GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 12202-17-4
Chemical Name Lead oxide sulfate (Pb4O3(SO4))
Substance ID 23B5534
Classification year (FY) FY2011
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition)
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition)
7 Flammable solids Not classified
-
-
- - It was classified as "Not classified" from the description of non-flammability (IUCLID (2000)).
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition)
10 Pyrophoric solids Not classified
-
-
- - It was classified as "Not classified" from the description of non-flammability (IUCLID (2000)).
11 Self-heating substances and mixtures Not classified
-
-
- - It was classified as "Not classified" from the description of non-flammability (IUCLID (2000)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- - The substance contains a metal (Pb), but from water solubility data of 0.01 g/L (IUCLID (2000)), it is estimated that it does not react vigorously with water.
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition)
14 Oxidizing solids Not classified
-
-
- - The substance is an inorganic compound containing oxygen, but from the information of no oxidizing properties (IUCLID (2000) information from CHEMSON Ltd. and Akros Chemicals), it was classified as "Not classified."
15 Organic peroxides Not applicable
-
-
- - It is an inorganic compound.
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- - It was classified as "Not classified" in the Classification JIS (Category 5 in UN GHS classification or "Not classified") based on an LD50 value of > 2,500 mg/kg for rats (IUCLID (2000)).
1 Acute toxicity (Dermal) Not classified
-
-
- - It was classified as "Not classified" based on an LD50 value of > 10,000 mg/kg for rats (IUCLID, 2000).
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - No data available.
2 Skin corrosion/irritation Classification not possible
-
-
- - No data available. Besides, as effects in humans, it is described that there are no data for the local effects of lead or inorganic lead compounds on the skin and mucous membranes (DFGMAK-Doc. 17 (2002)), and it may cause severe irritation or burns in the skin (HSDB (2010)).
3 Serious eye damage/eye irritation Classification not possible
-
-
- - No data available. Besides, as effects in humans, it is described that there are no data for the local effects of lead or inorganic lead compounds on the mucous membranes (DFGMAK-Doc. 17 (2002)), and it may cause severe irritation or burns in the eye (HSDB (2010)).
4 Respiratory sensitization Classification not possible
-
-
- - No data available.
4 Skin sensitization Classification not possible
-
-
- - No data available.
5 Germ cell mutagenicity Classification not possible
-
-
- - No data available. There are negative or positive results in chromosomal aberration tests with lymphocytes of workers exposed to lead, but it is described that most of the tests were inadequate, and the genotoxic potential of lead cannot be evaluated as a whole (DFGMAK-Doc. 17 (2002)). On the other hand, inorganic lead compounds were classified in 3A for germ cell mutagenicity in MAK/BAT (2010).
6 Carcinogenicity Category 1B


Danger
H350 P308+P313
P201
P202
P280
P405
P501
It was classified in Category 1B because IARC classified inorganic lead compounds in Group 2A for carcinogenicity (IARC 87 (2006)). Besides, the Japan Society For Occupational Health (JSOH) classified lead compounds in 2B (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2011)), and ACGIH classified inorganic lead compounds in A3 (ACGIH (2001)).
7 Reproductive toxicity Category 1A


Danger
H360 P308+P313
P201
P202
P280
P405
P501
There are no data for this substance, but it is described as effects of inorganic lead compounds in humans that in the form of case series and epidemiological studies, the risk of spontaneous abortion before the 20th week of gestation is increased by maternal exposure to high concentrations, and prenatal lead exposure is associated with an increased risk of minor malformations, low birth weight, and postnatal growth rate (IARC 87 (2006)). Therefore, it was classified in Category 1A. Besides, it is reported that reduced sperm counts and sperm volume, reduced sperm motility, and morphological changes were observed after occupational exposure, but a dose-response relationship between the level of lead exposure and these effects cannot be derived from the results of most of the studies, therefore, toxicity in sperms was unknown (DFGMAK-Doc. 17 (2002)).
8 Specific target organ toxicity - Single exposure Category 1 (kidney, nervous system, gastrointestinal system, haemal system)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
There are no data for this substance, but neurotoxic effects of lead were well recognized, both the peripheral and central nervous system are targets for lead, and it is reported that lead encephalopathy occurs in cases of acute symptomatic lead poisoning, and wrist drop and slowing of nerve conduction velocity were described in occupational exposure (IARC 87 (2006)). Therefore, it was classified in Category 1 (nervous system). Acute exposure to high concentrations of lead and lead compounds results in disturbances in proximal tubular function, and renal manifestations of acute lead poisoning are collectively presented as Fanconi syndrome (glycosuria, aminoaciduria, phosphaturia, etc.) (IARC 87 (2006)). Therefore, it was classified in Category 1 (kidney). Furthermore, it was classified in Category 1 (blood system) because it is described lead has been known to alter the blood system by inhibiting several enzymes involved in heme biosynthesis such as delta-aminolevulinic acid dehydratase, and microcytic or hypochromic anemia results from inhibition of heme synthesis and shortening of erythrocyte lifespan (ATSDR (2007)). Other than the above, it is described that colic is a consistent early symptom of occupationally exposed cases or individuals acutely exposed to high levels, accompanied by signs such as constipation, cramps, nausea, vomiting, anorexia, and weight loss (ATSDR (2007)). Therefore, it was classified in Category 1 (digestive system).
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney, cardiovascular system, nervous system, haemal system)


Danger
H372 P260
P264
P270
P314
P501
There are no data for this substance, but it is described that chronic exposure to high concentrations of lead and inorganic lead compounds results in irreversible changes in the kidney, including tubular atrophy, interstitial fibrosis, glomerular sclerosis, and ultimately chronic renal failure (IARC 87 (2006)). Therefore, it was classified in Category 1 (kidney). Also, it is reported that in an epidemiological survey in patients with lead poisoning, hemoglobin and hematocrit were significantly decreased compared to unexposed controls (ATSDR (2007)), and it is described that lead inhibits several enzymes involved in heme biosynthesis such as delta-aminolevulinic acid dehydratase, and microcytic or hypochromic anemia results from inhibition of heme synthesis and shortening of erythrocyte lifespan (ATSDR (2007)). Therefore, it was classified in Category 1 (blood system). On the other hand, there is a study that supported a relationship between chronic lead-poisoning and myocardial damage, in which workers with chronic lead-poisoning had electrocardiographic changed (ACGIH (2001)), and analyses of epidemiological survey data led to conclusions that lead absorption causes a significant increase in both systolic and diastolic blood pressure (ACGIH (2001)). Therefore, it was classified in Category 1 (cardiovascular system). Furthermore, it was classified in Category 1 (nervous system) because it is reported that decreased motor conduction velocities were found in workers with high blood lead concentrations (ACGIH (2001)), and Parkinsonian syndrome was observed in seven out of nine persons exposed to lead batteries for 30 years or longer (NICNAS (2007)).
10 Aspiration hazard Classification not possible
-
-
- - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- - No data available.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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