GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 112-90-3
Chemical Name (Z)-9-Octadecen-1-amine; oleylamine
Substance ID 24A6091
Classification year (FY) FY2012
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Not classified
-
-
- - A flash point is 154 deg C [closed-cup] (MSDS (Sigma-Aldrich) (2012)) above 93 deg C.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible
-
-
- - There is a chemical group associated with self-reactive properties (olefins) present in the molecule, but the classification is not possible due to no data.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 265 deg C (EU-RAR (2008) draft).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Organic compounds containing no oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
It was classified in Category 4 based on an LD50 value for rats of 1,689 mg/kg [OECD TG 401, GLP] (EU-RAR (2008)).
1 Acute toxicity (Dermal) Classification not possible
-
-
- - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - No data available.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
It was classified in Category 1 because it is reported that necrosis was noted, and average Draize scores were 4.0 for both erythema and edema in a test by a 4-hour semi-occlusive application of 0.5 mL of the test substance to the rabbit skin (OECD TG 404), which was terminated for humane reasons (EU-RAR (2008)), and in another test with rabbits and almost the same test conditions (OECD TG 404), average Draize scores after 24, 48, and 72 hours for erythema and edema were 4.0, 3.7, and 3.7, and corrosive effects (eschar, scabbing, scarring) were observed at the application sites of all animals (EU-RAR (2008)).
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
There are no available data on eye test results, but because it was classified as being corrosive to the skin (Category 1), it was classified in Category 1.
4 Respiratory sensitization Classification not possible
-
-
- - No data available.
4 Skin sensitization Classification not possible
-
-
- - No data available.
5 Germ cell mutagenicity Not classified
-
-
- - It was classified as "Not classified" based on a negative result in a chromosomal aberration test with bone marrow cells after oral administration to mice (in vivo somatic cell mutagenicity test) (EU-RAR (2008)). Besides, as for in vitro tests, it is reported that it was negative in all of an Ames test, a mouse lymphoma test (OECD TG 476), a chromosomal aberration test with CHO cells, and an HPRT test with CHO cells (EU-RAR (2008)).
6 Carcinogenicity Classification not possible
-
-
- - No data available.
7 Reproductive toxicity Classification not possible
-
-
- - In developmental toxicity tests by oral administration to pregnant rats and rabbits during the organogenesis period, no embryotoxicity or teratogenicity was observed in either animal species even at the doses where maternal animals showed toxic signs and reduced weight gain, and this substance did not affect the development of offspring (EU-RAR (2008)). However, because effects on sexual function and fertility are unknown due to no data, it was classified as "Classification not possible."
8 Specific target organ toxicity - Single exposure Category 2 (systemic toxicity)


Warning
H371 P308+P311
P260
P264
P270
P405
P501
In an acute oral toxicity test with rats (200, 500, 1,000, 2,000 mg/kg bw), clinical signs of hypokinesia, sedation, dyspnea, and abdominal swelling were observed, but no abnormalities were found at necropsy, and an LD50 value of 1,689 mg/kg was reported (EU-RAR (2008)). The specific doses where the signs occurred are unknown, and the target organ could not be determined from the signs, however, because the LD50 value was within the guidance value range for Category 2, it was classified in Category 2 (systemic toxicity).
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - In a 28-day repeated oral administration test with rats (OECD TG 407), biochemical test findings of an increase in total bilirubin, a slight increase in urea nitrogen, and slight increases in the activities of ASAT and ALAT, liver enzymes, were observed in addition to reduced weight gain, impairment of motility, and changes in blood tests such as an increase in hematocrit value at 50 mg/kg/day (converted guidance value: 15.5 mg/kg/day), but no histopathological findings of toxicological significance related to these changes were obtained (EU-RAR (2008)). And because there are no data around the upper limit of the guidance value range, higher than the above dose, it was classified as "Classification not possible" due to lack of data. Besides, in a 14-day repeated dermal administration test with rats, repeated administration of higher doses was difficult because it is a corrosive substance, and no systemic effects were found at the dose tested (converted guidance value, 3.5 mg/kg/day) (EU-RAR (2008)).
10 Aspiration hazard Classification not possible
-
-
- - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501
It was classified in Category 1 from 96-hour LC50 = 0.11 mg/L for fish (Pimephales promelas) (EU-RAR, 2008).
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (not readily degradable, a degradation rate by BOD: -3, -5, -5% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2008)), and 21-day NOEC = 0.013 mg/L for crustacea (Daphnia magna) (EU-RAR, 2008).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable (not readily degradable, a degradation rate by BOD: -3, -5, -5% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2008)), and 96-hour LC50 = 0.11 mg/L for fish (Pimephales promelas) (EU-RAR, 2008).
From the above results, it was classified in Category 1.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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