GHS Classification Result

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GENERAL INFORMATION

Item Information
CAS number 78-88-6
Chemical name 2,3-Dichloropropene
Substance ID 23A5164
Fiscal year of classification conducted FY2011
Classifier(s) (Ministries) Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
New/Revised New
Download in Excel format Excel file

REFERENCE INFORMATION

Item Information
Guidance used for classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition)
Definitions / Abbreviations (Excel file) Definitions / Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Explosives Not applicable - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - "Liquids" according to GHS definition.
3 Aerosols Not applicable - - - Not an aerosol product.
4 Oxidizing gases Not applicable - - - "Liquids" according to GHS definition.
5 Gases under pressure Not applicable - - - "Liquids" according to GHS definition.
6 Flammable liquids Category 2

Danger
H225
P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
A flash point of 15 degrees C [closed-cup] (HSDB (2003)) which is < 23 degrees C, and an initial boiling point of 94 degrees C (Howard (1997)) which is > 35 degrees C, correspond to Category 2.
7 Flammable solids Not applicable - - - "Liquids" according to GHS definition.
8 Self-reactive substances and mixtures Type G - - - Because it is conceivable that it does not correspond to a higher self-reactive property from class 3PGII in UNRTDG (UN2047) although it contains a chemical group associated with a self-reactive property (unsaturated bond), it was classified in Type G.
9 Pyrophoric liquids Not classified - - - It is conceivable that it does not ignite at normal temperatures from an ignition temperature of 510 degrees C (GESTIS (Access on Nov. 2011)).
10 Pyrophoric solids Not applicable - - - "Liquids" according to GHS definition.
11 Self-heating substances and mixtures Classification not possible - - - No established test method suitable for liquid substances.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - An organic compound does not contain oxygen or fluorine but contains chlorine which is not chemically bonded to elements other than carbon or hydrogen.
14 Oxidizing solids Not applicable - - - "Liquids" according to GHS definition.
15 Organic peroxides Not applicable - - - An organic compound that does not contain -O-O- structure.
16 Corrosive to metals Classification not possible - - - The classification is not possible due to no data.
Besides, there is the information that says "Unsuitable materials: steel, aluminum, light metals, rubber (GESTIS (Access on Nov. 2011))."

HEALTH HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Acute toxicity (Oral) Category 4

Warning
H302
P301+P312
P264
P270
P330
P501
From an LD50 value of 320 mg/kg for rats (HSDB (2003)), it was classified in Category 4.
1 Acute toxicity (Dermal) Category 4

Warning
H312
P302+P352
P280
P312
P322
P363
P501
From an LD50 value of 1580 mg/kg bw for rats (HSDB (2003)), it was classified in Category 4.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - "Liquids" according to GHS definition.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - Lack of data.
Besides, details of a reported LC50 value of 3.1 mg/L/2h (2.2 mg/L/4h) for rats (RTECS (2006)) from List 3 are unknown.
Besides, it was considered to be a test by a vapour because the LC50 value (3.1 mg/L) is lower than 90% of the saturated vapour pressure concentration (365.5 mg/L).
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - No data.
2 Skin corrosion/irritation Category 2

Warning
H315
P302+P352
P332+P313
P264
P280
P321
P362
Because in addition to the information that exposure to the skin causes severe skin irritation with a marked inflammatory response of epidermis and underlying tissues (HSDB (2003)), Xi; R37/38 in EU Classification (EC-JRC (ESIS) (Access on Nov. 2011)) was taken into consideration, it was classified in Category 2.
Besides, List 2 data reported that 24-hour open application of 10 mg to rabbit skin caused severe irritation (RTECS (2006)).
3 Serious eye damage/eye irritation Category 2

Warning
H319
P305+P351+P338
P337+P313
P264
P280
From a grade of 5 on a scale of 1 to 10 (on a scale of 1 to 10 according to the degree of injury and most severe injuries rated 10) (HSDB (2003)) and a description of eye irritation caused by a vapour of this substance in human (HSDB (2003)), it was classified in Category 2.
Besides, it is classified in Xi; R41 in EU classification (EC-JRC (ESIS) (Access on Nov. 2011)).
4 Respiratory sensitization Classification not possible - - - No data.
4 Skin sensitization Classification not possible - - - No data.
5 Germ cell mutagenicity Not classified - - - From a negative result in a chromosomal aberration test (in vivo somatic cell mutagenicity test) using bone marrow cells after intraperitoneal administration in mice (NTP DB 313269 (Access on Nov. 2011)), it was classified as "Not classified."
Besides, a sister chromatid exchange test (in vivo somatic cell genotoxicity test) using bone marrow cells after intraperitoneal administration in mice reported a negative.
On the other hand, both an Ames test and a chromosomal aberration test using CHO cells reported positive results as in vitro tests (NTP DB (Access on Nov. 2011)).
6 Carcinogenicity Classification not possible - - - No data.
7 Reproductive toxicity Classification not possible - - - No data.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation, Narcotic effects)

Warning
H335
H336
P304+P340
P403+P233
P261
P271
P312
P405
P501
Gasping, refusal to breathe, coughing, pain, respiratory distress, irritation to upper respiratory mucosa immediately after exposure in a high concentration, and irritation to the respiratory system in a low concentration are described as signs caused by inhalation exposure in humans. (HSDB (2003)) And Xi; R37/38 in EU Classification was taken into consideration. Therefore, it was classified in Category 3 (respiratory tract irritation).
Furthermore, from the information that inhalation or oral exposure causes central nervous system depression, malaise, and headache, and inhalation of a high concentration may cause coma (HSDB (2003)), it was classified in Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - No data.
Besides, individual data on each test item indicated in a 13-week inhalation exposure test in rats and mice (NTP DB 313269 (Access on Nov. 2011)) are not used for classification because they are not obtained as assessed reports.
10 Aspiration hazard Classification not possible - - - No data.

ENVIRONMENTAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - No data.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - No data.
12 Hazardous to the ozone layer Classification not possible - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTES:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
   and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.



Updated date:
2016/11/16 Addition of Rationale for the classification

List of GHS Classification Results