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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	2530-87-2
Chemical Name	gamma-Chloropropyltrimethoxysilane
Substance ID	24A6015
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It corresponds to Category 3 from a flash point of 45 deg C [closed-cup] (SIDS (2006)) >= 23 deg C and <= 60 deg C. Besides, there are other data: 84 deg C (unknown), 57 deg C (unknown) (SIDS (2006)), but 45 deg C was adopted with safety in mind.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 220 deg C (GESTIS (Access on May 2012)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	There is a metalloid (Si) present in the molecule, but from data on water solubility: 650,000 mg/L (25 deg C) (SIDS (2006)), it is estimated that it does not react vigorously with water.
13	Oxidizing liquids	Classification not possible	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (Si). However, the classification is not possible due to no data.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" because it is reported that there were no dead animals after administration of 2,000 mg/kg to rats (OECD TG401; GLP), and an LD50 value was > 2,000 mg/kg bw (SIDS (2006)).
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" because it is reported that there were no dead animals after administration of 2,000 mg/kg to rats (OECD TG401; GLP), and an LD50 value was > 2,000 mg/kg (SIDS (2006)). Besides, as for rabbits, from an LD50 value of 3,595-3,991 mg/kg (SIDS (2006)), it would be "Not classified" in the Classification JIS (Category 5 in UN GHS classification).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Data are lacking. Besides, it is reported that there was no death after 6-hour exposure to the saturated vapour, but the category cannot be determined. Therefore, the classification is not possible.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It is reported that in a test by a 4-hour semi-occlusive application of 0.5 mL of the undiluted test substance to the skin of six rabbits (OECD TG404, GLP), erythema and edema were observed in three animals each 72 hours after the application, but these disappeared by day 17, the primary dermal irritation index (PII) was 3.23, and it was moderately irritating (SIDS (2006)). Therefore, it was classified in Category 2. Besides, it is reported that no irritation was found in another test by a 4-hour occlusive or semi-occlusive application of 0.5 mL of the undiluted test substance to the rabbit skin, and it was not irritating (SIDS (2006)).
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	In a test in which 0.1 mL of the undiluted test substance was applied to the rabbit eye (OECD TG405; GLP), one out of three animals showed only minimal conjunctival irritation, and it was judged to be not irritating. On the other hand, in another test in which 0.1 mL of the undiluted test substance was applied to the rabbit eye (in general conformance with OECD TG405 and GLP), slight erythema and edema with discharge were observed within 1 hour after the application but disappeared within 24 hours, and slight iritis was found within 4 hours in two out of six animals, but no corneal injury was seen, and it was judged to be slightly irritating (SIDS (2006)). It was classified in Category 2B as a more hazardous category based on data in the latter test.
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Not classified	- -	-	-	It was classified as "Not classified" because it was assessed to be not sensitizing in a skin sensitization test by a Buehler test with guinea pigs (OECD TG406, GLP) (SIDS (2006)).
5	Germ cell mutagenicity	Not classified	- -	-	-	It was classified as "Not classified" based on negative results in both a micronucleus test with bone marrow cells after intraperitoneal administration to mice (OECD TG474, GLP) and a micronucleus test with bone marrow cells after 90-day inhalation exposure in rats (SIDS (2006)) as in vivo somatic cell mutagenicity tests. Besides, as for in vitro tests, there is a report on positive results in both an Ames test and a mouse lymphoma test (SIDS (2006)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Classification not possible	- -	-	-	In a one-generation reproductive test with rats by inhalation exposure in males for 28 days from 14 days before mating and females from 14 days before mating throughout the mating and gestation period until 19 days after mating (OECD TG422, GLP), no general toxicity or reproductive toxicity was observed in parent animals even at the highest dose of 100 ppm (SIDS (2006)). However, because data are lacking on effects on the development of offspring including teratogenicity, it was classified as "Classification not possible."
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	An approximate lethal dose was 10,000 mg/kg in an acute oral administration test with rats, and lethargy and loss of muscle coordination were observed 30 minutes after administration of 5000-10000 mg/kg (SIDS (2006)). And symptoms such as abnormal gait, squatting, and staggering were found up to 6 hours after administration in a test with rats given single oral administration of 2,000 mg/kg (OECD TG401, GLP), but all animals appeared normal after 24 hours (SIDS (2006)). It was classified in Category 3 (narcotic effects) based on the above findings.
9	Specific target organ toxicity - Repeated exposure	Category 2 (urinary bladder)	Warning	H373	P260 P314 P501	In a 90-day repeated inhalation exposure test with rats (vapour, 0.004, 0.041, 0.814, 1.627 mg/L, 6 hours/day), an increased incidence of hyperplasia of the urinary bladder epithelium in males and females and an increased incidence and severity of alpha-2microglobulin (hyaline droplet nephropathy) in the kidney in males were observed at 100 ppm (0.814 mg/L) as exposure effects (SIDS (2006)). Because the exposure concentration (0.814 mg/L) corresponded to the guidance values for Category 2, it was classified in Category 2 (urinary bladder). On the other hand, alpha-2microglobulin nephropathy was not adopted for the rationale because it is a change specific to male rats and does not apply to humans. Besides, an increased incidence of hyperplasia of the urinary bladder epithelium was also found in another test by 28-day repeated inhalation exposure in rats (SIDS (2006)).
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	It was classified as "Not classified" because toxicity values are >100 mg/L for all of the algae, crustacea, and fish (SIDS, 2006).
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	If chronic toxicity data are used, then it is classified as "Not classified" due to rapid degradability (SIDS, 2006), and 72-hour NOEC = 70 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2006). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" because it is not water-insoluble (water solubility = 14600 mg/L, PHYSPROP Database 2009), and it corresponds to "Not classified" in acute toxicity for fish (SIDS, 2006). By drawing a comparison between the above results, it was classified as "Not classified."
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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