GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 4461-52-3
Chemical Name 1-Methoxymethanol
Substance ID 24A6133
Classification year (FY) FY2012
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 3


Warning
H226 P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
For a commercially available product, a mixture containing 45% methanol, there is data: a flash point of 39.9 deg C (ChemNet (on the web)). Because it was >= 23 deg C and <= 60 deg C, it was classified in Category 3.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible
-
-
- - No data available.
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
It was classified in Category 4 based on LD50 values for rats of 1,269 mg/kg (males) and 1,451 mg/kg (females) (JECDB (Access on Oct. 2012)).

Because the commercially available product of this substance (CAS: 4461-52-3) contains methanol and formaldehyde, also refer to methanol (CAS: 67-56-1) and formaldehyde (CAS: 50-00-0) for health hazards.
Besides, the classification in this hazard class was based on the results of a test on a substance of 46.73% purity containing 44.93% methanol.
1 Acute toxicity (Dermal) Classification not possible
-
-
- - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - No data available.
2 Skin corrosion/irritation Classification not possible
-
-
- - No data available.
3 Serious eye damage/eye irritation Classification not possible
-
-
- - No data available.
4 Respiratory sensitization Classification not possible
-
-
- - No data available.
4 Skin sensitization Classification not possible
-
-
- - No data available.
5 Germ cell mutagenicity Classification not possible
-
-
- - The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, it is reported that it was positive in both an Ames test and a chromosomal aberration test with CHL cells (JECDB (Access on Oct. 2012)).
6 Carcinogenicity Classification not possible
-
-
- - No data available.
7 Reproductive toxicity Classification not possible
-
-
- - In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with male and female rats by oral administration from 14 days before mating and through mating, for total 44 days for males, and through gestation and parturition by the lactation day 3 for females (OECD TG 422), in the high dose group (300 mg/kg/day), death, reduced weight gain, and decreased food consumption in males were observed in addition to disturbances in the gastrointestinal tract such as erosion and ulcers in the stomach. No effects of the test substance were found on copulation index, fertility index, gestation length, gestation index, delivery index, and parturition and lactation behavior in parent animals, and on examination of neonates, no effects of this substance were observed on the number of pups born, the number of live pups, sex ratio, live birth index, neonatal survival, general status, and body weights. Furthermore, a visceral examination on neonates on day 4 revealed only a slight increase in the incidence of patent foramen ovale, toxicological significance of which is unknown, in the 300 mg/kg group, and no anomalies considered due to this substance were found on external and skeletal examination (JECDB (Access on Oct. 2012)). Therefore, there were no effects on sexual function/fertility in parent animals. However, due to insufficient data on effects on the development of offspring including teratogenicity, it was classified as "Classification not possible."
8 Specific target organ toxicity - Single exposure Category 2 (systemic toxicity)


Warning
H371 P308+P311
P260
P264
P270
P405
P501
In a single-dose toxicity test by oral administration to rats (doses: 707, 1,414, 2,000, 2,828 mg/kg), decreased locomotor activity, bradypnea, ptosis, salivation, lying on side, gasping, clonic convulsion, lacrimation, reddish tear, reddish nasal discharge, and straub tail were observed on the day of administration, and deaths were seen in the groups at or above 1,000 mg/kg. Necropsy revealed atrial dilatation, congestion/edema in the lung, congestion/edema/hemorrhage/erosion in the stomach, flatulence in the gastrointestinal tract in dead animals, and thickening/erosion/ulcers in the stomach and adhesion of stomach and liver in surviving animals in the groups at or above 1,414 mg/kg (JECDB (Access on Oct. 2012)). The above findings were within the guidance value range for Category 2, but because it was hard to specify the target organ, it was classified in Category 2 (systemic toxicity).
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration to rats (OECD TG 422), disturbances in the gastrointestinal tract such as erosion and ulcers in the stomach and thickening in the duodenum were observed in males and females in the 300 mg/kg group (converted guidance value: about 150 mg/kg/day) above the guidance value range. Other major changes at the dose were death in males, anemic changes such as decreases in erythrocyte counts, hematocrit values, and hemoglobin levels, and increased reticulocyte counts in blood tests, and decreases in total protein, albumin, and calcium, and an increase in A/G ratio in clinical biochemistry tests. In the 60 mg/kg group below that (converted guidance value: about 30 mg/kg/day), effects of the test substance were limited to histopathological changes in the stomach in males, and they might be caused by irritation of formaldehyde that was formed by degradation of this substance in the stomach (JECDB (Access on Oct. 2012)). Therefore, the lesions in the stomach were not used for the rationale for classification. And due to no data in the other routes, it was classified as "Classification not possible" for this hazard class.
10 Aspiration hazard Classification not possible
-
-
- - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- - No data available.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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