GHS Classification Result

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GENERAL INFORMATION

Item Information
CAS number 6317-18-6
Chemical name Methylene bis(thiocyanate)
Substance ID 23A5172
Fiscal year of classification conducted FY2011
Classifier(s) (Ministries) Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
New/Revised New
Download in Excel format Excel file

REFERENCE INFORMATION

Item Information
Guidance used for classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition)
Definitions / Abbreviations (Excel file) Definitions / Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Explosives Not applicable - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - "Solids" according to GHS definition.
3 Aerosols Not applicable - - - Not an aerosol product.
4 Oxidizing gases Not applicable - - - "Solids" according to GHS definition.
5 Gases under pressure Not applicable - - - "Solids" according to GHS definition.
6 Flammable liquids Not applicable - - - "Solids" according to GHS definition.
7 Flammable solids Classification not possible - - - No data.
8 Self-reactive substances and mixtures Not applicable - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - "Solids" according to GHS definition.
10 Pyrophoric solids Classification not possible - - - No data.
11 Self-heating substances and mixtures Classification not possible - - - No established test method suitable for solid substances with a melting point of 140 degrees C or lower.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - "Solids" according to GHS definition.
14 Oxidizing solids Not applicable - - - An organic compound does not contain oxygen, fluorine, or chlorine.
15 Organic peroxides Not applicable - - - An organic compound that does not contain -O-O- structure.
16 Corrosive to metals Classification not possible - - - No established test method suitable for solid substances.

HEALTH HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Acute toxicity (Oral) Category 3

Danger
H301
P301+P310
P264
P270
P321
P330
P405
P501
All of 3 LD50 values for rats [55 mg/kg bw (NTP TOX 32 (1993)), 84.9 mg/kg (males), 68.3 mg/kg (females) (EPA RED (1997))] correspond to Category 3.
Besides, it is classified in T; R25 in EU classification (EC-JRC (ESIS) (Access on Nov. 2011)).
1 Acute toxicity (Dermal) Not classified - - - From an LD50 value of >2000 mg/kg for rats (EPA RED (1997)), it was classified as "Not classified" in JIS classification (Category 5 or "Not classified" in UN GHS classification).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - "Solids" according to GHS definition.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - No data.
1 Acute toxicity (Inhalation: Dusts and mists) Category 1

Danger
H330
P304+P340
P403+P233
P260
P271
P284
P310
P320
P405
P501
On the basis that an LC50 value was 0.0077 mg/L/4h for rats (EPA RED (1997)), it was classified in Category 1.
Besides, issues of the test method were pointed out such as a size of particles and a difference between a nominal dose and a measured concentration.
This data was used for the classification because it was finally judged to have potent toxicity (EPA REC (1997)).
2 Skin corrosion/irritation Category 2

Warning
H315
P302+P352
P332+P313
P264
P280
P321
P362
On the basis that a dermal irritation test (Draize method) reported a primary irritation index (PII) of 2<=PII<=5 and assessed as a moderate to severe dermal irritant (EPA RED (1997)), it was classified in Category 2.
Besides, it is classified in C; R34 in EU classification (EC-JRC (ESIS) (Access on Nov. 2011)).
3 Serious eye damage/eye irritation Category 1

Danger
H318
P305+P351+P338
P280
P310
All of six rabbits showed discomfort immediately after application of 50 mg and showed severe irritation signs accompanied by severe erythema (necrosis), moderate edema, and copious discharge after 10 minutes.
On the basis that it was judged as corrosive from the unanimous response in all of 6 animals 1 hour after application (HSDB (2010)), it was classified in Category 1.
4 Respiratory sensitization Classification not possible - - - No data.
4 Skin sensitization Category 1

Warning
H317
P302+P352
P333+P313
P261
P272
P280
P321
P363
P501
A maximization test in guinea pigs on a 5% solution of antimicrobial agent Cytox3522 containing this substance reported highly sensitizing and a positive rate of 100% (20/20) in a challenge test conducted with a 0.1% solution of this substance (NTP TOX 32 (1993)).
From the report, it was classified in Category 1.
Besides, it is classified in R43 in EU classification (EC-JRC (ESIS) (Access on Nov. 2011)).
5 Germ cell mutagenicity Not classified - - - Both a micronucleus test using peripheral blood after oral administration in mice and a micronucleus test using bone marrow after intraperitoneal administration in mice (in vivo somatic cell mutagenicity test) reported negatives (NTP DB (Access on Nov. 2011), EPA RED (1997)).
From the above, it was classified as "Not classified."
Besides, as in vitro tests, a negative in an Ames test (NTP DB (1986), EPA RED (1997)), a positive in a chromosomal aberration test using CHO cells (EPA RED (1997)), and a positive in a mouse lymphoma test (EPA RED (1997)) were reported respectively.
6 Carcinogenicity Classification not possible - - - Because it was classified in Group D in EPA carcinogenicity assessment (EPA RED (1997)), it was classified as "Classification not possible."
Besides, a 78-week gavage oral administration test using mice reported a significant increase in alveolar adenomas in the lung in males.
And a 2-year gavage oral administration test using rats reported an increase in adrenal pheochromocytomas in males (a total of benign and malignant carcinomas, but not statistically significant) (EPA RED (1997)).
7 Reproductive toxicity Not classified - - - In an oral administration two-generation reproductive test in rats, signs of respiratory difficulty, piloerection, and abdominal swelling were observed. And deaths occurred at the highest dose. But adverse effects on reproductive parameters such as cprecoital interval, duration of gestation, gestation index, fertility index, and adverse effects on development parameters of the offspring such as a live pup number and survival index during lactation were not obsereved. (EPA RED (1997)
On the other hand, in oral administration developmental toxicity tests in rats and rabbits during an organogenetic or gestation period, maternal rats showed slight decreases in body weights and food consumption. And maternal rabbits showed signs such as respiratory difficulty, ataxia, a decrease in motor activity, loss of righting reflex, and tremors and deaths at the highest dose.
But neither effects on parameters such as gestation index, numbers of corpora lutea and implantations, and a percent of pre- and post-implantation loss nor signs of teratogenicity were observed in both species (EPA RED (1997)).
It was classified as "Not classified" because neither adverse effects on sexual function and fertility in parent animals nor adverse effects on the development of the offspring were found from the above.
8 Specific target organ toxicity - Single exposure Category 2 (systemic toxicity)

Warning
H371
P309+P311
P260
P264
P270
P405
P501
In an acute oral toxicity test in rats (doses: 50.1, 63.1, 79.4, 100, 126, 158 mg/kg), reduced appetite and activity, increasing weakness and prostration were observed in a 14-day observation period. And deaths occurred in groups of 50 mg/kg or higher 1 to 24 hours after dosing. (HSDB (2010))
Furthermore, in an acute dermal toxicity test in rabbits (doses: 158, 251, 398, 631, 1000 mg/kg), reduced appetite and activity, progressive weakness, and prostration were observed within 14 days after dosing. And deaths occurred in groups of 398 mg/kg or higher. (HSDB (2010))
It is difficult to specify target organs from data obtained in both routes. And the doses in both oral and dermal routes correspond to Category 1 in Guidance values.
But it was classified in Category 2 (systemic toxicity) due to List 2 data.
9 Specific target organ toxicity - Repeated exposure Category 1 (blood system)

Danger
H372
P260
P264
P270
P314
P501
In a 13-week oral administration test in rats (0, 1, 2, 4, 8, and 16 mg/kg/day), a sign of anemia, which was evidenced by decreases in red blood cell count, hemoglobin concentration, and hematocrit, was observed at 4 mg/kg or higher in males and at 8 mg/kg or higher in females. (NTP DB C61916 (1995))
In a 52-week oral administration test in dogs (0, 0.5, 2.0 or 5.0 mg/kg/day), marginally low red blood cell count, hemoglobin concentration, and hematocrit were observed in a 5 mg/kg/day group. (EPA RED (1997))
Because the above effects were at the doses corresponding to Category 1 in Guidance values, it was classified in Category 1 (blood system).
Besides, in a 13-week oral administration test in rats, effects on forestomach consisting of hyperplasia of squamous epithelium mucosa and hyperkeratosis were observed. But the findings of a stomach and respiratory tract were not used as bases for classification because respiratory changes were considered to be caused by direct contact with this highly irritant substance in forced oral dosage conducted by hands.
10 Aspiration hazard Classification not possible - - - No data.

ENVIRONMENTAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1

Warning
H400
P273
P391
P501
It was classified in Category 1 from 96-hour LC50 = 0.036 mg/L for crustacea (Mysidopsis bahia) (U.S. EPA: RED, 1996; AQUIRE, 2012).
11 Hazardous to the aquatic environment (Long-term) Category 1

Warning
H410
P273
P391
P501
If chronic toxicity data are used, then it is classified in Category 1 from non-rapidly degradable (a degradation rate by BOD: 0 % (the existing chemicals survey program, 1995)) and NOEC = 5.8 ppb for crustacea (Daphnia magna) (U.S. EPA: RED, 1996).
If acute toxicity data are used for trophic levels for which chronic toxicity data are lacking, then it is classified in Category 1 from non-rapidly degradable (a degradation rate by BOD: 0 % (the existing chemicals survey program, 1995)), 96-hour LC50 = 0.036 mg/L for crustacea (Mysidopsis bahia), and 96-hour LC50 = 0.089 mg/L for fish (both U.S. EPA: RED, 1996; AQUIRE, 2012).
From the above results, it was classified in Category 1.
12 Hazardous to the ozone layer Classification not possible - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTES:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
   and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.



Updated date:
2016/10/31 Addition of Rationale for the classification

List of GHS Classification Results