NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	2581-34-2
Chemical Name	4-Nitro-m-cresol
Substance ID	24A6043
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified	- -	-	-	There is a chemical group associated with explosive properties (nitro group) in the molecule. However, in UNRTDG, UN2446 is for this substance, which is classified in Division 6.1, PG III, therefore it does not correspond to the hazards of the highest precedence, explosives.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	- -	-	-	No data available.
8	Self-reactive substances and mixtures	Type G	- -	-	-	There is a chemical group associated with explosive properties (nitro group) in the molecule, and it is classified in Division 6.1, PG III (UN2446) in UNRTDG, therefore it was classified as Type G.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 455 deg C (Ullmanns (E) (6th, 2003)).
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Classification not possible	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (N). However, the classification is not possible due to no data on oxidization.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	There is a report on LD50 values for rats of 2,300 mg/kg for males and 1,200 mg/kg for females (SIDS (1994)), corresponding to "Not classified" in the Classification JIS and Category 4, respectively. It was classified in Category 4 by adopting the category for females, which was more hazardous.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Not classified	- -	-	-	In a test in which 0.5 g/animal of the substance was applied to the skin of three rabbits for 4 hours, it was not irritating at observation after 72 hours (SIDS (1994)). Therefore, it was classified as "Not classified."
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	In a test in which 0.1 g/animal of the substance was applied to the eye of three rabbits, the irritation score after 48 hours was 54.3 in an unwashed group, and it was judged as highly corrosive (SIDS (1994)). Therefore, it was classified in Category 1.
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	It was classified in Category 2 based on a positive result in a micronucleus test with mice (in vivo mutagenicity test) (SIDS (1994)). Besides, as for in vitro tests, there is a report on a negative result in an Ames test and a positive result in a chromosomal aberration test with CHL/IU cells of Chinese hamsters (JECDB (Access on June 2012)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Classification not possible	- -	-	-	In a reproduction/developmental toxicity screening test with rats by repeated oral administration to males before and during mating and females before mating, through mating and gestation, until day 3 of lactation (OECD test guideline, GLP-compliant), parent animals showed general toxicity at the high dose (300 mg/kg), but no treatment-related effects were observed in fertility examination, observation of delivery and maternal behavior, viability and observation of performance status of offspring, etc. (JECDB (Access on June 2012)). And in a developmental toxicity test by oral administration of 25 mg/kg to mice on gestational days 7, 9, and 11, no effects on litter size, postimplantation loss, and incidence of malformations were found (SIDS (1994)). From the above results, no adverse effects on sexual function/fertility of parent animals or the development of offspring for the substance were seen, but it was questionable to use the developmental toxicity test with mice as the rationale to classify as "Not classified" because the test used only one dose that was very low (25 mg/kg: 1/92-1/48 of an LD50 value), and the dosing period was as short as three days during the gestation period (gestational days 7, 9, and 11). Therefore, it was classified as "Classification not possible" due to lack of data.
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data available.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a reproduction/developmental toxicity screening test with rats by repeated oral administration to males before and during mating and females before mating, through mating and gestation, until day 3 of lactation (OECD test guideline, GLP-compliant), one male died in the 300 mg/kg dose group (converted guidance value: about 150 mg/kg/day), its histopathological examination revealed thrombus in the kidney, heart, and lung, and decreased spontaneous activity, prone position, and bradypnea were observed in the male before death and two females (JECDB (Access on June 2012)). From the above results, the NOEL was reported to be 100 mg/kg/day (converted guidance value: about 50 mg/kg/day), but the effects at the upper limit of the guidance value range (converted guidance value: 100 mg/kg/day) are unknown. Therefore, it was classified as "Classification not possible."
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 2	- -	H401	P273 P501	It was classified in Category 2 from 72-hour EC50 = 8.6 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2005).
11	Hazardous to the aquatic environment (Long-term)	Category 2	-	H411	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (not readily degradable, a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1981)), and 21-day NOEC = 0.78 mg/L for crustacea (Daphnia magna) (SIDS, 2005). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 because it is not rapidly degradable (not readily degradable, a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1981)), and it corresponds to Category 2 in acute toxicity for fish (SIDS, 2005). From the above results, it was classified in Category 2.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

To GHS Information