GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 598-56-1 |
| Chemical name | N,N-Dimethylethylamine |
| Substance ID | 23A5170 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Category 2 |  |
H225 |
P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
A flash point of -45.5 degrees C [closed cup] (IUCLID (2000)) which is < 23 degrees C, and an initial boiling point of 36.5 degrees C (Howard (1997)) which is > 35 degrees C, correspond to Category 2. |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition point of 190 degrees C (IUCLID (2000)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound that does not contain oxygen, fluorine, or chlorine. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No established test method suitable for a liquid with a low boiling point. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |  |
H302 |
P301+P312 P264 P270 P330 P501 |
From an LD50 value of 606 mg/kg for rats (IUCLID (2000)), it was classified in Category 4. |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | From an LD50 value of >2000 mg/kg and no deaths at 2000 mg/kg in rats as a result [OECD TG 402, GLP] (IUCLID (2000)), it was classified as "Not classified." |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 1 |  |
H330 |
P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Because an LC50 value was regarded as within a range between 80 and 140 ppm (converted to a 4-hour equivalent: 40 to 70 ppm) from no deaths at 80 ppm and all deaths at 140 ppm as a result of a 1-hour exposure test using 4 rats in a group (IUCLID (2000)), it was classified in Category 1. Besides, a result from a reported LC50 value of 2.3 to 15.4 mg/L/1h for rats (converted to a 4-hour equivalent: 384 to 2574 ppm/4h) (IUCLID (2000)) corresponds to Category 2 to 4, Furthermore, a reference value of gasses as vapour with hardly included mist was applied because the test concentration is lower than 90 % of the saturated vapour pressure concentration (1386 mg/L = 463157 ppm). Besides, it is classified in Xn; R20/22 in EU classification (EC-JRC (ESIS) (Access on June. 2011)). |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Category 1 |  |
H314 |
P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
Because a test using rabbits resulted in corrosive (IUCLID (2000)) and pH is 12 (20 degrees C, 50 g/L) (GESTIS (Access on No. 2011)), it was classified in Category 1. Besides, it is classified in C; R34 in EU classification (EC-JRC (ESIS) (Access on Nov. 2011)). |
| 3 | Serious eye damage/eye irritation | Category 1 | |
H318 |
P305+P351+P338 P280 P310 |
Because a test using rabbits resulted in irritating (IUCLID (2000)) and pH is 12 (20 degrees C, 50 g/L) (GESTIS (Access on No. 2011)), it was classified in Category 1. Besides, an 8-hour inhalation exposure test at 40 to 50 mg/m3 to 4 human volunteers reported irritation to the ocular mucous membrane, visual disturbances (bleary eyes), and slight edema of corneal epithelium. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | A maximization test in guinea pigs (OECD TG406, GLP) reported it was not sensitizing (IUCLID (2000)), but it was classified as "Classification not possible" due to List 2 data with no positive rate and no test details. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, both an Ames test (OECD TG471, GLP) and a chromosomal aberration test using human lymphocytes (Directive 84/449/EEC, B.10: GLP) reported negatives as in vitro tests (IUCLID (2000)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
| 8 | Specific target organ toxicity - Single exposure | Category 2 (systemic toxicity) |  |
H371 |
P309+P311 P260 P264 P270 P405 P501 |
There is the information that emergency room records indicated systemic effects such as nausea, dizziness, fainting, oppressive feeling or pain in the chest, abdominal cramps, headache, and increased heart rate in human exposure to this substance (HSDB (2008)). But it was classified in Category 2 (systemic toxicity) due to List 2 information and not possible to specify target organs. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | No data. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 2 |
H401 |
P273 P501 |
It was classified in Category 2 from 96-hour EC50 = 7.6 mg/L for algae (Scenedesmus subspicatus) (IUCLID (2000)). | |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - |
Reliable chronic toxicity data are not obtained. It was classified as "Not classified" due to rapid degradability (DOC after 28 days by ISO7827: 97 %) (IUCLID (2000)) and no bioaccumulation estimate (LogPow = 0.7 (PHYSPROP Database, 2009)) despite acute toxicity Category 2. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/10/31 Addition of Rationale for the classification |