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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	115-95-7
Chemical Name	Linalyl acetate
Substance ID	24A6018
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P403+P235 P210 P280 P501	It corresponds to Category 4 from a flash point of 85 deg C [closed-cup] (ICSC (J) (2009)) > 60 deg C and <= 93 deg C.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Type G	- -	-	-	There is a chemical group associated with self-reactive properties (unsaturated bond) in the molecule, but it was judged that the substance is not self-reactive from the information of " Instability: 0" (NFPA (14th, 2010)).
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 225 deg C (ICSC (J) (2009)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" based on an LD50 value of 14,550 mg/kg for rats (SIDS (2002)).
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" based on an LD50 value of > 5,000 mg/kg for rabbits (USEPA/HPV (2001), corresponding to List 1).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Data are lacking. Besides, 90-minute exposure to a concentration of 2.74 mg/L caused reduced motor activity in mice, but no death was observed (SIDS (2002)). However, because the category cannot be determined with this information alone, the classification is not possible. Besides, because the test concentration (2.74 mg/L) was above the saturated vapour pressure concentration (1.17 mg/L), it was regarded as a test on a mist.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It was classified in Category 2 because, in a skin irritation test on which 0.5 mL of undiluted this substance was applied to three rabbits for 4 hours (OECD TG 404, GLP), clear erythema and minimal to slight edema were observed 1-3 days after the application, and skin irritation index (PII) was 3.67 (ECETOC TR 66 (1995)). Besides, as other knowledge, it was reported to be severely irritating in a skin irritation test in which 0.1 g of this substance was applied to six rabbits for 72 hours (SIDS (2002)). On the other hand, as for humans, as a result of a 48-hour application of 0.05 mL of a 33% solution of this substance in acetone to 50 volunteers, it was reported to be not irritating (SIDS (2002)).
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available.
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	It was classified in Category 1 because it was listed as a contact allergen in Contact Dermatitis (5th, 2001) (corresponding to List 1). Besides, there is a human case report on one hairdresser who showed a strong positive response in a patch test, both 48 and 96 hours after using lavender shampoo (SIDS (2002)). This substance is one of the constituents of lavender oil that may cause allergic responses, and this substance is suspected.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, it was reported to be negative in an Ames test and a chromosomal aberration test with human peripheral blood lymphocytes (SIDS (2002)).
6	Carcinogenicity	Classification not possible	- -	-	-	Data are lacking. Besides, it is reported that in a test with female A/He mice given intraperitoneal administration three times a week for eight weeks, no evidence of carcinogenicity was observed at the observation after 24 weeks (SIDS (2002)), but full histopathology was performed on the lung only.
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available. Besides, after ingestion, this substance is hydrolyzed to form linalool in the gastrointestinal tract. In a reproductive test in which oil of coriander containing 72.9% of linalool was orally administered to female rats from day 7 before mating with untreated males during a gestation period until day 4 after parturition (FDA Guideline, GLP), no effects on female fertility were observed, but there is a report on an increase in deaths of fetuses or offspring before or after parturition at the dose that caused toxicity in maternal animals (1000 mg/kg) (SIDS (2002)).
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	In an acute oral toxicity test with rats and mice (LD50 value; rats 14,550 mg/kg, mice 13,360 mg/kg), signs of depression appeared soon after administration, and coma was observed in rats (SIDS (2002)), and 90-minute inhalation exposure to a concentration of 2.74 mg/L caused no death in mice, and a reduction of motility was found (SIDS (2002)). Therefore, it was classified in Category 3 (narcotic effects).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	No data available. Besides, after ingestion, this substance is hydrolyzed to form linalool in the gastrointestinal tract. In a test with rats given 28-day repeated oral administration of oil of coriander containing 72.9% of linalool (160, 400, 1000 mg/kg), hepatocellular vacuolization in all treated females and degenerative lesions in the renal cortex in high-dose males were observed, and it was concluded that the effects of linalool were limited to the liver and kidney (SIDS (2002)).
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 2	- -	H401	P273 P501	It was classified in Category 2 from 48-hour EC50 = 6 mg/L for crustacea (Daphnia magna) (SIDS, 2005).
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. It was classified as "Not classified" due to rapid degradability (a degradation rate by BOD: 75% (SIDS, 2005)), and no bioaccumulation estimate (LogKow = 3.93 (PHYSPROP Database, 2009)) although it was classified in Category 2 in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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