GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 98-06-6 |
| Chemical name | tert-Butylbenzene |
| Substance ID | 23A5132 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Category 3 |  |
H226 |
P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
A flash point of 44 degrees C [closed cup] (GESTIS (Access on Aug. 2011)), which is >= 23 degrees C and <= 60 degrees C, corresponds to Category 3. Besides, it is classified in class 3PGIII in UNRTDG (UN2709 butyl benzenes). |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition point of 450 degrees C (Sax (11th, 2004)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound does not contain oxygen, fluorine, or chlorine. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | All of reporeted LD50 values of 3503 mg/kg (HSDB (2010)), 4372 mg/kg and 2500 to 5000 mg/kg (both BUA 234 (2001)) for rats correspond to "Not classified" in JIS classification (Category 5 in UN GHS classification). |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | From no death at the administration of 2000 mg/kg and an LD50 value of >2000 mg/kg bw in rats (HSDB (2010)), it was classified as "Not classified." |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 3 |  |
H331 |
P304+P340 P403+P233 P261 P271 P311 P321 P405 |
From an LC50 value of 4.6 mg/L/4h for rats (838 ppm) (HSDB (2010)), it was classified in Category 3. Besides, a reference value of gasses as vapour with hardly included mist is applied because the LC50 value (838 ppm) is lower than 90 % of the saturated vapour pressure concentration (2895 ppm). |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Category 2 |  |
H315 |
P302+P352 P332+P313 P264 P280 P321 P362 |
On the basis that it was assessed as severely irritating with a primary irritation index of 5.4 (maximum 8) in an occlusive test (OECD TG 404) applied 0.5 mL of undiluted this substance to rabbits for 4 hours (BUA 234 (2001)), it was classified in Category 2. |
| 3 | Serious eye damage/eye irritation | Not classified | - | - | - |
In a test dropped 0.1 mL of undiluted this substance to 3 rabbits (OECD TG 405), corneal opacity and iritis were not observed. The conjunctival redness of grade 2 in two animals and grade 1 in one animal, and chemosis in two animals (score: 0.67, 1.33) reversed within eight days. And a primary irritation index (equivalent to AOI) was 5.5 (/110) less than 15. (BUA 234 (2001)) Therefore, it was classified as "Not classified." |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Not classified | - | - | - |
In a maximization test in guinea pigs (OECD TG 406), no skin reactions in any animals in a challenge with this substance (30% solution) was observed. And a positive rate was 0% (0/20). And it was concluded that it is not sensitizing to this substance in the maximization test in guinea pigs. (BUA 234 (2001)) Therefore, it was classified as "Not classified." |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, a negative in an Ames test (BUA 234 (2001)) and a negative in a chromosomal aberration test using rat hepatocytes (HSDB (2010)) were reported as in vitro tests. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
| 8 | Specific target organ toxicity - Single exposure | Category 2 (nervous system) |  |
H371 |
P309+P311 P260 P264 P270 P405 P501 |
Neurotoxicity of this substance is considered to be caused by the hemorrhage in the spinal cord due to vascular injury. Irreversible forelimb paralysis was reported at 0.075 mL (65 mg) in the single oral administration to rats (PATTY (5th, 2001), and the dose of 65 mg in oral administration, which converted to 325 to 650 mg/kg if a rat body weit is 100 to 200 g, correspond to Category 2 in Guidance values. Besides, in an inhalation exposure test (vapour) (4.0 to 4.6 mg/L) in rats, nervous symptoms such as abnormal gait, tremor, fasciculation, and convulsions were observed (HSDB (2010)). The test concentration corresponds to Category 1 in Guidance values, but it corresponds to Category 2 because data are from List 2 and do not meet Decision Criteria 1b3) (OECD TG and GLP). Therefore, it was classified in Category 2 (nervous system). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | No data. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | The classification is not possible because appropriate data are not obtained. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Hazard statement or Precautionary statement will show when hovering the mouse over a code of Hazard statement or Precautionary statement. Hazard statement and Precautionary statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/12/19 Addition of Rationale for the classification |