GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 107-86-8
Chemical Name 3-Methyl-2-butenal
Substance ID 24A6039
Classification year (FY) FY2012
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 3


Warning
H226 P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
It corresponds to Category 3 from a flash point 25 deg C [closed-cup] (GESTIS (Access on June 2012)) >= 23 deg C and <= 60 deg C.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible
-
-
- - There is a chemical group associated with self-reactive properties (acrylic group) in the molecule, but the classification is not possible due to no data.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 145 deg C (ICSC (2009)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
It was classified in Category 4 based on an LD50 value of 690 mg/kg for rats (SIDS (2003)).
1 Acute toxicity (Dermal) Not classified
-
-
- - It was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification) based on an LD50 value of 3,400 mg/kg for rats (SIDS (2003)).
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 3


Danger
H331 P304+P340
P403+P233
P261
P271
P311
P321
P405
P501
It was classified in Category 3 based on an LC50 value for rats (4-hour exposure) of 3.7 mg/L (1,076 ppmV) (SIDS (2003)). Besides, because the test concentration (0.97-6.08 mg/L) was lower than 90% of the saturated vapour pressure concentration (37.8 mg/L), a reference value of gas was applied.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - No data available.
2 Skin corrosion/irritation Category 1C


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
In a test by an occlusive application of undiluted this substance to the rabbit skin for 3 minutes, 1 hour, or 4 hours, edema, erythema, and necrosis were observed from 1 hour after the application, necrosis that occurred hardened with time and became leather-like, and this persisted until day 8, the end of the observation period. As a result, it was judged as corrosive (SIDS (2003)), therefore it was classified in Category 1C. Besides, it is reported that necrosis in addition to erythema and edema were also found in another test by a 20-hour occlusive application of undiluted this substance to the rabbit skin, and it was assessed to be corrosive (SIDS (2003)).
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
In a test in which 0.05 mL of this substance of 80% purity was applied to the rabbit eye without dilution, severe irritation, staphyloma, and persistent corneal opacity occurred, the symptoms persisted on day 8, the end of the observation period, and it was judged as highly irritating (SIDS (2003)). Therefore, it was classified in Category 1.
4 Respiratory sensitization Classification not possible
-
-
- - No data available.
4 Skin sensitization Category 1B


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501
In a maximization test with guinea pigs (Directive 84/449/EEC, B.6, GLP), 0.2% of this substance was administered intracutaneously at induction, and positive reactions were observed in 3/9 animals (30%) (SIDS (2003)). Therefore, it was classified in Category 1B.
5 Germ cell mutagenicity Not classified
-
-
- - It was classified as "Not classified" from a negative result in a micronucleus test with bone marrow cells after oral administration to mice (in vivo somatic cell mutagenicity test) [OECD TG474, GLP] (SIDS (2003)). Besides, there is a report that it was negative in an unscheduled DNA synthesis test with hepatocytes after oral administration to rats (OECD TG486, GLP) (in vivo somatic cell genotoxicity test) (SIDS (2003)), and as for in vitro tests, it is reported that it was negative or positive in Ames tests (SIDS (2003)) and positive in a chromosomal aberration test with CHL/IU cells (Evaluation of effect for the food safety (Food Safety Commission, 2011)).
6 Carcinogenicity Classification not possible
-
-
- - No data available.
7 Reproductive toxicity Classification not possible
-
-
- - In a developmental toxicity test by oral administration to rats on gestational days 6-19 (OECD TG 414, US EPA OPPTS 870.3700, GLP), pre- and postimplantation loss was not changed at any dose, nor was the proportion of the viable fetuses. And fetal external and histopathological examination did not reveal any increase of malformation or variations compared to the control group, and no developmental toxicity or teratogenicity was observed at any dose (50, 150, 300, 450 mg/kg bw/day) (SIDS (2003)). On the other hand, in a one-generation reproductive test by drinking water administration to rats (OECD TG 415, GLP), parent animals did not show systemic toxicity, water consumption and food consumption decreased, but indices for mating, fertility, and litter size and birth and lactation indices were not changed. Therefore, it is reported that there were no effects on reproductive performance, fertility, or the development of offspring at any dose (6, 21, 77 mg/kg bw/day) (SIDS (2003)). From the above reports, no adverse effects on sexual function/fertility or the development of offspring were observed, but because the one-generation reproductive test has a low highest dose and insufficient assessment of the reproductive process, it was questionable to classify as "Not classified." Therefore, it was classified as "Classification not possible."
8 Specific target organ toxicity - Single exposure Category 1 (respiratory organs)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
In an acute toxicity test by 4-hour inhalation exposure to concentrations of 0.97-6.08 mg/L (vapour) in rats (LC50: 3.7 mg/L), salivation, nasal discharges, closed lids, labored breathing, and unkempt fur were observed in dosed groups, the signs were more pronounced at higher doses and included dyspnea, unsteady gait, apathia, and tremors (SIDS (2003)). Because the test concentrations were within the guidance value range for Category 1, and edematous lung was described as necropsy findings in dead animals in addition to the signs above, it was classified in Category 1 (respiratory system). Besides, in an acute toxicity test by oral administration to rats (doses: 316, 464, 562, 681, 825, 1,000 mg/kg bw, LD50: 690 mg/kg), symptoms of apathy, dyspnea, salivation, labored breathing, tremors, and unsteady gait were found at doses corresponding to the guidance value range for Category 2 (SIDS (2003)).
9 Specific target organ toxicity - Repeated exposure Category 1 (upper respiratory tract)


Danger
H372 P260
P264
P270
P314
P501
In a 28-day inhalation exposure test with rats (OECD TG412, GLP), as symptoms of respiratory tract irritation, focal squamous metaplasia of the respiratory epithelium in the nasal cavity and changes in the larynx cartilage at or above 100 ppm/6 hours (converted guidance value: 0.106 mg/L/6 hours), and atrophy of the olfactory epithelium in part of animals at 300 ppm/6 hours (converted guidance value: 0.318 mg/L/6 hours) were observed (SIDS (2003)). From the results, it was classified in Category 1 (upper respiratory tract) because 100 ppm (converted guidance value: 0.106 mg/L/6 hours) corresponds to the guidance values for Category 1.
10 Aspiration hazard Classification not possible
-
-
- - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3
-
-
H402 P273
P501
It was classified in Category 3 from 96-hour LC50 = 12.7 mg/L for fish (Leuciscus idus) (SIDS, 2005).
11 Hazardous to the aquatic environment (Long-term) Category 3
-
-
H412 P273
P501
Reliable chronic toxicity data were not obtained. It was classified in Category 3 because appropriate data on rapid degradability were not obtained, and it corresponds to Category 3 in acute toxicity for fish (SIDS, 2005).
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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