GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 1461-25-2
Chemical Name Tetrabutyltin
Substance ID 24A6125
Classification year (FY) FY2012
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Not classified
-
-
- - A flash point of 107 deg C [closed-cup] (SDS (Sigma-Aldrich) (Access on Sep. 2012)) is above 93 deg C.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible
-
-
- - No data available.
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- - It contains a metalloid (Sn), but it is estimated that it does not react vigorously with water from water solubility data of 6.4E-005 mg/L (25 deg C) (SRC Phys Prop (Access on Sep. 2012)).
13 Oxidizing liquids Not applicable
-
-
- - Organic compounds containing no oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- - It was classified as "Not classified" because there were no deaths in a test by the administration of 2,000 mg/kg to rats (OECD TG423, GLP), and an LD50 value was >= 2,000 mg/kg (SIDS (2007)).
1 Acute toxicity (Dermal) Not classified
-
-
- - It was classified as "Not classified" in the Classification JIS (Category 5 in UN GHS classification or "Not classified") based on an LDLo of 2,100 mg/kg for rabbits (IUCLID (2000)).
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - No data available.
2 Skin corrosion/irritation Classification not possible
-
-
- - No data available.
3 Serious eye damage/eye irritation Category 2B
-
Warning
H320 P305+P351+P338
P337+P313
P264
It was classified in Category 2B because it is reported that it was slightly irritating in a test in which 500 mg was applied to the rabbit eye (IUCLID (2000)).
4 Respiratory sensitization Classification not possible
-
-
- - No data available.
4 Skin sensitization Classification not possible
-
-
- - No data available.
5 Germ cell mutagenicity Not classified
-
-
- - It was classified as "Not classified" based on a negative result in a micronucleus test with bone marrow cells after oral administration to mice (in vivo somatic cell mutagenicity test) (SIDS (2007)). Besides, as for in vitro tests, it was reported to be negative in an Ames test (SIDS (2007)).
6 Carcinogenicity Classification not possible
-
-
- - It was classified as "Classification not possible" because ACGIH classified organic tin compounds in A4 (ACGIH (2001)).
7 Reproductive toxicity Category 2


Warning
H361 P308+P313
P201
P202
P280
P405
P501
In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by diet administration to rats (OECD TG422, GLP), no adverse effects on sexual function/fertility were observed, but as for the development of offspring, a decreased number of pups delivered per litter, decreased numbers of live pups per litter on postnatal days 1 and 4, increased pup mortality on postnatal day 4, and an increased number of runts were found compared to the control group at the highest dose of 2,000 ppm where general toxicity such as decreased body weights occurred in parent animals (SIDS (2007)). Furthermore, in a developmental toxicity test by oral administration to rats on gestation days 13-15, an increased incidence of malformations such as cleft palate was seen in offspring at or above 229 mg/kg/day where maternal animals showed reduced weight gain, and the increase was significant only at the highest dose of 1,833 mg/kg/day (SIDS (2007)). Therefore, it was classified in Category 2.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects)


Warning
H336 P304+P340
P403+P233
P261
P271
P312
P405
P501
There were no deaths in an acute oral toxicity test with rats (OECD TG423, GLP) (doses: 300, 2,000 mg/kg bw), and signs of hunched posture, lethargy, ataxia, and piloerection were observed at 2,000 mg/kg (SIDS (2007)). However, because the animals recovered after 1-2 days, it was classified in Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Category 2 (spleen, thymus, lymph node)


Warning
H373 P260
P314
P501
In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats (OECD TG422, GLP), after diet administration to males for 33 days and females from 2 weeks before mating through mating, gestation, and parturition, until postnatal days 4-5 (0, 100, 300, 2,000 ppm), spleen and thymus weights decreased at 2,000 ppm (100-130 mg/kg/day: converted guidance value about 37-62 mg/kg/day) corresponding to the guidance values Category 2, and slight to severe lymphoid depletion in the thymus in females and localized sinusoidal blood in the mesenteric lymph nodes in males were observed (SIDS (2007)). Therefore, it was classified in Category 2 (spleen, thymus, lymph node).
10 Aspiration hazard Classification not possible
-
-
- - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501
It was classified in Category 1 from 24-hour LC50 = 0.002 mg/L for crustacea (Daphnia magna) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
Reliable chronic toxicity data were not obtained. It was classified in Category 1 because it is not rapidly degradable (not readily degradable, a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1991)), and it was classified in Category 1 in acute toxicity.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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