - - "Liquids" according to GHS definition.
15 Organic peroxides Not applicable - - - An organic compound that does not contain -O-O- structure.
16 Corrosive to metals Classification not possible - - - No data.

HEALTH HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - On the basis of 3 LD50 values for rats (>2000 mg/kg, 2830 mg/kg (males), 3730 mg/kg (females)) (SIDS (2004)), it was classified as "Not classified" in JIS classification (corresponding to Category 5 in UN GHS classification).
1 Acute toxicity (Dermal) Not classified - - - From no death after administration at 2000 mg/kg and an LD50 value of >2000 mg/kg bw in rats (SIDS (2004)), it was classified as "Not classified."
1 Acute toxicity (Inhalation: Gases) Not applicable - - - "Liquids" according to GHS definition.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - No data.
1 Acute toxicity (Inhalation: Dusts and mists) Not classified - - - From no death after a 4-hour exposure to 5.4 mg/L (mist) (OECD TG 403; GLP) and an LC50 value of >5.4 mg/L/4h in rats (SIDS (2004)), it was classified as "Not classified."
2 Skin corrosion/irritation Not classified - - - In a semi-occlusive test applied 0.5 mL of undiluted this substance to 3 rabbits for 4 hours (OECD TG 404; GLP), the only irritation score higher than 0 was an erythema score of 1 in 1 animal observed 30 to 60 minutes after a removal of a patch. A score of 0 in all animals observed after 24, 48, and 72 hours resulted in not irritating. (SIDS (2004))
Therefore, it was classified as "Not classified."
3 Serious eye damage/eye irritation Category 2A

Warning
H319
P305+P351+P338
P337+P313
P264
P280
In a test applied 0.1 mL of undiluted this substance to eyes of 3 rabbits (OECD TG 405; GLP), average scores in 3 animals at time points of 24, 48, and 72 hours after application were 1 for corneal opacity, 0.4 for iritis, 2.0 for conjunctival redness, and 0.9 for chemosis. And it was assessed as highly irritating from a score of 1 in corneal opacity and scores of 2 and 3 in conjunctival redness observed in 2 out of 3 animals after 23 days. (SIDS (2004))
Threfore, it was classified in Category 2A.
Besides, another test applied undiluted this substance to eyes of 3 rabbits reported that produced slight conjunctival irritation, and slight and transient corneal injury reversed within a few days to 1 week. (ECETOC 95 (2005))
4 Respiratory sensitization Classification not possible - - - No data.
4 Skin sensitization Not classified - - - On the basis that it was not sensitizing as a result of a skin sensitization test using guinea pigs (Buehler method: OECD TG 406, GLP) with a positive rate of 0% (0/20) (SIDS (2004)), it was classified as "Not classified."
5 Germ cell mutagenicity Not classified - - - In a micronucleus test using bone marrow after an oral administration to mice (in vivo somatic cell mutagenicity test), the slightly increased frequency of micronuclei in animals in a high dose group (2000 mg/kg) was statistically significant in the first test but was not significant in the second (indicated a similar tendency).
The author of this study attributed this fact to hypothermia. Causing hypothermia only in animals at the high dose and increased micronuclei as its indirect effects were clarified by other chemicals.
It seems reasonable to conclude that the negative in vitro results and the equivocal in vivo results at a very high dose level that may be due to physiological stress indicate that propylene glycol phenyl ether does not pose a genotoxicity hazard at a possible exposure dose in the environment (SIDS (2004)).
From the above information, it was classified as "Not classified."
Besides, an Ames test and a chromosomal aberration test using human lymphocytes resulted in negatives as in vitro tests (SIDS (2004)).
6 Carcinogenicity Classification not possible - - - No data.
7 Reproductive toxicity Not classified - - - In a two-generation reproductive toxicity test by drinking water administration to rats (OECD TG 416, GLP), no adverse effects on fertility and reproductive organs/tissue in each generation at a dose (5000 ppm) where general toxicity (decreases in water and food consumption, decreased body weight gain) was observed in parent animals, and no adverse developmental effects except decreased body weight, changes in organ weights, and delayed sexual maturation in fetuses at the same dose were reported. (SIDS (2004))
Besides, in an oral administration test to pregnant rabbits during an organogenetic period (OECD TG 414, GLP), no adverse developmental effects including teratogenicity except increased skeletal variations in fetuses (an increase in 13th ribs) at a dose (540 mg/kg/day) where maternal animals showed general toxicity (decreases in food consumption and body weight gain) were observed (SIDS (2004)).
From the above, it was classified as "Not classified" because neither adverse effects on sexual function and fertility nor fetal development was observed.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects)

Warning
H336
P304+P340
P403+P233
P261
P271
P312
P405
P501
A death of a male in a 1000 mg/kg group and toxic signs of apathy, staggering gait, atonia, and absence of pain and corneal reflex after oral administration of 1000 and 2000 mg/kg (5 each of male and female rats per each dose) to rats were described.
And the disappearance of these signs on the day of administration or later was reported. (SIDS (2004))
Therefore, it was classified in Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - In a two-generation reproductive toxicity test by oral administration to rats for 26 weeks (drinking water) (OECD TG 416: GLP), no serious effects observation in parent animals and NOAEL of 1000 ppm (114 mg/kg/day) were reported. (SIDS (2004))
Besides, in a 28-week dermal administration toxicity test using rabbits, a NOAEL of 1000 mg/kg/day (converted to a 90-day equivalent: 311 mg/kg/day) was reported. (SIDS (2004))
NOAELs above the upper limit in Guidance values in both oral and dermal routes correspond to "Not classified," but the classification not possible due to no data on inhalation route.
10 Aspiration hazard Classification not possible - - - No data.

ENVIRONMENTAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - From above 100 mg/L in the acute toxicity tests for fish, crustacea, and algae (SIDS 2004), it was classified as "Not classified."
11 Hazardous to the aquatic environment (Long-term) Not classified - - - If chronic toxicity data are used, then it is classified as "Not classified" from 72-hour NOEC = 12.5 mg/L for algae (Scenedesmus subspicatus) (SIDS (2004)) despite not obtaining appropriate data on rapid degradability.
If acute toxicity data are used for trophic levels for which chronic toxicity data are not obtained, then it is classified as "Not classified" because acute toxicity for both crustacea and fish corresponds to "Not classified" and it is not water-insoluble (water solubility = 10,000 mg/L, SIDS (2004)).
From the above results, it was classified as "Not classified."
12 Hazardous to the ozone layer Classification not possible - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTES:
* Hazard statement or Precautionary statement will show when hovering the mouse over a code of Hazard statement or Precautionary statement.
   Hazard statement and Precautionary statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
   and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.



Updated date:
2016/12/19 Addition of Rationale for the classification

List of GHS Classification Results