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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	7173-51-5
Chemical Name	Didecyldimethylammonium chloride
Substance ID	24A6134
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	- -	-	-	No data available.
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	The substance is an organic compound containing chlorine which is a chlorine ion ionically bonded to quaternary ammonium and does not contribute to oxidization.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	It was classified in Category 3 based on LD50 values of 238 mg/kg and 262 mg/kg for rats (EPA RED (2006)).
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification) based on an LD50 value of 2,930 mg/kg for rabbits (EPA RED (2006)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	It was classified in Category 2 based on an LC50 value of 0.07 mg/L by 4-hour exposure in rats (HPVIS (2009), corresponding to List 2). Besides, because the LC50 value was higher than the saturated vapour pressure concentration (4.54E-10 mg/L), it was regarded as an inhalation test on dust.
2	Skin corrosion/irritation	Category 1C	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	In a test by a 4-hour application to the skin of one rabbit, severe irritation symptoms continued for 24 hours, becoming leathery, decoloration, and necrosis were observed in the skin, and the test was ended because corrosivity was found on observation at 24 hours after the application. As a result, this substance was assessed to be corrosive to the rabbit skin (HPVIS (2009)). Therefore, it was classified in Category 1C. Besides, it was classified in C; R34 in EU classification (EC-JRC (ESIS) (Access on Oct. 2012)).
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Extreme corneal opacity, iritis, and conjunctival irritation occurred, and the eye looked out of shape 1 hour after an application to the eye of one rabbit, and the total irritation score was 94 (maximum 110). The test was ended after 1 hour due to evidence of corrosivity obtained, and this substance was assessed to be corrosive to the rabbit eye (HPVIS (2009)). Therefore, it was classified in Category 1.
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	It was classified in Category 1 because it is listed as a contact allergen in Contact Dermatitis (5th, 2011) (corresponding to List 1). Besides, it is reported that the positive rate was 0% (0/20) in a skin sensitization test with guinea pigs (a Buehler test), and this substance was not a sensitizer (HPVIS (2009)).
5	Germ cell mutagenicity	Not classified	- -	-	-	It was classified as "Not classified" based on a negative result in a chromosomal aberration test with bone marrow cells after oral administration to rats (in vivo somatic cell mutagenicity test) (USEPA/HPV (2005)). Besides, as for in vitro tests, it is reported that it was negative in all of an Ames test (HPVIS (2009)), a chromosomal aberration test with CHO cells (USEPA/HPV (2005)), and an HGPRT test with CHO cells (USEPA/HPV (2005)).
6	Carcinogenicity	Not classified	- -	-	-	In a 104-week diet administration test with male and female rats (USEPA/HPV (2005)) and a 78-week diet administration test with male and female mice (HPVIS (2009)), reduced weight gain was observed as treatment-related effects in the high dose groups (rats: 1,500 ppm, mice: 1,000 ppm) in both tests, but no oncogenicity was found. Because there was no evidence of carcinogenicity in long-term administration tests with two animal species, it was classified as "Not classified."
7	Reproductive toxicity	Classification not possible	- -	-	-	In a developmental toxicity test by oral administration to pregnant rats during the organogenesis period, maternal animals showed general toxicity such as decreases in body weights and food consumption, audible respiration, and gasping at the dose above 37.5 mg/kg/day, and a significant increase in late resorptions was observed at the dose of 50 mg/kg/day, but the effect was regarded to be due to maternal toxicity (HSDB (2010)). And in a developmental toxicity test by oral administration to pregnant rabbits during the organogenesis period, maternal animals showed general toxicity such as audible respiration, decreased weight gain, and hypoactivity at the dose of 3 mg/kg/day or above, and an increased number of dead fetuses/litter was found at 10 mg/kg/day where deaths were seen (USEPA/HPV (2005)). Adverse developmental effects were observed in both the tests, but because there were also deaths of maternal animals, they were estimated to be caused by severe maternal toxicity. Therefore, it was classified as "Classification not possible" due to lack of data. Besides, it is reported that in a two-generation reproductive test by diet administration to rats, reduced weight gain and decreased food consumption were found in the high dose group (1,000 ppm), but no reproductive toxicity was seen (USEPA/HPV (2005)).
8	Specific target organ toxicity - Single exposure	Category 2 (systemic toxicity)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In an acute oral toxicity test with rats (doses: 100-400 mg/kg, LD50 value, 262 mg/kg), there were signs such as inanimation, lacrimation, and diarrhea, and necropsy revealed discoloration and hemorrhage in the stomach and red-brown contents in the intestine in dead animals, but no marked changes in surviving animals (HPVIS (2009)). And in another acute oral toxicity test with rats (doses: 100-500 mg/kg, LD50 value, 238 mg/kg), primary signs were reported to include discoloration of urine, feces, and saliva, strabismus, ataxia, body tremors, labored respiration, slight to severe depression, and abdominal spasm (HPVIS (2009)). The above findings occurred at doses corresponding to the guidance value range for Category 1, but because it was hard to specify the target organ, and they were List 2 information, it was classified in Category 2 (systemic toxicity).
9	Specific target organ toxicity - Repeated exposure	Category 2 (systemic toxicity)	Warning	H373	P260 P314 P501	Almost no findings of adverse effects were seen at doses within the guidance value range in tests by 13-week or 104-week diet administration to rats, or 13-week or 78-week diet administration to mice, but blood-filled sinuses, hemosiderosis, and histiocytosis in the mesentery lymph node were observed at 1,500 ppm (75 mg/kg/day) corresponding to the guidance values for Category 2 only in a 104-week administration test with rats (USEPA/HPV (2005)). And it is reported that in an 8-week oral administration test with dogs, at 60 mg/kg/day (converted guidance value: 37 mg/kg/day), decreases in weight gain and food consumption as well as signs such as increased emesis, salivation, soft feces, and thin appearance were found, and mortality increased (HSDB (2010)). Because it was hard to specify the target organ for the above findings, it was classified in Category 2 (systemic toxicity).
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 24-hour LC50 = 0.018 mg/L for crustacea (Daphnia magna) (AQUIRE, 2013).
11	Hazardous to the aquatic environment (Long-term)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (not readily degradable, a degradation rate by BOD: -3, -2, -2% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2008)), and 72-hour NOEC = 0.025 mg/L for algae (Pseudokirchneriella subcapitata) (AQUIRE, 2013). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable (not readily degradable, a degradation rate by BOD: -3, -2, -2% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2008)), and 96-hour LC50 = 0.39 mg/L for fish (Oncorhynchus kisutch) (AQUIRE, 2013). From the above results, it was classified in Category 1.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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