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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	107-16-4
Chemical Name	Glycolonitrile
Substance ID	24A6003
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P403+P235 P210 P280 P501	There is information that commercial products are diluted with water for stabilization (ICSC (J) (2002)). A flash point is 69 deg C [closed-cup] for an aqueous solution containing 55% of glyconitrile (MSDS (Sigma-Aldrich) (2010)), and this value of > 60 deg C and <= 93 deg C corresponds to Category 4. Besides, there are data: a flash point of 56.1 deg C [unnkown] (Chemical Substances Safety Data Book (The Chemical Substances Safety Information Workshop) (1997)), and the value corresponds to Category 3, but it was not adopted due to unknown details.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	It was classified in Category 2 based on an LD50 value for rats of 0.016 g/kg bw for a 70% solution of this substance (RTECS (2000): the original article, American Industrial Hygiene Association Journal Vol. 23 (1962)).
1	Acute toxicity (Dermal)	Category 1	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	It was classified in Category 1 based on an LD50 value for rabbits of 0.005 g/kg bw for a 70% solution of this substance (RTECS (2000): the original article, American Industrial Hygiene Association Journal Vol. 23 (1962)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	After 8-hour exposure to 27 ppm in rats (converted 4-hour equivalent value = 38 ppm), 6/7 animals died (PATTY (5th, 2001)), and an LC50 value was estimated to be < 38 ppm. Therefore, it was classified in Category 1. Besides, because the test concentration was lower than 90% of the saturated vapour pressure concentration (267 ppmV), a reference value of gas was applied.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Data are lacking. Besides, as data from List 3, it is reported that there was mild irritation after the 24-hour application of 500 mg to the rabbit skin (RTECS (2000)), and it is described that direct contact with exposed skin gives no immediate sensation (HSDB (2002)), but the details are unknown in both.
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Data are lacking. Besides, it is described that it is an eye irritant (HSDB (2002)), but the details are unknown.
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, it was reported to be negative in an Ames test (NTP DB ID: 735832 (1984)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	In humans, it is reported that after dermal exposure (possibly accompanied by inhalation exposure) to a 70% solution of this substance, headache, dizziness, and unsteady gait were observed, also, vomiting, pale skin, bewilderedness, tachycardia, and arrhythmia were found (PATTY (5th, 2001)), and there were mainly signs of central nervous system depression (HSDB (2002)). Therefore, it was classified in Category 1 (central nervous system).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Data are lacking. Besides, it is described that doses of <= 92 mg/kg/day produced no observable effects in a 13-week oral administration test with female rats (PATTY (5th, 2001)), but the details are unknown. Therefore, the classification is not possible.
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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