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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	644-97-3
Chemical Name	Phenyldichlorophosphine
Substance ID	24A6118
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	- -	-	-	A flash point of 113 deg C [closed-cup] (MSDS (Sigma-Aldrich) (2012)) is above 93 deg C.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 159.4 deg C (319 deg F) (HSDB (2003)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	There is the information that it reacts vigorously with water and produces heat to emit toxic and corrosive hydrogen chloride or the vapour of hydrochloric acid (Hommel (1996)). However, because it does not emit flammable gases, it was classified as "Not classified."
13	Oxidizing liquids	Classification not possible	- -	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded to the element other than carbon or hydrogen (S). However, it was classified as "Classification not possible" due to no data.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	The classification is not possible due to no data in prescribed test methods. Besides, it is described that it corrodes metals, except 316 stainless steel, nickel, or Hastelloy (HSDB 2003), and "This substance is corrosive to most metals. Stainless steel (316), nickel, Hastelloy, glass, ceramic, and synthetic substances are resistant" (Hommel (1996)).

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	In an acute toxicity test with rats (OECD TG 420, GLP), there were no deaths after the administration of 500 mg/kg (0/10), an LD50 value was > 500 mg/kg, and one animal died (1/1) after the administration of 2,000 mg/kg in a preliminary dose-finding test previously conducted (USEPA/HPV (2004), corresponding to List 1). Therefore, it was classified in Category 4. Besides, this substance reacts vigorously with water and hydrolyzes. As for health hazards, also refer to hydrogen chloride (CAS: 7647-01-0) and phenylphosphine (CAS: 638-21-1), the degradation products.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	It was classified in Category 1 because it is described that it is a high irritant to the skin, eye, and mucous membranes and is highly capable of causing deaths or permanent injury due to exposure of normal use in humans (HSDB (2003)), and it is also described that it is corrosive to the skin and tissue (HSDB (2003)).
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	It was classified in Category 1 because it is described that it is a high irritant to the skin, eye, and mucous membranes and is highly capable of causing deaths or permanent injury due to exposure of normal use in humans (HSDB (2003)), and it is also described that it is corrosive to the skin and tissue (HSDB (2003)).
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, there is a report on a positive result in an Ames test (USEPA/HPV (2004)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	It was classified in Category 3 (respiratory tract irritation) because it is described that breathing this substance can irritate the nose and throat and cause cough and shortness of breath, and high exposure can cause pneumonia and pulmonary edema (HSFS (2000)). Besides, it is reported that in an acute oral toxicity test with rats (OECD TG 420, GLP), no deaths or apparent toxic signs were observed after the administration of 500 mg/kg, and necropsy revealed mottled lung and froth in the trachea in two animals. And it is reported that in a preliminary test, one animal that died after the administration of 2,000 mg/kg showed black gastrointestinal contents, and gastrointestinal bleeding was suggested (USEPA/HPV (2004)). However, these were regarded as local effects because this substance is corrosive.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	No data available.
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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