GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 79-92-5
Chemical Name Camphene (mixed optical isomers)
Substance ID 24A6032
Classification year (FY) FY2012
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition)
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition)
7 Flammable solids Classification not possible
-
-
- - There is information that it is combustible (Weiss (2nd, 1986)), but the classification is not possible due to no data. Besides, there is information that it is classified in UN1325 (ICSC (J) (2008)). Division 4.1 (II) corresponds to Category 1, but UN1325 is not adopted because N.O.S. is given to it.
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition)
10 Pyrophoric solids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 265 deg C (ICSC 2008).
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition)
14 Oxidizing solids Not applicable
-
-
- - Organic compounds containing no oxygen, fluorine or chlorine.
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible
-
-
- - It is a solid with a melting point of 55 deg C or lower, but the classification is not possible due to no data.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- - It was classified as "Not classified" based on an LD50 value of > 5,000 mg/kg for rats (USEPA/HPV (2002), corresponding to List 1).
1 Acute toxicity (Dermal) Not classified
-
-
- - It was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification or "Not classified") based on an LD50 value of > 2,500 mg/kg for rabbits (USEPA/HPV (2002)).
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - Data are lacking. Besides, it is described in List 3 information that an LC50 value by 4-hour exposure was 17.1 mg/L (RTECS (2009)), but the details are unknown. Therefore, the classification is not possible.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - No data available.
2 Skin corrosion/irritation Not classified
-
-
- - It was classified as "Not classified" because it was judged as no irritation in a test by a 4-hour application to the rabbit skin (OECD TG404, GLP) (SIDS (Access on June 2012)). Besides, it is reported that it was slightly irritating after a 24-hour occlusive application of undiluted this substance to the rabbit skin (HSDB (2004)), and in humans, it is reported that 4% of this substance in petrolatum produced no irritation after a 48-hour occlusive application (PATTY (5th, 2001)).
3 Serious eye damage/eye irritation Category 2A


Warning
H319 P305+P351+P338
P337+P313
P264
P280
It was classified in Category 2A because it is reported that eye irritation was found in a test with rabbits (OECD TG405: GLP) (SIDS (Access on June 2012)), and it is described that irritation with a risk of serious damage was observed after an application to the rabbit eye (HSDB (2004)).
4 Respiratory sensitization Classification not possible
-
-
- - No data available.
4 Skin sensitization Not classified
-
-
- - No sensitization was observed in a maximization test in 25 human subjects (SIDS (Access on June 2012), PATTY (5th, 2001)), and it is described that this substance was found not to be a sensitizer for human skin (PATTY (5th, 2001)). Therefore, it was classified as "Not classified."
5 Germ cell mutagenicity Not classified
-
-
- - It was classified as "Not classified" based on a negative result in a micronucleus test with bone marrow cells after oral administration to mice (OECD TG474, GLP) (in vivo somatic cell mutagenicity test) (USEPA/HPV (2002)). Besides, as for in vitro tests, it was reported to be negative in an Ames test (SIDS (Access on June 2012)).
6 Carcinogenicity Classification not possible
-
-
- - No data available.
7 Reproductive toxicity Classification not possible
-
-
- - In a test by oral administration to pregnant rats during the organogenesis period (OECD TG414, GLP), symptoms of reduced motor activity and salivation were observed in six out of 20 maternal animals in the high dose group, and resorption rate slightly increased compared to the control group. However, there were no other effects, and no teratogenicity was seen (USEPA/HPV (2002)). Therefore, it was considered that there were no adverse effects on the development of offspring, but data on effects on sexual function and fertility are insufficient, and the details are unknown. Therefore, it was classified as "Classification not possible."
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - In a 28-day repeated oral administration test with rats (OECD TG407, GLP), an increase in saliva flow, vacuolization of hepatocytes, and elevated liver weights were observed in males and females in the high dose group of 1,000 mg/kg/day (converted guidance value: 311 mg/kg/day), and dose-dependent deposit in epithelia of the proximal renal tubules with single-cell necrosis was found in males. Therefore, it is reported that the NOAEL is 250 mg/kg/day (converted guidance value: 77.8 mg/kg/day) for females and < 62.5 mg/kg/day, the low dose (converted guidance value: 19.4 mg/kg/day) for males (USEPA/HPV (2012)). Among the test results, changes in the kidney at down to the low dose were not used for the rationale for classification because it is described that these were nephropathy specific to male rats due to the accumulation of alpha-2-microglobulin, not applicable to humans (USEPA/HPV (2012)). On the other hand, adverse effects on the liver were suggested from the findings at the high dose, but it is unknown whether there are effects around the upper limit of the guidance value range (100 mg/kg/day as converted guidance value) due to insufficient data. Therefore, it was classified as "Classification not possible."
10 Aspiration hazard Classification not possible
-
-
- - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2
-
-
H401 P273
P501
It was classified in Category 2 from 96-hour LC50 = 1.9 mg/L for fish (Cyprinodon variegatus) (SIDS, 2002).
11 Hazardous to the aquatic environment (Long-term) Category 2


-
H411 P273
P391
P501
Reliable chronic toxicity data were not obtained. It was classified in Category 2 because it is not rapidly degradable (a degradation rate by BOD: 2.3% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1988)), and it corresponds to Category 2 in acute toxicity for fish (SIDS, 2002).
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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