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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	1738-25-6
Chemical Name	3-(Dimethylamino)propanenitrile
Substance ID	24A6001
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P403+P235 P210 P280 P501	From a flash point of 64 deg C [closed-cup ] > 60 deg C and <= 93 deg C, it corresponds to Category 4.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with self-reactive properties (aminonitriles) in the molecule, but the classification is not possible due to no data.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 290 deg C (ECHA CHEM 2012).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	There are two LD50 values for rats (1,290 mg/kg (eChemPortal (ECHA CHEM (2012), corresponding to List 2)), 2,262 mg/kg (IUCLID (2000))), one corresponds to Category 4, and the other corresponds to "Not classified" in the Classification JIS. Therefore, it was classified in Category 4 by adopting a more hazardous category.
1	Acute toxicity (Dermal)	Category 4	Warning	H312	P302+P352 P362+P364 P280 P312 P321 P501	It was classified in Category 4 based on an LD50 value of 1,213 mg/kg for rabbits (eChemPortal (ECHA CHEM (2012))).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	It is reported that mortality was 1/12 when rats were given 8-hour exposure to 5.72 mg/L (vapour: converted 4-hour equivalent value: 8.09 mg/L) (eChemPortal (ECHA CHEM (2012))), but the category cannot be determined with the data alone. Therefore, it was classified as "Classification not possible."
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Not classified	- -	-	-	After a 20-hour occlusive application of 0.5 mL of undiluted this substance to the skin of two rabbits, erythema was seen in only one animal and fully disappeared within four days, there is no edema in both animals, and the average scores of evaluation at 24, 48, and 72 hours were 0.5 for erythema and 0 for edema (eChemPortal (ECHA CHEM (2012))). Therefore, it was classified as "Not classified." Besides, it is reported that also in another test with rabbits, the irritation score was minimum 1 on a scale from 1 to 10, and it was not irritating (IUCLID (2000)).
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	After the application of 50 microL of undiluted this substance to the eye of two rabbits, the average scores of evaluation at 24, 48, and 72 hours were 1.3 for the cornea, 0 for the iris, 1.3 for the conjunctiva, and 0 for chemosis, and effects on the cornea and conjunctiva fully disappeared within eight days (eChemPortal (ECHA CHEM (2012))). From the above, it was classified in Category 2B because the score for the cornea was above 1.
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, a negative result was reported in an Ames test (IUCLID (2000)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Classification not possible	- -	-	-	Data are lacking. It is reported that in a test in which two pregnant rats were given 17-day diet administration at a 0.3% concentration, there was no toxicity in maternal animals, fetotoxicity, or teratogenicity (eChemPortal (ECHA CHEM (2012))), but the test conditions were insufficient due to being a test with only one dose and using the small number (2) of animals, and the details are unknown.
8	Specific target organ toxicity - Single exposure	Category 2 (kidney, urinary bladder, central nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In a test in which rats were orally administered 175, 350, 700 mg/kg, only twice a day, a positive correlation was observed between urinary retention and the doses, and histological examination of the urinary bladder revealed marked submucosal and subserosal edema, severe capillary congestion, petechial hemorrhage, and multifocal perivascular inflammatory Iinfiltrates under the mucous membrane. In a visual and microscopic inspection of the kidney, hydronephrosis indicative of dilatation of the renal pelvis with blunting of the renal papilla was also found (eChemPortal (ECHA CHEM (2012))). Because the test doses above were within the guidance value range for Category 2, it was classified in Category 2 (kidney, urinary bladder). Furthermore, it was classified in Category 2 (central nervous system) because signs of convulsions (stretch/bend), tremor, tonic-clonic convulsions, apathy, and abdominal/lateral position were seen in an acute toxicity test with rats (doses: 860-3,990 mg/kg) (eChemPortal (ECHA CHEM (2012))).
9	Specific target organ toxicity - Repeated exposure	Category 1 (urinary bladder, nervous system)	Danger	H372	P260 P264 P270 P314 P501	Urinary dysfunction (urinary retention, hesitancy, decreased or intermittent flow, straining, bladder distension, etc.) was reported in workers handling this substance, and it is reported that in a follow-up survey on workers with bladder neuropathy caused by exposure to this substance, neurological abnormalities were observed in three out of 10 affected workers, one of them showed sensory-motor neuropathy, and urologic testing revealed persistent abnormalities in several workers (PATTY 2001). Furthermore, it is reported that sensory peripheral neuropathy was also seen in a few persons due to occupational exposure, and in one plant, a lot of workers showed central nervous system symptoms such as insomnia, irritability, and impaired intellectual function (HSDB (2003)). It was classified in Category 1 (urinary bladder, nervous system) based on the above knowledge in humans.
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	It was classified as "Not classified" because toxicity values are > 100 mg/L for all of the algae, crustacea, and fish (IUCLID, 2000).
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is not water-insoluble (water solubility: 1000000 mg/L, PHYSPROP Database, 2009), and it corresponds to "Not classified" in acute toxicity for algae, crustacea, and fish (IUCLID, 2000).
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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