GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 105-57-7 |
| Chemical name | 1,1-Diethoxyethane |
| Substance ID | 23A5166 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Category 2 |  |
H225 |
P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
A flash point of -21 degrees C [closed-cup] (HSDB) which is < 23 degrees C, and a boiling point of 102.7 degrees C (HSDB) which is > 35 degrees C, correspond to Category 2. Besides, it is classified in class 3PGII in UNRTDG (UN1088). |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an autoignition temperature of 230 degrees C (HSDB). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound does not contain fluorine or chlorine but contains oxygen which is not chemically bonded to elements other than carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | From an LD50 value of 4600 mg/kg for rats (JECFA Monograph 48 (2002)), it was classified as "Not classified" in JIS classification (corresponding to Category 5 in UN GHS classification). |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | From a reported LD50 value of 10 g/kg for rabbits (HSDB (2003)), it was classified as "Not classified." |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Not classified | - | - | - |
From an LC50 value of 18000 ppm/7h [converted to a 4-hour equivalent value: 23814 ppm/4h] for mice (PATTY (5th, 2001)), it was classified as "Not classified." Besides, a reference value of gasses was applied because the test concentration is lower than 90 % of the saturated vapour pressure concentration. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Not classified | - | - | - |
From Xi; R36/38 in EU Classification (EC-JRC (ESIS) (Access on Nov. 2011)) in addition to "Mild" reported in a test applied 500 mg of this substance to rabbit skin for 24 hours (PATTY (5th, 2001)), it was classified as "Not classified" in JIS classification (corresponding to Category 3 in UN GHS classification). Besides, irritation was not reported in a 48-hour occlusive application test of this substance at 10% in petrolatum to human subjects. (HSDB (2003)) |
| 3 | Serious eye damage/eye irritation | Category 2B | No pictogram |
H320 |
P305+P351+P338 P337+P313 P264 |
From Xi; R36/38 in EU Classification (EC-JRC (ESIS) Access on Nov, 2011) in addition to reported "slight" irritation to rabbit eyes (HSDB (2003)), it was classified in Category 2B. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | No data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, an Ames test reported a positive result as an in vitro test (NTP DB (2007)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Narcotic effects, Respiratory tract irritation） |  |
H335 H336 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
Anesthesia was reported in a test exposed up to an extremely high concentration of 153000 ppm to guinea pigs and mice. (PATTY (5th, 2001)) On the other hand, there is the information that this substance has a narcotic action (PATTY (5th, 2001)). From the above, it was classified in Category 3 (narcotic effects). Furthermore, on the basis that a definite evidence of irritation including squinting, sneezing, and nasal discharge, and respiratory tract irritation noted at a low dose were reported in the above guinea pig test (PATTY (5th, 2001)), it was classified in Category 3 (respiratory tract irritation). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - |
Lack of data. Besides, only minor irritation was observed although the lack of coordination at a concentration of 11000 ppm was shown in an inhalation test exposed for 7 hours/time for 15 times to mice. And in a 22-day exposure of 14000 ppm, six out of 50 animals died, and the strong evidence of irritation and a narcotic action was observed. (PATTY (5th, 2001)) But other specific systemic effects in repeated exposure were not described. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | No data. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/11/16 Addition of Rationale for the classification |