Item | Information |
---|---|
CAS RN | 95-13-6 |
Chemical Name | indene |
Substance ID | 23B5512 |
Classification year (FY) | FY2011 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 3 |
Warning |
H226 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Among flash points of 51 deg C [closed-cup] (GESTIS (Access on Aug. 2011)), 58 deg C [closed-cup] (MSDS (Sigma-Aldrich) (Access on Aug. 2011)), and 78.33 deg C [closed-cup] (ACGIH (2008)), lower flash points were adopted for a safety reason. Therefore, a flash point of this substance was judged to be >= 23 deg C and <= 60 deg C, and it was classified in Category 3. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 517 deg C (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Committee), an acute toxicity test by oral administration of indene to rats (2006)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | It was classified as "Not classified" in the Classification JIS (Category 5 in UN GHS classification or "Not classified") based on an LD50 value of > 2,000 mg/kg for rats (JECDB (2006)). |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | It was classified as "Not classified" based on an LC50 value of 14 mg/L/4 hours for rats (Netherlands assessment document (2002), corresponding to List 2). Besides, because the LC50 value is higher than the saturated vapour pressure concentration (6.88 mg/L), it was regarded as a test on mist. |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | It was classified as "Not classified" because it is reported that no local cutaneous toxicity developed from painting the shaved skin of rats one to eight times with 0.1 mL (ACGIH (2008)), guinea pigs were not affected by three applications of 0.5 mL (ACGIH (2008)), and this substance was not irritating to the skin of rats and guinea pigs (Netherlands assessment document (2002)). |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | No data available. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. Besides, it is described that there may be skin sensitization by this substance (HSDB (2009)). However, due to no data shown, classification is not possible. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, it was reported to be negative in both an Ames test and a chromosomal aberration test with cultured Chinese hamster cells (CHL/IU) (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Committee) (2006)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. |
8 | Specific target organ toxicity - Single exposure | Category 1 (liver, kidney), Category 3 (respiratory tract irritation) |
Danger Warning |
H370
H335 |
P308+P311
P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
Liver damage occurred after inhalation exposure of rats to 800-900 ppm for 4-12 hours or longer (converted 4-hour equivalent value: about 3.8-4.3 mg/L), longer exposure periods resulted in slightly fatty degeneration to severe necrosis (ACGIH (2008)), and also in mice, moderate to severe liver damage was reported after 12-hour inhalation exposure to approximately 400 ppm (converted 4-hour equivalent value: 3.3 mg/L) (ACGIH (2008)). Because focal necrosis was also seen as histological changes in the kidney in the inhalation exposure test above with rats, it was classified in Category 1 (liver, kidney). Furthermore, in another inhalation exposure test with rats, dyspnea, wheezing, rhinorrhea, and lacrimation were found at 630 ppm and 1,100 ppm (4-hour exposure). Therefore, it was classified in Category 3 (respiratory tract irritation). Besides, because exposure concentrations in the tests above were all lower than the saturated vapour pressure concentration, they were regarded as exposure to vapour. |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Data are lacking. Besides, in a test by 105-day inhalation exposure of rats to 3 mg/m3 (0.6 ppm), exposure-related elevated blood cholinesterase activity and inhibition of catalase are described, but it is mentioned that the test is considered inadequate for setting occupational limits due to defective test methods such as the lack of a control group (ACGIH (2008)). Furthermore, it is described that liver and kidney disorders were observed at 800-900 ppm (7-hour exposure per day) in a 6-day inhalation exposure test with rats (Netherlands assessment document (2002)), but it was not adopted due to a shorter exposure duration of 6 days. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Data are lacking. Besides, it is described that aspiration into the lungs can result in chemical pneumonitis, pulmonary edema, and hemorrhage in laboratory animals (ACGIH (2008)). |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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