GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 91465-08-6 |
| Chemical name | Lambda-cyhalothrin |
| Substance ID | 23A5147 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 6 | Flammable liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 7 | Flammable solids | Classification not possible | - | - | - | No data. |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | There is a chemical group present in the molecule associated with a self-reactive property (strained ring), but the classification is not possible due to no data. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 10 | Pyrophoric solids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition point of 375 to 385 degrees C (GESTIS (Access on Oct. 2011)). |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for a solid with a melting point of 140 degrees C or lower. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 14 | Oxidizing solids | Not applicable | - | - | - | An organic compound contains oxygen, fluorine, and chlorine and these elements are not chemically bonded to elements other than carbon or hydrogen. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | The classification is not possible because a solid with a melting point of 55 degrees C or lower has no data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |  |
H301 |
P301+P310 P264 P270 P321 P330 P405 P501 |
From LD50 values of 56 to 79 mg/kg for rats (EHC 99 (1990)), it was classified in Category 3. |
| 1 | Acute toxicity （Dermal） | Category 3 | |
H311 |
P302+P352 P280 P312 P322 P361 P363 P405 P501 |
From LD50 values of 632 to 696 mg/kg for rats (EHC 99 (1990)), it was classified in Category 3. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Not classified | - | - | - |
An occlusive application test to rabbit skins resulted in "non-irritant" (EHC 99 (1990)), but another test using rabbit reported "mild irritant." In addition, an epidemiological survey of workers of manufacturing agricultural chemicals reported skin irritation as a transient effect disappeared within 24 hours. From the above, it was classified as "Not classified" in JIS classification (Category 3 in UN GHS classification). |
| 3 | Serious eye damage/eye irritation | Category 2B |
H320 |
P305+P351+P338 P337+P313 P264 |
From "mild irritant" reported in a test using rabbits (EHC 99 (1990)), it was classified in Category 2B. | |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Not classified | - | - | - | From "no sensitization potential" reported in a maximization test in guinea pigs (EHC 99 (1889)) and being assessed as not sensitizing in guinea pigs (HSGs (1990), corresponding to List 1), it was classified as "Not classified." |
| 5 | Germ cell mutagenicity | Not classified | - | - | - |
From a negative result in a micronucleus test using mouse bone marrow cells (in vivo somatic cell mutagenicity test) (EHC 99 (1990)), it was classified as "Not classified." Besides, negative results in all of an Ames test, a gene mutation test using L51787 mouse lymphoma cells, and a chromosomal aberration test using human lymphocytes were obtained as in vitro tests (above EHC 99 (1990)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system), Category 3 (respiratory tract irritation) |   |
H370 H335 |
P307+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
It is said that a poisoning symptom of this substance is characterized by type II pyrethroid toxicity. Signs of piloerection, subdued behavior, ataxia, unsteady gait, incontinence, exploratory behavior, and so on were observed in the oral administration to rats and mice (LD50 values: 56 to 79 mg/kg for rats and 19.9 mg/kg for mice), and same signs were shown in the dermal administration to rats (LD50 values: 632 to 696 mg/kg). (EHC 99 (1990)) Because the doses are within a range of Category 1 in guidance values judging from LD50 values, it was classified in Category 1 (nervous system). Furthermore, it was classified in Category 3 (respiratory tract irritation) because a human epidemiological survey reported irritation to nose and throat accompanied by a cough and sneezing as the most common signs via an exposure by using insecticides containing this substance (JECFA .53 (2004)). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system) | |
H372 |
P260 P264 P270 P314 P501 |
This substance, which is a type II pyrethroid, has basically the same mode of action as other pyrethroids. (EHC 99 (1990)) On the basis that 52-week oral administration in dogs reported clear clinical signs showing neurological effects without changes in nervous tissues in all animals at a dose of 3.5 mg/kg/day corresponding to Category 1 in Guidance values (EHC 99 (1990)), it was classified in Category 1 (nervous system). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |  |
H400 |
P273 P391 P501 |
It was classified in Category 1 from 48-hour LC50 = 90 ng/L for crustacea (Daphnia magna), 48-hour LC50 = 7.5 ng/L for crustacea (Mysidopsis bahia), and so on (EHC 99, 1990). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 | |
H410 |
P273 P391 P501 |
It was classified in Category 1 due to lack of rapid degradability (BIOWIN) and 21-day NOEL = 2.5 ng/L for crustacea (Daphnia magna) (EHC 99, 1990). |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/11/16 Addition of Rationale for the classification |