Item | Information |
---|---|
CAS RN | 634-66-2 |
Chemical Name | 1,2,3,4-Tetrachlorobenzene |
Substance ID | 24A6117 |
Classification year (FY) | FY2012 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable |
- |
- | - | The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon. |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | It is a solid with a melting point of 55 deg C or lower, but the classification is not possible due to no data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
There are reports on two LD50 values for rats of 1,167 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 8 (Ministry of the Environment, 2010)) and 1,470 mg/kg (EHC 128 (1991)), both of which correspond to Category 4. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | No data available. |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | No data available. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, there is a report on a negative result in an Ames test (NTP DB (1980)), a negative result in a chromosomal aberration test with CHO cells (NTP DB (Access on Sep. 2012)), and a positive result in a sister chromatid exchange test with CHO cells. |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. |
7 | Reproductive toxicity | Category 1B |
Danger |
H360 |
P308+P313
P201 P202 P280 P405 P501 |
As a result of gavage administration to females rats on gestational days 6-15 (doses: 50, 100, 200 mg/kg/day), there were no effects on body weights, organ weights, and blood in maternal animals, but a decrease in the number of live fetuses was observed at the high dose (Environmental Risk Assessment for Chemical Substances vol. 8 (Ministry of the Environment, 2010)), and because effects were found in fetuses at the dose that did not cause general toxicity in parent animals, it was classified in Category 1B. Besides, it is reported that in another test by gavage administration to females rats on gestational days 9-13 (doses: 100, 300, 1,000 mg/kg/day), yolk sac diameter, fetal crown-rump length and head length significantly decreased at the middle dose where slight to moderate hepatocellular hypertrophy was seen in maternal animals (Environmental Risk Assessment for Chemical Substances vol. 8 (Ministry of the Environment, 2010)). |
8 | Specific target organ toxicity - Single exposure | Category 2 (systemic toxicity), Category 3 (narcotic effects) |
Warning |
H371
H336 |
P308+P311
P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
In an acute oral toxicity test with rats, there were clinical signs of depression, flaccid muscle tone, prostration, piloerection, loose stool, hypothermia, and coma and necropsy findings of distention and hemorrhage in the gastrointestinal tract, and an LD50 value was 1,167 mg/kg (EHC 128 (1991)). From the above, it was hard to specify the target organ, but because the LD50 value was within the guidance value range for Category 2, it was classified in Category 2 (systemic toxicity). And it was classified in Category 3 (narcotic effects) because depression and coma were observed. |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (liver) |
Warning |
H373 |
P260
P314 P501 |
In diet administration tests with rats, tissue degeneration in the liver was observed in the 500 ppm group (converted guidance value: 18 mg/kg/day) after 28-day administration (0.5, 5, 50, 500 ppm, converted guidance value: 0.018, 0.18, 1.8, 18 mg/kg/day), and the incidence of mild liver degeneration increased at 500 ppm (25 mg/kg/day) after 90-day administration (0.5, 5, 50, 500 ppm, 0.025, 0.25, 2.5, 25 mg/kg/day) (Environmental Risk Assessment for Chemical Substances vol. 8 (Ministry of the Environment, 2010)). Based on the above reports, it was classified in Category 2 (liver) because both the doses corresponded to the guidance values for Category 2. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 |
Warning |
H400 |
P273
P391 P501 |
It was classified in Category 1 from 48-hour EC50 = 0.13 mg/L for crustacea (Ceriodaphnia dubia) (CICAD 60, 2004). |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 |
P273
P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (not readily degradable, a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1982)), and 32-day NOEC = 0.0245 mg/L for fish (Pimephales promelas) (AQUIRE, 2013). Acute toxicity data were not obtained for a trophic level for which chronic toxicity data are not obtained. From the above results, it was classified in Category 1. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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