NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	583-78-8
Chemical Name	2,5-Dichlorophenol
Substance ID	24A6110
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	- -	-	-	No data available. Besides, there is the information: a flash point of 100 deg C [closed-cup] (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on Sep. 2012) (the original article: Acros reagent catalog)).
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification) based on an LD50 value of 2,475 mg/kg for rats (USEPA/HPV (2008), corresponding to List 1).
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" based on an LD50 value of > 8,000 mg/kg for rabbits (USEPA/HPV (2008)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	It was classified as "Not classified" based on an LC50 value of > 185 mg/L/4 hours for rats (USEPA/HPV (2008)). Besides, because the test concentration was higher than the saturated vapour pressure concentration (0.49 mg/L), a reference value of dust/mist was applied.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	No data available. Besides, in a 21-day repeated dermal administration test with rabbits at 1.0, 10, 100 mg/kg (6 hours/day), skin lesions at the application site consisting of thickening, encrustation, necrosis, leatherness, and foci in the dermis and epidermis were reported in all treated animals (USEPA/HPV (2008)).
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available.
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Not classified	- -	-	-	It was classified as "Not classified" based on a negative result in a micronucleus test with bone marrow cells after oral administration to mice (in vivo somatic cell mutagenicity test) (USEPA/HPV (2008)). Besides, as for in vitro tests, it is reported that it was negative in an Ames test (NTP DB (1979)) and negative in an HGPRT test with CHO cells (OECD TG476) (USEPA/HPV (2008)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system), Category 3 (respiratory tract irritation)	Warning	H371 H335	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	In an acute oral toxicity test with rats (doses: 1,600, 2,500, 4,000 mg/kg), deaths occurred at all doses, and excessive breathing, equilibrium disturbance, tremor, and tonic-clonic spasms in the ventral region were observed in dead animals (USEPA/HPV (2008)), and in an acute oral toxicity test with mice (LD50: 1,600 mg/kg (males), 946 mg/kg (females)), increased respiration, tremors, slight convulsions followed by central nervous system depression were found as the primary toxic signs (HSDB (2009)). From the above reports, test doses corresponded to the guidance value range for Category 2, therefore it was classified in Category 2 (central nervous system). And it was classified in Category 3 (respiratory tract irritation) because clear nasal discharge, slight dyspnea, etc. were seen as a result of inhalation exposure to 50 mg/L in rats, and all the animals recovered after 24 hours (USEPA/HPV (2008)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver, respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	In a 28-day repeated inhalation exposure test with rats (vapour: 0.1, 0.3, 1.0 mg/L, 5 days/week, 6 hours/day), ASAT in the liver function tests increased in males and females in the 1.0 mg/L group (converted guidance value: 0.3 mg/L), absolute liver weights decreased in males at or above 0.3 mg/L, and on histopathological examination, the incidence of foci and necrosis in the liver in the treated groups was slightly higher than in the control group. LOAEL was reported to be 0.1 mg/L (converted guidance value: 0.03 mg/L) based on the liver effects above (USEPA/HPV (2008)), and the dose (LOAEL) corresponded to the guidance values for Category 1. Therefore, it was classified in Category 1 (liver). And it is also described that inflammatory cell and lymphocyte infiltrate, macrophage aggregation, and alveolar septal fibrosis in the lung of all treated animals, and inflammation in the nasal cavity (mucosa) in the 1.0 mg/L group (converted guidance value: 0.3 mg/L) were observed in the test (USEPA/HPV (2008)), therefore it was classified in Category 1 (respiratory system). Besides, in a 21-day repeated dermal administration test with rabbits (doses: 1, 10, 100 mg/kg bw/day, 5 days/week, 6 hours/day), no systemic toxicity related to the administration of this substance was found, and NOAEL was reported to be 100 mg/kg bw/day (USEPA/HPV (2008)).
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 2	- -	H401	P273 P501	It was classified in Category 2 from 96-hour LC50 = 3.29 mg/L for fish (Platichthys flesus) (AQUIRE, 2013).
11	Hazardous to the aquatic environment (Long-term)	Category 2	-	H411	P273 P391 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 2 because it is not rapidly degradable (a degradation rate by BOD: 5% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1982)), and it was classified in Category 2 in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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