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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	122-40-7
Chemical Name	Amylcinnamaldehyde
Substance ID	24A6097
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (normal temperatures) (At 1013 mbar/20 deg C: liquid (GESTIS (Access on Aug. 2012)))
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (normal temperatures) (At 1013 mbar/20 deg C: liquid (GESTIS (Access on Aug. 2012)))
5	Gases under pressure	Not applicable	- -	-	-	Liquid (normal temperatures) (At 1013 mbar/20 deg C: liquid (GESTIS (Access on Aug. 2012)))
6	Flammable liquids	Not classified	- -	-	-	A flash point is 113 deg C [closed-cup] (MSDS (Sigma-Aldrich 2012)) above 93 deg C.
7	Flammable solids	Not applicable	- -	-	-	Liquid (normal temperatures) (At 1013 mbar/20 deg C: liquid (GESTIS (Access on Aug. 2012)))
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There are no chemical groups associated with explosive properties, but a chemical group associated with self-reactive properties (acryloyl group) present in the molecule, however, there are no data.
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (normal temperatures) (At 1013 mbar/20 deg C: liquid (GESTIS (Access on Aug. 2012)))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (normal temperatures) (At 1013 mbar/20 deg C: liquid (GESTIS (Access on Aug. 2012)))
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification) based on an LD50 value of 3,730 mg/kg for rats (USEPA/HPV (2005), corresponding to List 1).
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" because it is reported that there were no deaths after administration of 2,000 mg/kg bw to rabbits, and an LD50 value was > 2,000 mg/kg (USEPA/HPV (2005)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (normal temperatures) (At 1013 mbar/20 deg C: liquid (GESTIS (Access on Aug. 2012)))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It was classified in Category 2 because it is described that it is a severe skin irritant in humans (HSDB (2012)), and there is a report on List 3 knowledge that it was severely irritating in a Draize test in which 100 mg was applied to the rabbit skin for 24 hours (RTECS (2011)).
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available.
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	It was classified in Category 1 because it is listed as a contact allergen in Contact Dermatitis (Frosch) (5th, 2011) (corresponding to List 1). Besides, this substance was given Sh as a sensitizer in DFG classification in Germany (MAK/BAT (2011)). And as for humans, allergic reactions often occurred after the use of a cream containing this substance and alpha-amylcinnamic alcohol, and chronic recalcitrant eczema was observed in markedly sensitive cases among people who reacted to this substance (HSDB (2012)).
5	Germ cell mutagenicity	Not classified	- -	-	-	It was classified as "Not classified" because it is reported that it was negative in an in vivo micronucleus test with mouse bone marrow (in vivo somatic cell mutagenicity test) (USEPA/HPV (2005)). Besides, as for in vitro tests, there is a report on a negative result in an Ames test (USEPA/HPV (2005)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Because there were no deaths or evidence of toxicity after dermal administration of 2,000 mg/kg bw to rabbits (USEPA/HPV (2005)), it corresponds to "Not classified" in the dermal route. And only depression and porphyrin-like deposits around the eye and nose are described as findings in an oral administration test with rats, and an LD50 value was reported to be 3,730 mg/kg (USEPA/HPV (2005)), but the details are unknown. Furthermore, because of no data in inhalation administration, it was classified as "Classification not possible" for specific target organ toxicity (single exposure).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a 14-week diet administration toxicity test with rats, liver and kidney weights increased in the high dose group at 4,000 ppm (males 287.3 mg/kg, females 320.3 mg/kg), but these were not associated with related histopathological changes, and no differences from the control group were seen in food consumption, hematological measurements, serum analyses, urine tests, and other test items (USEPA/HPV (2005)). From the results, the high dose of 4,000 ppm where effects were found exceeded the guidance value range, therefore it corresponds to "Not classified" in the oral route. However, because effects in the other routes (inhalation, dermal) are unknown due to no data, it was classified as "Classification not possible" for specific target organ toxicity (repeated exposure).
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 48-hour EC50 = 0.28 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)).
11	Hazardous to the aquatic environment (Long-term)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (readily biodegradable, BOD 51% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1981)), and 21-day NOEC = 0.014 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable (readily biodegradable, BOD: 51% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1981)), and 96-hour LC50 = 0.91 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)). From the above results, it was classified in Category 1.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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