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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	814-78-8
Chemical Name	Methyl isopropenyl ketone
Substance ID	24A6005
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 2 from a flash point of 9 deg C (closed-cup) (HSDB (2002)) <23 deg C, and an initial boiling point of 98 deg C (HSDB (2002)) >35 deg C.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with explosive properties (olefins) in the molecule. It has reactivity specific to alpha, beta-unsaturated ketones (Ullmanns (E) (6th, 2003)), and only the one stabilized with up to 1% of hydroquinone (UN-1246) can be transported (Weiss (2nd, 1986)). Stabilized products, which can be transported by contractors, are classified as Type G, but no data for classification are found on a pure substance.
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	It was classified in Category 3 based on an LD50 value of 180 mg/kg for rats (PATTY (5th, 2001)).
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	It was classified in Category 3 based on an LD50 value of 230 mg/kg for rabbits (PATTY (5th, 2001)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	From the result that 4-hour exposure to 125 ppm in six rats caused the death of five animals (PATTY (5th, 2001)), an LC50 value was estimated to be 125 ppm or less, corresponding to Category 1 or Category 2. Because the test concentration was close to the upper limit of reference values for Category 1, it was classified in Category 1 by putting weight on safety. Besides, because the test concentration (125 ppm) was lower than 90% of the saturated vapour pressure concentration (55263 ppm), a reference value of gas was applied.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It was classified in Category 2 because it is reported that it was moderately irritating in a test by occlusive application to the rabbit skin (PATTY (5th, 2001)).
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	It was classified in Category 1 because it is reported that it was severely irritating in a test by application to the rabbit eye (PATTY (5th, 2001)), and it is described that eye contact may result in severe damage, leading to a permanent impairment of vision in humans (HSDB (2002)).
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, a negative result is reported in an Ames test (PATTY (5th, 2001)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system, respiratory system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	It is reported that 4-hour inhalation exposure (vapour) to 125 ppm (0.43 mg/L) in rats caused cyanosis, five out of six animals died in convulsions, and delayed deaths were related to irritation of the respiratory system (PATTY (5th, 2001)). Because the test concentration corresponded to Category 1, it was classified in Category 1 (nervous system, respiratory system).
9	Specific target organ toxicity - Repeated exposure	Category 1 (kidney, respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	In a 140-day inhalation exposure test with rats (7 hours/day) (vapour), there is a report on death, nasal irritation, leukocytosis, and slight renal damage (increased kidney weight, slight tubular damage) at 15 ppm (0.052 mg/L) (converted 6-hour equivalent value: 0.056 mg/L) (PATTY (5th, 2001)), and in a 28-day inhalation exposure test with rats (7 hours/day) (vapour), death, marked nasal irritation, and severe effects on the lunge were observed at 30 ppm (0.103 mg/L) (converted guidance value: 0.035 mg/L) (PATTY (5th, 2001)). From the above, because both doses corresponded to the guidance values for Category 1, it was classified in Category 1 (kidney, respiratory system).
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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