GHS Classification Result

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GENERAL INFORMATION

Item Information
CAS number 13517-24-3
Chemical name Sodium metasilicate nonahydrate
Substance ID 23A5161
Fiscal year of classification conducted FY2011
Classifier(s) (Ministries) Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
New/Revised New
Download in Excel format Excel file

REFERENCE INFORMATION

Item Information
Guidance used for classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition)
Definitions / Abbreviations (Excel file) Definitions / Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Explosives Not applicable - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - "Solids" according to GHS definition.
3 Aerosols Not applicable - - - Not an aerosol product.
4 Oxidizing gases Not applicable - - - "Solids" according to GHS definition.
5 Gases under pressure Not applicable - - - "Solids" according to GHS definition.
6 Flammable liquids Not applicable - - - "Solids" according to GHS definition.
7 Flammable solids Not classified - - - From the information that it is "Not combustible" (PIM 500 (1997)); (ICSC (J) (2004)), it was classified as "Not classified."
8 Self-reactive substances and mixtures Not applicable - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - "Solids" according to GHS definition.
10 Pyrophoric solids Not classified - - - From the information that it is "Not combustible" (PIM 500 (1997)); (ICSC (J) (2004)), it was classified as "Not classified."
11 Self-heating substances and mixtures Not classified - - - From the information that it is "Not combustible" (PIM 500 (1997)); (ICSC (J) (2004)), it was classified as "Not classified."
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - It contains a metal (Na) and a semimetal (Si), but it is conceivable that it does not react vigorously with water from data on the water solubility as "VERY SOLUBLE" (HSDB (2003)).
13 Oxidizing liquids Not applicable - - - "Solids" according to GHS definition.
14 Oxidizing solids Classification not possible - - - An inorganic compound does not contain halogen but contains oxygen which is chemically bonded to elements other than carbon or hydrogen, but the classification is not possible due to no data.
15 Organic peroxides Not applicable - - - It is an inorganic compound.
16 Corrosive to metals Classification not possible - - - The classification is not possible because a solid with a melting point of 55 degrees C or lower has no data.

HEALTH HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - From an LC50 value of an anhydrate for rats which was converted from 1152 to 1349 mg/kg into 2682 to 3140 mg/kg in molecular weight conversion (SIDS (2004)), it was classified as "Not classified" in JIS Classification (Category 5 in UN GHS classification).
Besides, refer to an anhydrate of this substance (CAS: 6834-92-0) and a pentahydrate of this substance (CAS: 10213-79-3) for health hazards.
1 Acute toxicity (Dermal) Classification not possible - - - No data.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - "Solids" according to GHS definition.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - No data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - No data.
2 Skin corrosion/irritation Category 1

Danger
H314
P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
From erythema and edema accompanied by necrosis lasted until day 5 and a primary dermal irritation index (PDII) of 8 which was assessed as corrosive in a semi-occlusive test applied 0.5g this substance moistened by water to rabbit skin for 24 hours (OECD TG404, GLP) (SIDS (2004)), it was classified in Category 1.
On the other hand, erythema and edema were not observed when the dry powder of this substance was applied (SIDS (2004)).
Besides, the pH of a 1% solution is 12 to 13 at 20 degrees C (IUCLID (2000)).
And an anhydrate is classified in R34 in EU classification (EC-JRC (ESIS) (Access on Nov. 2011)).
3 Serious eye damage/eye irritation Category 1

Danger
H318
P305+P351+P338
P280
P310
From "corrosive" as a result of an in vitro test applied to rabbit eyes (GLP compliance), pH 12 to 13 of a 1% solution at 20 degrees C (IUCLID (2000)), and "Category 1 (corrosive)" classification in skin corrosion/irritation, it was classified in Category 1.
4 Respiratory sensitization Classification not possible - - - No data.
4 Skin sensitization Classification not possible - - - Lack of data.
Besides, a negative result in an LLMA test (OECD TG429) on an anhydrate in mice, and contact urticaria in a human in a case study and formation of ulcer and wheal in the same human in a patch test (30 control subjects showed negatives) (SIDS (2004)) were reported.
But details are unknown.
5 Germ cell mutagenicity Not classified - - - On the basis that a chromosomal aberration test using mouse bone marrow cells after oral administration of an anhydrate resulted in a negative (in vivo somatic cell mutagenicity test) (SIDS (2004)), it was classified as "Not classified."
Besides, a negative result on an anhydrate was reported in an Ames test as an in vitro test (SIDS (2004)).
6 Carcinogenicity Classification not possible - - - Lack of data.
Besides, it is reported that significant effects were not observed in a drinking water administration test on an anhydrate in rats shortened to 14 months from 24 months as planned due to high mortality in all groups (SIDS (2004)), and carcinogenicity was not observed in another 2-year exposure test (IUCLID (2000)).
7 Reproductive toxicity Classification not possible - - - Lack of data.
Besides, no effects on parameters such as an implantation number, litter size, fertility index, numbers of live/dead fetuses, fetal body weights nor increased malformations of inner organs and the skeleton were reported in observations of fetuses at the end of pregnancy and neonates after deliveries in oral administration of an anhydrate during pregnancy including an organogenetic period to mice (SIDS (2004)).
But there are no data on effects on sexual function and fertility in parent animals.
8 Specific target organ toxicity - Single exposure Category 2 (nervous system)

Warning
H371
P309+P311
P260
P264
P270
P405
P501
Lethargy, increased breathing frequency, platycoria, and cramps in a single oral administration test in rat (doses: males 538 to 2000 mg/kg, females 910 to 2600 mg/kg) and signs including lethargy, no reaction to external stimuli, hanging eyelids, paralysis of hind limbs, clonic/tonic cramps, cyanosis, and respiratory paralysis in a single oral administration test in mice (doses: males 500 to 1921 mg/kg, females 500 to 1372 mg/kg) (both SIDS (2004)) were reported as data on an anhydrate.
Because doses converted to a nonahydrate by molecular weight conversion of the above nervous signs range to doses of a range of Category 2 in Guidance values ("1252 mg/kg or higher" or "1164 mg/kg or higher" respectively), it was classified in Category 2 (nervous system).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - A 26-day diet administration test using this substance in rats reported no adverse effects except tooth pigmentation, hair loss, seborrhea, and loss of tonicity (SIDS (2004)), but it is commented that the test is not a toxicity test due to the unsuitable test system having insufficient test items (SIDS (2004)).
Because the doses converted to a nonahydrate by molecular weight conversion from the reported data on an anhydrate, NOAEL of 227 to 237 mg/kg/day in a 3-month drinking water administration test in rats (SIDS (2004)), NOAEL of 792 mg/kg/day in a 2-year dirnking water administration test in rats (IUCLID (2000)), and NOAEL of 260 to 284 mg/kg/day in a 3-month drinking water administration test in mice (SIDS (2004)), exceeded the upper limit of Category 2 in Guidance values, it corresponds to "Not classified" in an oral route.
But it was classified as "Classification not possible" due to no information in other routes.
10 Aspiration hazard Classification not possible - - - No data.

ENVIRONMENTAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - No data.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - No data.
12 Hazardous to the ozone layer Classification not possible - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTES:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
   and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.



Updated date:
2016/11/16 Addition of Rationale for the classification

List of GHS Classification Results