GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 556-82-1
Chemical Name 3-Methyl-2-buten-1-ol
Substance ID 24A6041
Classification year (FY) FY2012
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 3


Warning
H226 P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
It corresponds to Category 3 from a flash point of 43 deg C [closed-cup] (MSDS (Sigma-Aldrich) (Access on June 2012)) >= 23 deg C and <= 60 deg C.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Type G
-
-
- - There is a chemical group associated with self-reactive properties (unsaturated bond) in the molecule. It is reported in SIDS (2003) that the substance was evaluated to be not explosive from its chemical structure, and the expert rated the reliability as valid. Therefore, it was classified as Type G.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 305 deg C (ICSC (2010)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
Both two LD50 values for rats (1,591 mg/kg and 810 mg/kg) (SIDS (2003)) correspond to Category 4.
1 Acute toxicity (Dermal) Not classified
-
-
- - It was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification) based on an LD50 value of > 4,000 mg/kg for rats and an LD50 value of 3,900 mg/kg for rabbits (SIDS (2003)).
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - From an LC50 value by 4-hour exposure of > 16.8 mg/L for rats (SIDS (2003)), it corresponds to Category 4 or "Not classified," but the category cannot be determined. Therefore, it was classified as "Classification not possible." Besides, due to the description of exposure to the saturated vapour of an extremely high concentration, a reference value for vapour (mg/L) was applied.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - No data available.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
It was classified in Category 1 because the primary dermal irritation index (PDII) was 6.13, and it was judged as corrosive in a test by a 4-hour occlusive application of 0.5 mL of undiluted this substance to the rabbit skin (SIDS (2003)). Besides, it is reported that it was also judged as corrosive in another test by a 20-hour or 24-hour occlusive application of undiluted this substance to the rabbit skin (SIDS (2003)).
3 Serious eye damage/eye irritation Category 2A


Warning
H319 P305+P351+P338
P337+P313
P264
P280
In a test in which 0.1 mL of undiluted this substance was applied to the rabbit eye (Federal Register 38, No. 187), the overall irritation score (equivalent to AOI) was 28.7 (maximum value 110), slight to moderate corneal opacity and moderate conjunctival redness and chemosis were observed and were not completely reversible within an 8-day observation period, and it was judged as highly irritating (SIDS (2003)). Therefore, it was classified in Category 2A.
4 Respiratory sensitization Classification not possible
-
-
- - No data available.
4 Skin sensitization Classification not possible
-
-
- - In humans, it is reported that it was not sensitizing in a maximization test in 26 volunteers (SIDS (2003)), but the details are unknown. Therefore, it was classified as "Classification not possible."
5 Germ cell mutagenicity Not classified
-
-
- - It was classified as "Not classified" based on a negative result in a micronucleus test with bone marrow cells after intraperitoneal administration to mice (in vivo somatic cell mutagenicity test) (OECD TG474, GLP-compliant) (SIDS (2003)). Besides, there is a report on the results of a micronucleus test with bone marrow cells after oral administration to mice, and a high incidence of micronucleated polychromatic erythrocytes was observed only at the highest dose, but it was within the range of historical data, and the potential to induce micronuclei of this substance was considered to be of small biological significance (Evaluation of effect for the food safety (Food Safety Commission, 2010)). And as for in vitro test results, it is reported that it was negative (SIDS (2003)) or weakly positive (Evaluation of effect for the food safety (Food Safety Commission, 2010)) in Ames tests, and weekly positive in a chromosomal aberration test with CHL/IU cells (Evaluation of effect for the food safety (Food Safety Commission, 2010)).
6 Carcinogenicity Classification not possible
-
-
- - No data available.
7 Reproductive toxicity Classification not possible
-
-
- - In a developmental toxicity test by oral administration to rats on gestational days 6-19 (OECD TG 414; GLP), general toxicity (such as general symptoms, decreased food consumption, and reduced weight gain) was observed in maternal animals at the high dose (600 mg/kg), but there were no effects on reproduction parameters such as conception rate, the numbers of corpus lutea, implantations, resorptions, and live fetuses, or the development of offspring, nor were findings to suggest teratogenicity (SIDS (2003)). However, data are insufficient on effects on sexual function and fertility by the administration from before mating, it was classified as "Classification not possible."
8 Specific target organ toxicity - Single exposure Category 2 (systemic toxicity)


Warning
H371 P308+P311
P260
P264
P270
P405
P501
As symptoms observed after oral administration to rats, there is a description of staggering, dyspnea, and restlessness at or above 172 mg/kg, apathy, abdominal position, and reddened eyes and ears at or above 1,376 mg/kg, and lateral or dorsal position and secretions from the eyes and mouth at or above 1,720 mg/kg. And a dose-response was found, with symptoms getting worse with increasing dose, and recovery occurred within seven days at or below 1,376 mg/kg (SIDS (2003)). From the above, the test doses corresponded to guidance values for Category 2, but it was hard to specify the target organ. Therefore, it was classified in Category 2 (systemic toxicity).
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - It is reported that in a 90-day oral administration test by drinking water administration to rats (OECD TG 408; GLP), the only treatment-related findings were a reduction in food and water consumption at the high dose of 5,000 ppm (243.8 (males)-307.2 (females) mg/kg bw/day), which was accompanied by a decrease in body weight and body weight gain, but there were no significant treatment-related changes in other examinations (SIDS (2003)). Because the effects of administration were a reduction in food and water consumption and a decrease in body weight and body weight gain observed at doses above the guidance value range, it corresponds to "Not classified" in the oral route. However, because effects in the other routes (inhalation, dermal) are unknown due to no data, it was classified as "Classification not possible" for specific target organ toxicity (repeated exposure).
10 Aspiration hazard Classification not possible
-
-
- - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3
-
-
H402 P273
P501
It was classified in Category 3 from 96-hour LC50 = 46 mg/L for fish (Leuciscus idus) (SIDS, 2005).
11 Hazardous to the aquatic environment (Long-term) Not classified
-
-
- - If chronic toxicity data are used, then it is classified as "Not classified" due to rapid degradability (readily biodegradable: 82% (SIDS, 2005)), and 21-day NOEC = 3.4 mg/L for crustacea (Daphnia magna) (SIDS, 2005).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to rapid degradability (readily biodegradable: 82% (SIDS, 2005)), a low bioaccumulation estimate (LogKow = 1.17 (PHYSPROP Database (2009))), although it corresponds to Category 3 in acute toxicity for fish (SIDS, 2005).
From the above results, it was classified as "Not classified."
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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