GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 13755-38-9 |
| Chemical name | Sodium pentacyanonitrosylferrate(III) dihydrate |
| Substance ID | 23A5133 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | It is a solid (crystals) at normal temperatures (Merck (14th, 2006)). |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | It is a solid (crystals) at normal temperatures (Merck (14th, 2006)). |
| 5 | Gases under pressure | Not applicable | - | - | - | It is a solid (crystals) at normal temperatures (Merck (14th, 2006)). |
| 6 | Flammable liquids | Not applicable | - | - | - | It is a solid (crystals) at normal temperatures (Merck (14th, 2006)). |
| 7 | Flammable solids | Classification not possible | - | - | - | No data. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | It is a solid (crystals) at normal temperatures (Merck (14th, 2006)). |
| 10 | Pyrophoric solids | Classification not possible | - | - | - | No data. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No data. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | It contains a metal (Fe), but it is classified as "not classified" because it is conceivable that it is stable in the water from water solubility data of 40 g/100 mL (CRC (91st, 2010)). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | It is a solid (crystals) at normal temperatures (Merck (14th, 2006)). |
| 14 | Oxidizing solids | Classification not possible | - | - | - | An inorganic compound contains oxygen which is chemically bonded to nitrogen, but the classification is not possible due to no data. |
| 15 | Organic peroxides | Not applicable | - | - | - | It is an inorganic compound. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |  |
H301 |
P301+P310 P264 P270 P321 P330 P405 P501 |
From an LD50 value of 113 mg/kg as a dihydrate converted from a reported LD50 value of 99 mg/kg as an anhydrate for rats (RTECS (2010): original literature; Arzneimittel-Forschung. Drug Research: 24, 308, 1974), it was classified in Category 3. Besides, the data was confirmed with the obtained original literature though it was from List 3 data. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | It is a solid (crystals) at normal temperatures (Merck (14th, 2006)). |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - |
No data. Besides, there is the information that cyanides are weakly irritating to skin (CICAD 61 (2004)). |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - |
No data. Besides, there is the information that cyanides are weakly irritating to eyes (CICAD 61 (2004)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | No data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | No data. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - |
As information on an anhydrate, it is reported that no teratogenicity in intravenous administration to rats and rabbit (Teratogenic (12th, 2007), corresponding to List 2), no adverse fetal effects in intravenous administration during an organogenesis in rabbits (Teratogenic (12th, 2007)), and no adverse fetal and postnatal development effects in reproduction, teratology, and perinatal studies in intravenous administration in rats (Teratogenic (12th, 2007)) were found. But all of them were intravenous administration and unknown details of the test method and test results, therefore, it was classified as "Classification not possible." |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - |
Lack of data. Besides, this substance is used as a blood pressure lowering medication and is administered intravenously. Hypotension, hepatic dysfunction, tachycardia and so on are known as main adverse effects. And abnormal changes in clinical tests such as abnormality on liver function tests, a drop of blood pressure, elevated C-reactive protein, low PO2, and leukocytosis were reported (Ethical pharmaceuticals (2010), corresponding to List 1). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - |
No data. Besides, there is the information that the primary target organs of toxicity by cyanide formed in the body after administration of an anhydrate are the cardiovascular, respiratory, and central nervous systems. And the endocrine system is a potential target of long-term toxicity in repeated exposures because the metabolite, thiocyanate, acts as a goitrogenic agent to prevent the uptake of iodine in the thyroid. (CICAD 61 (2004)) |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | No data. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Hazard statement or Precautionary statement will show when hovering the mouse over a code of Hazard statement or Precautionary statement. Hazard statement and Precautionary statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/12/19 Addition of Rationale for the classification |