Item | Information |
---|---|
CAS RN | 102-36-3 |
Chemical Name | 3,4-Dichlorophenyl isocyanate |
Substance ID | 24A6083 |
Classification year (FY) | FY2012 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 650 deg C (Hommel (1996)). |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable |
- |
- | - | The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen. |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | It is a solid with a melting point of 55 deg C or lower, but the classification is not possible due to no data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 |
P301+P310
P264 P270 P321 P330 P405 P501 |
It was classified in Category 3 based on an LD50 value of 91 mg/kg for rats (RTECS (2006), the original article: National Technical Information Service, OTS0528439). |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | It was classified as "Not classified" from an LD50 value of > 5,000 mg/kg for rats (IUCLID (2000)), and an LD50 value of > 2,000 mg/kg for rabbits and no dead animals (IUCLID (2000)). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Category 1 |
Danger |
H330 |
P304+P340
P403+P233 P260 P271 P284 P310 P320 P405 P501 |
It was classified in Category 1 based on LC50 values by 4-hour exposure for rats of > 0.452 mg/L (> 58.8 ppm) for males and 0.338 mg/L (44 ppm) for females (IUCLID (2000)). Besides, because the test concentrations were lower than 90% of the saturated vapour pressure concentration (99 ppm), a reference value of gas was applied as a vapour with little mist. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 4 |
Warning |
H332 |
P304+P340
P261 P271 P312 |
It was classified in Category 4 based on an LC50 value of 2.7 mg/L for rats (IUCLID (2000)). Besides, because the test concentration was higher than the saturated vapour pressure concentration (0.77 mg/L), a reference value of dust/mist was applied. |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | It was classified as "Not classified" because it was not irritating in a test by a 4-hour application to the rabbit skin (OECD TG404, GLP-compliant) (IUCLID (2000)), and it was not a primary irritant in another test with rabbits (Federal Hazardous Substance Act, Section 191.11) (IUCLID (2000)). |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
In an eye irritation test with rabbits (OECD TG 405, GLP-compliant), it was assessed as irritating, and a warning was issued on the risk of causing serious eye disorders (IUCLID (2000)). And it is reported that corrosivity and extreme irritation were observed 24 hours after the application in another test with rabbits (Federal Hazardous Substance Act, Section 191.12) (IUCLID (2000)). From the above test results, it was classified in Category 1. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
4 | Skin sensitization | Classification not possible |
- |
- | - | It is reported that it was sensitizing in a maximization test with guinea pigs (OECD TG406, GLP-compliant) (IUCLID (2000)), but the details such as a positive rate are unknown. Therefore, it was classified as "Classification not possible." |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to no in vivo test data. Besides, as for in vitro mutagenicity tests, it is reported that it was negative in both an Ames test (OECD TG 471, 472) and a chromosomal aberration test with V79 cells (OECD TG 473) (IUCLID (2000)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
It was classified in Category 3 (respiratory tract irritation) because it is described that this substance is a strong irritant, especially to the eye and mucous membranes, and it is strongly irritating to the mucosa of the nose and throat (HSDB (2002)). Besides, it is reported that decreased locomotor activity, salivation, and diarrhea were observed after oral administration of 50-100 mg/kg to cats, but there were no effects on hematological profile (IUCLID (2000)). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | It is reported that no deaths or symptoms of poisoning were observed in a test by 14-day oral administration of 100 mg/kg/day (converted guidance value = 15.6 mg/kg/day) to male rats (IUCLID (2000)), but it had only one test dose within the guidance value range, and the test details are unknown. Therefore, it was classified as "Classification not possible." |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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