GHS Classification Result

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GENERAL INFORMATION

Item Information
CAS number 12060-00-3
Chemical name Lead titanate
Substance ID 23A5135
Fiscal year of classification conducted FY2011
Classifier(s) (Ministries) Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
New/Revised New
Download in Excel format Excel file

REFERENCE INFORMATION

Item Information
Guidance used for classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition)
Definitions / Abbreviations (Excel file) Definitions / Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Explosives Not applicable - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - It is a solid at normal temperatures. (Sax (11th, 2004))
3 Aerosols Not applicable - - - Not an aerosol product.
4 Oxidizing gases Not applicable - - - It is a solid at normal temperatures. (Sax (11th, 2004))
5 Gases under pressure Not applicable - - - It is a solid at normal temperatures. (Sax (11th, 2004))
6 Flammable liquids Not applicable - - - It is a solid at normal temperatures. (Sax (11th, 2004))
7 Flammable solids Not classified - - - It is "non combustible." (MSDS (Sigma-Aldrich))
8 Self-reactive substances and mixtures Not applicable - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - It is a solid at normal temperatures. (Sax (11th, 2004))
10 Pyrophoric solids Not classified - - - It is "non combustible." (MSDS (Sigma-Aldrich))
11 Self-heating substances and mixtures Not classified - - - It is "non combustible." (MSDS (Sigma-Aldrich))
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - It contains metals (Pb, Ti), but the classification is not possible due to no data.
13 Oxidizing liquids Not applicable - - - It is a solid at normal temperatures. (Sax (11th, 2004))
14 Oxidizing solids Classification not possible - - - An inorganic compound which does not contain halogens but contains oxygen.
But the classification is not possible due to no data.
15 Organic peroxides Not applicable - - - It is an inorganic compound.
16 Corrosive to metals Classification not possible - - - No established test method suitable for solid substances.

HEALTH HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - From a reported LD50 value of >12000 mg/kg for rats (JECFA 150 (1969)), it was classified as "Not classified."
Besides, refer to health hazards of other inorganic lead compounds and inorganic titanium compounds as analog compounds.
1 Acute toxicity (Dermal) Classification not possible - - - No data.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - "Solids" according to GHS definition.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - No data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - No data.
2 Skin corrosion/irritation Classification not possible - - - No data.
Besides, as effects on humans, DFG says that there are no available data on the local effects of lead or inorganic lead compounds on skins and mucous membranes (DFGMAK-Doc. 17 (2002)), but HSDB says that it can cause severe irritation and burns to skins (HSDB (2010)).
3 Serious eye damage/eye irritation Classification not possible - - - No data.
Besides, as effects on humans, DFG says that there are no available data on the local effects of lead or inorganic lead compounds on mucous membranes (DFGMAK-Doc. 17 (2002)), but HSDB says that it can cause severe irritation and burns to eyes (HSDB (2010)).
4 Respiratory sensitization Classification not possible - - - No data.
4 Skin sensitization Classification not possible - - - No data.
5 Germ cell mutagenicity Classification not possible - - - No data.
Positive and negative results in chromosomal aberration tests using lymphocytes of workers with occupational exposure to lead have a remark that genotoxicity cannot be assessed as a whole because most of the tests were inadequate (DFGMAK-Doc. 17 (2002)).
On the other hand, inorganic lead compounds are classified in 3A in germ cell mutagenicity in MAK/BAT (2010).
6 Carcinogenicity Category 1B

Danger
H350
P308+P313
P201
P202
P281
P405
P501
It was classified in Category 1B because it is classified in Group 2A as an inorganic lead compound in an IARC carcinogenicity evaluation (IARC 87 (2006)).
Besides, it is classified in 2B as a lead compound in Japan Society for Occupational Health (The Recommendation of Acceptable Concentration of the Japan Society for Occupational Health (2011)) and is classified in A3 as an inorganic lead compound in ACGIH (ACGIH (2001)).
7 Reproductive toxicity Category 1A

Danger
H360
P308+P313
P201
P202
P281
P405
P501
There are no data on this substance.
But as effects of inorganic lead compounds on humans, case studies and epidemiology studies reported that increased risk for spontaneous abortion by maternal exposure to high concentrations before the 20th week of gestation was observed, and prenatal exposure was associated with an increased risk of malformation, low birth weight, and reduced postnatal growth rate. (IARC 87 (2006)).
Therefore, it was classified in Category 1A.
But toxicity to sperm was reported to be unclear because a dose-response relationship between the level of lead exposures and effects observed in occupational exposure such as reduced sperm counts and sperm volume, reduced sperm motility and morphological changes in the sperms cannot be derived from the results of most of the studies. (DFGMAK-Doc. 17 (2002))
8 Specific target organ toxicity - Single exposure Category 1 (kidney, nervous system, digestive system, blood system)

Danger
H370
P307+P311
P260
P264
P270
P321
P405
P501
There are no data on this substance.
Because neurotoxic effects of lead were well recognized, both the peripheral and central nervous system are targets for the lead, lead encephalopathy is one of the early symptoms of acute lead poisoning, and wrist drop and slowing nerve conduction velocities in occupational exposures were reported. (IARC 87 (2006)), it was classified in Category 1 (nervous system).
From the information that acute exposure to high concentrations of lead and inorganic lead compounds results in dysfunction of the proximal tubule and renal manifestations of acute lead poisoning includes the Fanconi syndrome (glycosuria, aminoaciduria, phosphaturia, and so on) (IARC 87 (2006)), it was classified in Category 1 (kidney).
Furthermore, from the information that lead, which is known to alter the hematological system, inhibits delta-aminolevulinic acid and heme synthesis and consequently causes inhibition of heme synthesis and shortening of the erythrocyte lifespan which results in microcytic and hypochromic anemia (ATSDR (2007)), it was classified in Category 1 (blood system).
And from the information that colic which is a consistent early symptom of lead poisoning in occlupationally exposed cases or in individuals acutely exposed to high levels of lead is accompanied by symptoms such as constipation, abdominal pain, nausea, vomiting, anorexia, and body weight loss (ATSDR (2007)), it was classified in Category 1 (digestive system).
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney, blood system, cardiovascular system, nervous system)

Danger
H372
P260
P264
P270
P314
P501
There are no data on this substance.
From the information that repeated exposure to high concentration of lead and inorganic lead compounds causes irreversible changes in the kidney including tubular atrophy, interstitial fibrosis, and glomerular sclerosis, and ultimately chronic renal failure (IARC 87 (2006)), it was classified in Category 1 (kidney).
Besides, form the report of an epidemiological study in patients with lead poisoning in which hemoglobin and hematocrit were significantly decreased in the patients compared to unexposed control subjects (ATSDR (2007)), and the information that lead inhibits delta-aminolevulinic acid and heme synthesis and consequently causes inhibition of heme synthesis and shortening of the erythrocyte lifespan which results in microcytic and hypochromic anemia (ATSDR (2007)), it was classified in Category 1 (blood system).
On the other hand, a study which supported a relationship between chronic lead poisoning and myocardial damage reported electrocardiographic abnormality in workers with lead poisoning (ACGIH (2001)), and analyses of epidemiological data led to a conclusion that lead absorption causes a statistically significant increase in both systolic and diastolic blood pressure (ACGIH (2001)), therefore, it was classified in Category 1 (cardiovascular system).
Furthermore, from decreased motor nerve conduction velocities observed in workers with high blood lead concentrations (ACGIH (2001)), and a report of parkinsonian syndromes observed in 7 out of 9 workers exposed to lead batteries over 30 years (NICNAS (2007)), it was classified in Category 1 (nervous system).
10 Aspiration hazard Classification not possible - - - No data.

ENVIRONMENTAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - No data.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - No data.
12 Hazardous to the ozone layer Classification not possible - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTES:
* Hazard statement or Precautionary statement will show when hovering the mouse over a code of Hazard statement or Precautionary statement.
   Hazard statement and Precautionary statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
   and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.



Updated date:
2016/12/19 Addition of Rationale for the classification

List of GHS Classification Results