Item | Information |
---|---|
CAS number | 78-88-6 |
Chemical name | 2,3-Dichloropropene |
Substance ID | 23A5164 |
Fiscal year of classification conducted | FY2011 |
Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
New/Revised | New |
Download in Excel format | Excel file |
Item | Information |
---|---|
Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition) |
Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | "Liquids" according to GHS definition. |
3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
6 | Flammable liquids | Category 2 |
H225 |
P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
A flash point of 15 degrees C [closed-cup] (HSDB (2003)) which is < 23 degrees C, and an initial boiling point of 94 degrees C (Howard (1997)) which is > 35 degrees C, correspond to Category 2. | |
7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
8 | Self-reactive substances and mixtures | Type G | - | - | - | Because it is conceivable that it does not correspond to a higher self-reactive property from class 3PGII in UNRTDG (UN2047) although it contains a chemical group associated with a self-reactive property (unsaturated bond), it was classified in Type G. |
9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition temperature of 510 degrees C (GESTIS (Access on Nov. 2011)). |
10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound does not contain oxygen or fluorine but contains chlorine which is not chemically bonded to elements other than carbon or hydrogen. |
14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
16 | Corrosive to metals | Classification not possible | - | - | - |
The classification is not possible due to no data. Besides, there is the information that says "Unsuitable materials: steel, aluminum, light metals, rubber (GESTIS (Access on Nov. 2011))." |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
H302 |
P301+P312 P264 P270 P330 P501 |
From an LD50 value of 320 mg/kg for rats (HSDB (2003)), it was classified in Category 4. | |
1 | Acute toxicity (Dermal) | Category 4 |
H312 |
P302+P352 P280 P312 P322 P363 P501 |
From an LD50 value of 1580 mg/kg bw for rats (HSDB (2003)), it was classified in Category 4. | |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | "Liquids" according to GHS definition. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - |
Lack of data. Besides, details of a reported LC50 value of 3.1 mg/L/2h (2.2 mg/L/4h) for rats (RTECS (2006)) from List 3 are unknown. Besides, it was considered to be a test by a vapour because the LC50 value (3.1 mg/L) is lower than 90% of the saturated vapour pressure concentration (365.5 mg/L). |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | No data. |
2 | Skin corrosion/irritation | Category 2 |
H315 |
P302+P352 P332+P313 P264 P280 P321 P362 |
Because in addition to the information that exposure to the skin causes severe skin irritation with a marked inflammatory response of epidermis and underlying tissues (HSDB (2003)), Xi; R37/38 in EU Classification (EC-JRC (ESIS) (Access on Nov. 2011)) was taken into consideration, it was classified in Category 2. Besides, List 2 data reported that 24-hour open application of 10 mg to rabbit skin caused severe irritation (RTECS (2006)). |
|
3 | Serious eye damage/eye irritation | Category 2 |
H319 |
P305+P351+P338 P337+P313 P264 P280 |
From a grade of 5 on a scale of 1 to 10 (on a scale of 1 to 10 according to the degree of injury and most severe injuries rated 10) (HSDB (2003)) and a description of eye irritation caused by a vapour of this substance in human (HSDB (2003)), it was classified in Category 2. Besides, it is classified in Xi; R41 in EU classification (EC-JRC (ESIS) (Access on Nov. 2011)). |
|
4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
4 | Skin sensitization | Classification not possible | - | - | - | No data. |
5 | Germ cell mutagenicity | Not classified | - | - | - |
From a negative result in a chromosomal aberration test (in vivo somatic cell mutagenicity test) using bone marrow cells after intraperitoneal administration in mice (NTP DB 313269 (Access on Nov. 2011)), it was classified as "Not classified." Besides, a sister chromatid exchange test (in vivo somatic cell genotoxicity test) using bone marrow cells after intraperitoneal administration in mice reported a negative. On the other hand, both an Ames test and a chromosomal aberration test using CHO cells reported positive results as in vitro tests (NTP DB (Access on Nov. 2011)). |
6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation, Narcotic effects) |
H335 H336 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
Gasping, refusal to breathe, coughing, pain, respiratory distress, irritation to upper respiratory mucosa immediately after exposure in a high concentration, and irritation to the respiratory system in a low concentration are described as signs caused by inhalation exposure in humans. (HSDB (2003)) And Xi; R37/38 in EU Classification was taken into consideration. Therefore, it was classified in Category 3 (respiratory tract irritation). Furthermore, from the information that inhalation or oral exposure causes central nervous system depression, malaise, and headache, and inhalation of a high concentration may cause coma (HSDB (2003)), it was classified in Category 3 (narcotic effects). |
|
9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - |
No data. Besides, individual data on each test item indicated in a 13-week inhalation exposure test in rats and mice (NTP DB 313269 (Access on Nov. 2011)) are not used for classification because they are not obtained as assessed reports. |
10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible | - | - | - | No data. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible | - | - | - | No data. |
12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
2016/11/16 Addition of Rationale for the classification |