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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	7705-07-9
Chemical Name	titanium trichloride
Substance ID	23B5515
Classification year (FY)	FY2011
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	- -	-	-	It is described that it is combustible (Hommel (1996)), but the classification is not possible due to no test data.
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Category 1	Danger	H250	P335+P334 P370+P378 P210 P222 P280 P422	It was classified in Category 1 because the dry powder is pyrophoric in the air (Merck (14th, 2006)), and it is classified in Division 4.2, PG I in UNRTDG (UN2441).
11	Self-heating substances and mixtures	Not applicable	- -	-	-	It was classified as a pyrophoric solid.
12	Substances and mixtures which, in contact with water, emit flammable gases	Classification not possible	- -	-	-	Although it contains a metal (Ti), classification is not possible due to lack of data. Besides, there is information that it decomposes with the release of very much heat on contact with humidity or water. The heat causes spontaneous ignition. At that time, hydrogen chloride gas and its aqueous solution (hydrochloric acid), as well as titanium peroxide vapor and titanium dioxide are produced (Hommel (1996)).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Not classified	- -	-	-	The substance contains halogen (Cl), which is chemically bonded to an element other than carbon or hydrogen. However, due to the description of a powerful reducing agent (Merck (14th, 2006)), it was classified as "Not classified."
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic compound.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available. Besides, there is information that under the presence of humidity, it is corrosive to most metals, and such attacked ones are unsuitable as a container (Hommel (1996)).

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	There is an LD50 value for rats of 4,300 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 8 (Ministry of the Environment, 2010)), but because details such as test methods are unknown, the classification is not possible. Besides, there is a report on 130 mg/kg (20% formulation (20% titanium trichloride solution in hydrochloric acid)), > 300 mg/kg (both, Evaluation of effect for the food safety (Food Safety Commission, 2003), Document for the Committee on Poisonous and Deleterious Substances, the Pharmaceutical Affairs and Food Sanitation Council, Ministry of Health, Labour and Welfare). Besides, this substance reacts with air and water to form corrosive hydrogen chloride (gas), titanium peroxide (vapour), and titanium dioxide (residue). Therefore, please also refer to health hazards for hydrogen chloride (CAS RN 7647-01-0) and titanium compounds (titanium dioxide (IV) (CAS RN 13463-67-7), etc.).
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Data are lacking. Besides, by using a 20% solution of this substance in hydrochloric acid (concentration of hydrochloric acid: 2-3%), an LD50 value for rats was reported to be > 2,000 mg/kg (a converted value equivalent to this substance: > 400 mg/kg) (Evaluation of effect for the food safety (Food Safety Commission, 2003), Document for the Committee on Poisonous and Deleterious Substances, the Pharmaceutical Affairs and Food Sanitation Council, Ministry of Health, Labour and Welfare).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	It was classified in Category 1 based on a report that a skin irritation/corrosion test was not conducted because extremely strong corrosivity was observed in an acute dermal toxicity test with rats in which a 20% solution of this substance in hydrochloric acid (concentration of hydrochloric acid: 2-3%) was used (Evaluation of effect for the food safety (Food Safety Commission, 2003), Document for the Committee on Poisonous and Deleterious Substances, the Pharmaceutical Affairs and Food Sanitation Council, Ministry of Health, Labour and Welfare).
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	This substance was classified in Category 1 for the eye because it was classified as corrosive to the skin in skin corrosion/irritation in this classification.
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo test data. Besides, as for an in vitro test, it is reported to be positive in an Ames test (Mutagenicity Test Data of Existing Chemical Substances based on the toxicity investigation system of the Industrial Safety and Health Law (1996)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Classification not possible	- -	-	-	Data are lacking. Besides, it is reported that when rats were orally dosed with 1/10 of LD50 on gestational days 1-3 and compared with the control group, the number of embryo cells on a gestational day 5 was significantly lower at 4-cell and 8-cell stages and significantly higher at a 2-cell stage (Environmental Risk Assessment for Chemical Substances vol. 8 (Ministry of the Environment, 2010)).
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data available. Besides, in contact with air, water vapor, or water, this substance reacts vigorously with the release of very much heat to form corrosive hydrogen chloride (gas) (Hommel (1996)). For hydrogen chloride, after inhalation exposure of humans, symptoms such as dyspnea, laryngitis, bronchitis, bronchoconstriction, and pneumonia, edema, inflammation, and necrosis of the upper respiratory tract, and pulmonary edema were reported (GHS classification for hydrogen chloride).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	No data available.
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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