Item | Information |
---|---|
CAS RN | 4461-52-3 |
Chemical Name | 1-Methoxymethanol |
Substance ID | 24A6133 |
Classification year (FY) | FY2012 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 3 |
Warning |
H226 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
For a commercially available product, a mixture containing 45% methanol, there is data: a flash point of 39.9 deg C (ChemNet (on the web)). Because it was >= 23 deg C and <= 60 deg C, it was classified in Category 3. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
It was classified in Category 4 based on LD50 values for rats of 1,269 mg/kg (males) and 1,451 mg/kg (females) (JECDB (Access on Oct. 2012)). Because the commercially available product of this substance (CAS: 4461-52-3) contains methanol and formaldehyde, also refer to methanol (CAS: 67-56-1) and formaldehyde (CAS: 50-00-0) for health hazards. Besides, the classification in this hazard class was based on the results of a test on a substance of 46.73% purity containing 44.93% methanol. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | No data available. |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | No data available. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, it is reported that it was positive in both an Ames test and a chromosomal aberration test with CHL cells (JECDB (Access on Oct. 2012)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with male and female rats by oral administration from 14 days before mating and through mating, for total 44 days for males, and through gestation and parturition by the lactation day 3 for females (OECD TG 422), in the high dose group (300 mg/kg/day), death, reduced weight gain, and decreased food consumption in males were observed in addition to disturbances in the gastrointestinal tract such as erosion and ulcers in the stomach. No effects of the test substance were found on copulation index, fertility index, gestation length, gestation index, delivery index, and parturition and lactation behavior in parent animals, and on examination of neonates, no effects of this substance were observed on the number of pups born, the number of live pups, sex ratio, live birth index, neonatal survival, general status, and body weights. Furthermore, a visceral examination on neonates on day 4 revealed only a slight increase in the incidence of patent foramen ovale, toxicological significance of which is unknown, in the 300 mg/kg group, and no anomalies considered due to this substance were found on external and skeletal examination (JECDB (Access on Oct. 2012)). Therefore, there were no effects on sexual function/fertility in parent animals. However, due to insufficient data on effects on the development of offspring including teratogenicity, it was classified as "Classification not possible." |
8 | Specific target organ toxicity - Single exposure | Category 2 (systemic toxicity) |
Warning |
H371 |
P308+P311
P260 P264 P270 P405 P501 |
In a single-dose toxicity test by oral administration to rats (doses: 707, 1,414, 2,000, 2,828 mg/kg), decreased locomotor activity, bradypnea, ptosis, salivation, lying on side, gasping, clonic convulsion, lacrimation, reddish tear, reddish nasal discharge, and straub tail were observed on the day of administration, and deaths were seen in the groups at or above 1,000 mg/kg. Necropsy revealed atrial dilatation, congestion/edema in the lung, congestion/edema/hemorrhage/erosion in the stomach, flatulence in the gastrointestinal tract in dead animals, and thickening/erosion/ulcers in the stomach and adhesion of stomach and liver in surviving animals in the groups at or above 1,414 mg/kg (JECDB (Access on Oct. 2012)). The above findings were within the guidance value range for Category 2, but because it was hard to specify the target organ, it was classified in Category 2 (systemic toxicity). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration to rats (OECD TG 422), disturbances in the gastrointestinal tract such as erosion and ulcers in the stomach and thickening in the duodenum were observed in males and females in the 300 mg/kg group (converted guidance value: about 150 mg/kg/day) above the guidance value range. Other major changes at the dose were death in males, anemic changes such as decreases in erythrocyte counts, hematocrit values, and hemoglobin levels, and increased reticulocyte counts in blood tests, and decreases in total protein, albumin, and calcium, and an increase in A/G ratio in clinical biochemistry tests. In the 60 mg/kg group below that (converted guidance value: about 30 mg/kg/day), effects of the test substance were limited to histopathological changes in the stomach in males, and they might be caused by irritation of formaldehyde that was formed by degradation of this substance in the stomach (JECDB (Access on Oct. 2012)). Therefore, the lesions in the stomach were not used for the rationale for classification. And due to no data in the other routes, it was classified as "Classification not possible" for this hazard class. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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