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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	512-56-1
Chemical Name	Trimethyl phosphate
Substance ID	24A6014
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	- -	-	-	It was classified as "Not classified" from a flash point of 150 deg C [closed-cup] (MSDS (Sigma-Aldrich) (Access on May 2012)).
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	There is a metalloid (P) present in the molecule, but from information: water solubility of 500000 mg/L (HSDB (2003)) and "stable in water" (SIDS 1996), it is estimated that it does not react vigorously with water.
13	Oxidizing liquids	Classification not possible	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (P). However, the classification is not possible due to no data on oxidization.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified in Category 4 based on an LD50 value of 840 mg/kg for rats (SIDS (1996)).
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification) based on an LD50 value of 2830 mg/kg for rabbits (PATTY (5th, 2001)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It was classified in Category 2 because it is described that it is a strong irritant to the skin (HSDB (2003)), and skin irritation rated 4 on a scale from 1 to 10 in a test with rabbits (GESTIS (Access on May 2012)).
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	It was classified in Category 2B because it is described that it is a strong irritant to the eye (HSDB (2003)), and irritation rated 2 on a scale from 1 to 10 (10 being most severe) in a test with rabbits (HSDB (2003)).
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Category 1B	Danger	H340	P308+P313 P201 P202 P280 P405 P501	It was classified in Category 1B because positive results are reported in a dominant lethal test and a mutual translocation test by single intraperitoneal administration to male mice (doses: 1,000 mg/kg, 1,500 mg/kg) (in vivo heritable germ cell mutagenicity test), in which dose-dependent increases in early fetal deaths and sterility of male F1 offspring were induced (HSDB (2003)). Besides, a micronucleus test by intraperitoneal administration to mice (in vivo mutagenicity test) was positive (SIDS (1996)), and as for in vitro tests, it is reported that it was positive at 6,666, 10,000 microg/plate in TA100 in an Ames test and also positive at a high concentration of 5 mg/mL in a chromosomal aberration test with cultured Chinese hamster cells (CHO cells) (both NTP DB (1986)). On the other hand, it was reported to be negative in a chromosomal aberration test with cultured Chinese hamster cells (CHL cells) according to the latest guideline (OECD TG473, GLP) (JECDB (Access on May 2012)).
6	Carcinogenicity	Classification not possible	- -	-	-	In a carcinogenicity test by 2-year oral administration to 50 rats and mice of each sex, there was no evidence of carcinogenicity in female rats and male mice, but a significant increase in the incidence of adenocarcinoma in the uterus/endometrium in female mice and a significant increase in the incidence of fibroma in the subcutaneous tissue in male rats were observed (NTP TR81 (1978)). However, because the report alone constitutes only limited evidence of carcinogenicity, and there is no information in humans, it was classified as "Classification not possible."
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration to rats (OECD TG422, GLP), under the circumstances where neurological symptoms, mainly paralysis of the hindlimb, and histopathological findings of lesions in the renal papilla and tubular epithelium cells at 250 mg/kg/day, similar but milder toxicity (compared to 250 mg/kg/day) at 100 mg/kg/day, and lesions in the tubular epithelium cells also at 40 mg/kg were observed as general toxicity in parent animals, adverse effects on reproduction and development were observed including significant decreases in copulation rate at 250 mg/kg, fertility rate and implantation rate at 100 mg/kg, and a decrease in intrauterine survival of implanted embryos at 40 mg/kg (JECDB (Access on May 2012)). Therefore, it was classified in Category 2. Besides, it is reported that spermatozoa obtained from the epididymis of male rats after 30-day or 60-day oral administration at 250 mg/kg were all abnormal and lost germ cell activity, and the animals lacked mating ability (HSDB (2003)).
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	It is reported that after oral administration of a lethal dose to rats, guinea pigs, or rabbits, a rate and amplitude of respiration gradually decreased, and the animals showed general weakness, mild irritability, and fine tremors, followed by dyspnea, collapse, and death by respiratory failure (HSDB (2003)). On the other hand, it is described that weakness and paralysis are neurotoxic effects of this substance in human exposure (HSDB (2003)). Because the oral administration dose in the above corresponds to Category 2 by estimating from an LD50 value for rats (840 mg/kg), it was classified in Category 2 (nervous system).
9	Specific target organ toxicity - Repeated exposure	Category 2 (nervous system, kidney)	Warning	H373	P260 P314 P501	In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration to rats (OECD TG422, GLP), neurological symptoms, mainly paralysis of the hindlimb were observed at 250 mg/kg/day, which was an intoxicating dose that caused high lethality in males and slight lethality in females. At the dose of 250 mg/kg/day, toxicity was shown as histopathological findings, inducing lesions in the renal papilla and tubular epithelium cells, degeneration of nerve fiber in the spinal cord and peripheral nerves, and diffuse atrophy of skeletal muscle fiber, and at 100 mg/kg/day, similar but milder toxicity (compared to 250 mg/kg/day) was found. And lesions in the tubular epithelium cells were also seen at 40 mg/kg (JECDB (Access on May 2012)). From the above, main organs in which adverse effects were shown were the nervous system and kidney, and findings were at or above 40 mg/kg/day (converted guidance value: about 20 mg/kg/day) or at or above 100 mg/kg/day (converted guidance value: about 50 mg/kg/day), corresponding to the guidance value range for Category 2. Therefore, it was classified in Category 2 (nervous system, kidney).
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	It was classified as "Not classified" because acute toxicity is not reported at 100 mg/L for algae, crustacea, and fish (SIDS, 2005).
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	If chronic toxicity data are used, then it is classified as "Not classified" due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1984)), and 21-day NOEC = 520 mg/L for crustacea (Daphnia magna) (SIDS, 2005). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" because it is not water-insoluble (water solubility = 500000 mg/L, PHYSPROP Database (2009)), and it corresponds to "Not classified" in acute toxicity for fish (SIDS, 2005). From the above results, it was classified as "Not classified."
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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