GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 79-44-7
Chemical Name Dimethyl carbamyl chloride
Substance ID 23B5513
Classification year (FY) FY2011
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 4
-
Warning
H227 P370+P378
P403+P235
P210
P280
P501
It corresponds to Category 4 from a flash point of 82 deg C [closed-cup] (MSDS (Sigma-Aldrich) (2011)), which is > 60 deg C and <= 93 deg C.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 410 deg C (Hommel (1996)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - The substance is an organic compound containing oxygen and chlorine which are chemically bonded only to carbon.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
It was classified in Category 4 from an LD50 value of 1,170 mg/kg for rats (ACGIH (2007)).
1 Acute toxicity (Dermal) Classification not possible
-
-
- - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 2


Danger
H330 P304+P340
P403+P233
P260
P271
P284
P310
P320
P405
P501
It was classified in Category 2 based on an LC50 value for rats of 180 ppm/6 hours (= 220.5 ppm/4 hours) (HSDB (2009)). Besides, because the toxicity value (180 ppm) is lower than 90% of the saturated vapour pressure concentration (2,566 ppm), the reference value of gasses was applied.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - No data available.
2 Skin corrosion/irritation Category 2


Warning
H315 P302+P352
P332+P313
P362+P364
P264
P280
P321
It was classified in Category 2 by considering the report that it was mild to moderately irritating to the (eye and) skin of rabbits with changes produced being reversible within one week (ACGIH (2007)) as well as EU's classification as Xi; R38.
3 Serious eye damage/eye irritation Category 2B
-
Warning
H320 P305+P351+P338
P337+P313
P264
It was classified in Category 2B by considering the report that it was mild to moderately irritating to the eye (and skin) of rabbits with changes produced being reversible within one week (ACGIH (2007)) as well as EU's classification as Xi; R36.
4 Respiratory sensitization Classification not possible
-
-
- - No data available.
4 Skin sensitization Classification not possible
-
-
- - It is reported that this substance was not a sensitizer in a test with guinea pigs (ACGIH (2007)), but because there is no description of the test method, and it is unknown if it is a test method approved by OECD, it was classified as "Classification not possible."
5 Germ cell mutagenicity Category 2


Warning
H341 P308+P313
P201
P202
P280
P405
P501
It was classified in Category 2 because it was reported to be positive in multiple micronucleus tests with mouse erythrocytes or bone marrow (in vivo mutagenicity tests) (IARC 71 (1999), ACGIH (2007)). Besides, it was reported to be negative in a sister chromatid exchange test with bone marrow cells after intraperitoneal administration to mice (in vivo somatic cell genotoxicity test) (IARC 71 (1999)), and as for in vitro tests, Ames tests gave mostly positive results (NTP DB (1979), IARC 71 (1999)), and it was reported to be positive in a gene mutation test with mouse lymphoma and a chromosomal aberration test with CHO cells (NTP DB (1979)).
6 Carcinogenicity Category 1B


Danger
H350 P308+P313
P201
P202
P280
P405
P501
It was classified in Category 1B because it was classified in 2A by IARC, A2 by ACGIH, and 2A by the Japan Society For Occupational Health (JSOH). Besides, many reports indicate increased incidences of squamous cell carcinoma in the respiratory tract, including the nasal cavity, nasopharynx, larynx, and bronchus, in long-term inhalation exposure tests with rats (ACGIH (2007)). And in a life-long exposure test with hamsters, there is a report on occurrences of squamous cell carcinomas of the nasal cavity (50/99), which were not observed in the control group (IARC 71 (1999)). Furthermore, also after dermal administration, an increased incidence of tumors at the site of administration was reported in mice (IARC 71 (1999)).
7 Reproductive toxicity Classification not possible
-
-
- - No data available.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
It is reported that all rats exposed to a saturated atmosphere for either 1 or 2 hours died with damage to the mucous membrane of the nose, throat, and lungs (IARC 12 (1976), ACGIH (2007)). The converted 4-hour equivalent value from the saturated vapour pressure concentration (11.3 mg/L) was 5.7-8.0 mg/L, corresponding to Category 1. Therefore, it was classified in Category 1 (respiratory system).
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - Data are lacking. Besides, liver disturbances were observed after occupational exposure (IARC 71 (1999)). However, because it is a report on only one case, and details such as a causal relationship are unknown, the classification is not possible. Furthermore, in an animal test, hamsters exposed to 1 ppm for 30 days showed normal body weights and survival (ACGIH (2007)), but there are no further descriptions, and the details of results are unknown. Besides, after 30-day exposure of rats to 1 ppm or above (exposure time per day: unknown) followed by observation up to two years, laryngeal hyperplasia and squamous metaplasia at 1 ppm and 10 ppm and tracheal squamous metaplasia at 10 ppm were seen, which were considered to be precancerous lesions (ACGIH (2007)).
10 Aspiration hazard Classification not possible
-
-
- - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2
-
-
H401 P273
P501
It was classified in Category 2 from 96-hour EC50 = 6.2 mg/L for algae (Pseudokirchneriella subcapitata) (data on dimethylamine, a hydrolysate) (AQUIRE, 2012).
11 Hazardous to the aquatic environment (Long-term) Not classified
-
-
- - Reliable chronic toxicity data were not obtained. As for dimethylamine, a hydrolysate, although it is classified in Category 2 in acute toxicity, it is rapidly degradable (a 4-week degradation rate by BOD: 88% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1975)), and low bioaccumulation is estimated (log Kow = -0.38 (PHYSPROP Database, 2009)). Therefore, it was classified as "Not classified."
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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