GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 826-36-8 |
| Chemical name | 2,2,6,6-Tetramethylpiperidin-4-one |
| Substance ID | 23A5160 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 6 | Flammable liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 7 | Flammable solids | Classification not possible | - | - | - | No data. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 10 | Pyrophoric solids | Classification not possible | - | - | - | No data. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for solid substances with a melting point of 140 degrees C or lower. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 14 | Oxidizing solids | Not applicable | - | - | - | An organic compound does not contain fluorine or chlorine but contains oxygen which is not chemically bonded to elements other than carbon or hydrogen. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | The classification is not possible because a solid with a melting point of 55 degrees C or lower has no data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |  |
H302 |
P301+P312 P264 P270 P330 P501 |
From LD50 values of 1000 to 2000 mg/kg ((IUCLID (2000), Directive 84/449/EEC, B.1, GLP) and 1330 mg/kg (BUA Report 255 (2006), OECD TG401) for rats, it was classified in Category 4. |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | From an LD50 value of >2000 mg/kg and no deaths in rats (IUCLID (2000), OECD TG 402, GLP), it was classified as "Not classified." |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Category 1 |  |
H314 |
P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
On the basis that a test (OECD TG 404) applied 500 mg to rabbit skin for 4 hours observed severe necrosis was discontinued due to severe damages after 24 hours and this substance was assessed as caustic as a result (BUA Report 255 (2006)), it was classified in Category 1. Furthermore, another test applied 500 mg to only a rabbit (OECD TG 404) was discontinued due to severe necrosis after 72 hours (BUA Report 255 (2006)), and it was also assessed as caustic. |
| 3 | Serious eye damage/eye irritation | Category 1 | |
H318 |
P305+P351+P338 P280 P310 |
Due to severe damages, a test (OECD TG 405) applied 100 mg used only 1 rabbit was discontinued after 72 hours. On the basis that an irritation index was 38 against maximum 110, a detachment of the mucous membrane and corrosion were observed in the conjunctival sac, and it was assessed as caustic as a result (BUA Report 255 (2006)), it was classified in Category 1. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Category 1 | |
H317 |
P302+P352 P333+P313 P261 P272 P280 P321 P363 P501 |
On the basis that a guinea pig maximization test (OECD TG 406), in which erythema and edema in all animals in a challenge were observed (a positive rate 100% (20/20)), reported highly sensitizing (BUA Report 255 (2006)), it was classified in Category 1. Furthermore, another guinea pig maximization test (Directive 84/449/EEC, B.6, GLP) reported a sensitizing result (IUCLID (2000)). |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, an Ames test (Directive 84/449/EEC, B.10, GLP) reported a negative result as an in vitro test (IUCLID (2000)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
| 8 | Specific target organ toxicity - Single exposure | Category 2 (cardiovascular system, nervous system) |  |
H371 |
P309+P311 P260 P264 P270 P405 P501 |
From the List 2 information that the reduction of blood pressure due to vasodilation as a result of inhibition of vasomotor nerves was considered to be caused by this substance (BUA Report 255 (2006), it was classified in Category 2 (cardiovascular system). In addition, because poisoning signs such as nervousness, tremor, and staggering followed by sedation, ataxia, dyspnea, hypothermia, a prone position, and jerking after 30 minutes and an LD50 value of 1350 mg/kg were observed in an acute oral administration test in rats (OECD TG401; GLP) (BUA Report 255 (2006)), and test doses (1000, 1250, 1580 mg/kg) correspond to Category 2 in Guidance values, it was classified in Category 2 (nervous system). Besides, it corresponds to "Not classified" in dermal administration because a dermal administration test in rats given 2000 mg/kg reported only an unkempt coat in 1 animal but no other abnormal findings including in necropsy finding (BUA Report 255 (2006)). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | Necrosis in kidney and liver and adverse effects on the central nervous system were reported in a repeated dose test in which rats were given twice a day for 30 days (50, 100, 300 mg/kg bw), but the classification is not possible due to lack of data from an unknown administration route. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Not classified | - | - | - | From EC50s above 100 mg/L in acute toxicity tests for algae and crustacea (IUCLID, 2000; BUA, 2006), it was classified as "Not classified." |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - |
If chronic toxicity data are used, then it is classified as "Not classified" due to lack of rapid degradability (a degradation rate by BOD: 4, 5, 5% (the existing chemicals survey program, 2004)), and 72-hour NOEC = 100 mg/L for algae (Scenedesmus subspicatus) (IUCLID, 2000). If acute toxicity data are used for a trophic level for which chronic toxicity data are lacking, then it is classified as "Not classified" due to corresponding to "Not classified" in acute toxicity for crustacea (IUCLID, 2000), and not water-insoluble (water solubility = 524500 mg/L, PHYSPROP Database 2009). From the above, it was classified as "Not classified." |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/11/16 Addition of Rationale for the classification |