Item | Information |
---|---|
CAS RN | 7756-94-7 |
Chemical Name | Triisobutylene |
Substance ID | 24A6135 |
Classification year (FY) | FY2012 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 3 |
Warning |
H226 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
It corresponds to Category 3 because a flash point of 42 deg C [closed-cup] (Hommel (1996)) is >= 23 deg C and <= 60 deg C. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is a chemical group associated with self-reactive properties (unsaturated bond) present in the molecule, but because it is classified in Class 3 (III) in UNRTDG (UN2324), it does not apply to hazards of the highest precedence, self-reactive substances and mixture. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 355 deg C (Hommel (1996)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | It was classified as "Not classified" because it is reported that there were no deaths in a test by the administration of 2,000 mg/kg to rats (OECD TG401, GLP), and an LD50 value was >= 2,000 mg/kg (JECDB (Access on Oct. 2012)). |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | No data available. |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | No data available. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, it is reported that it was negative in both an Ames test, and a chromosomal aberration test with Chinese hamster CHL cells (JECDB (Access on Oct. 2012)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | In an acute oral toxicity test with rats (OECD TG401, GLP), after the administration of 2,000 mg/kg, only decreased spontaneous activity and diarrhea were observed, there were no deaths or macroscopic abnormalities on necropsy, and a smooth course of body weights was shown (JECDB (Access on Oct. 2012)). Therefore, it corresponds to "Not classified" in the oral route. However, because effects are unknown in the other routes due to no data, it was classified as "Classification not possible" due to lack of data. |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | In a 28-day repeated oral administration test with rats (Guidelines specified by the Chemical Substances Control Law, GLP) (doses: 30, 150, 750 mg/kg/day), in the groups at or above 150 mg/kg/day (converted guidance value: 46.7 mg/kg/day), there were increases in liver weights in males and females and kidney weights in males, necropsy showed swelling and paleness of the kidney, and histological examination revealed swelling of liver cells in both sexes and eosinophilic bodies in the kidney in males of all groups. Therefore, the liver and kidney were estimated to be the target organs. However, the incidences and severity of these lesions decreased in the recovery group, and it is described that they were considered to be reversible (JECDB (Access on Oct. 2012)). From the above, the above findings occurred within the guidance values for Category 2, but liver effects were slight, and the findings in the kidney were possibly alpha-2-micro globulin nephropathy specific to male rats (SIAP (2012)). Because the other treatment-related effects are unknown, the classification is not possible due to lack of data. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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